ID   NDH2_SCHPO              Reviewed;         551 AA.
AC   O43090;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   07-JUL-2009, entry version 51.
DE   RecName: Full=Probable NADH-ubiquinone oxidoreductase C947.15c, mitochondrial;
DE            EC=1.6.5.3;
DE   Flags: Precursor;
GN   ORFNames=SPBC947.15c;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the
RT   fission yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Catalyzes the oxidation of NADH (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the NADH dehydrogenase family.
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DR   EMBL; CU329671; CAA17043.1; -; Genomic_DNA.
DR   PIR; T40767; T40767.
DR   RefSeq; NP_595261.1; -.
DR   GeneID; 2540211; -.
DR   KEGG; spo:SPBC947.15c; -.
DR   NMPDR; fig|4896.1.peg.1127; -.
DR   GeneDB_Spombe; SPBC947.15c; -.
DR   OMA; O43090; DYLIMAY.
DR   ArrayExpress; O43090; -.
DR   GO; GO:0005739; C:mitochondrion; IDA:GeneDB_SPombe.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013027; FAD_pyr_nucl-diS_OxRdtase.
DR   InterPro; IPR001327; Pyr_OxRdtase_NAD_bd.
DR   Pfam; PF00070; Pyr_redox; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00368; FADPNR.
PE   2: Evidence at transcript level;
KW   Complete proteome; FAD; Flavoprotein; Mitochondrion; NAD;
KW   Oxidoreductase; Transit peptide; Ubiquinone.
FT   TRANSIT       1     35       Mitochondrion (Potential).
FT   CHAIN        36    551       Probable NADH-ubiquinone oxidoreductase
FT                                C947.15c, mitochondrial.
FT                                /FTId=PRO_0000337258.
FT   NP_BIND      92    122       FAD (By similarity).
FT   NP_BIND     255    291       NAD (By similarity).
SQ   SEQUENCE   551 AA;  60781 MW;  C8CE3C56F88108AC CRC64;
     MSVSKARLQS VVRLSRTVPY SKTMVRSFHV SCAVKNSGNV PTPRNKSFFS RALEMAEVTS
     SLSMLGAVAL FQSLRRLNNS SPKGKSGVPK KNIVVLGSGW GAVAAIKNLD PSLYNITLVS
     PRDHFLFTPM LPSCTVGTLR LPSITEPIVA LFKGKIDPSN IHQAECTAID TSAKKVTIRG
     TTEANEGKEA VIPYDTLVFA IGAGNQTFGI QGVRDHGCFL KEAGDAKKVF NRIFEILEQV
     RFNKDLSPEE RARLLHITVV GGGPTGMEFA AEMQDFIDND VKDMFPELQK DIHVTLIEAA
     PGVLPMFTKS LITYTENLFK NLNIKIMTKT VVKDVNEKNL IVQKTNPDGS KAMQEIPYGM
     LVWAAGITAR PLTRTLMSSI PEQSGARKGL IVDEFFRVKG VPEMYAVGDC AFSGLPATAQ
     VANQQGAWLA KNLNVEGKKF ALHERIQALE KQLGEKEAPS QVAGLKQQVE QLKLEPFKYH
     HQGALAYVGD EKAIADLKLP FMKKMLPLQG IVGHTFWRLA YLNELISARS QFMVLIDWLK
     TRLFGRYDAK V
//