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Protein

Pre-mRNA-processing factor 17

Gene

prp17

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions in the second step of pre-mRNA splicing. Involved in splicing intron which are longer than 200 nucleotides.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-processing factor 17
Gene namesi
Name:prp17
ORF Names:SPBC6B1.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC6B1.10.
PomBaseiSPBC6B1.10. prp17.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: GO_Central
  • nucleus Source: PomBase
  • Prp19 complex Source: PomBase
  • spliceosomal complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Pre-mRNA-processing factor 17PRO_0000278391Add
BLAST

Proteomic databases

MaxQBiO43071.

Interactioni

Subunit structurei

Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
prp19O140115EBI-538927,EBI-590830

Protein-protein interaction databases

BioGridi277683. 83 interactions.
IntActiO43071. 41 interactions.
MINTiMINT-4675084.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JB9electron microscopy3.60g1-558[»]
ProteinModelPortaliO43071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati264 – 30441WD 1Add
BLAST
Repeati308 – 34942WD 2Add
BLAST
Repeati351 – 39141WD 3Add
BLAST
Repeati394 – 43340WD 4Add
BLAST
Repeati437 – 47640WD 5Add
BLAST
Repeati484 – 52340WD 6Add
BLAST
Repeati526 – 55833WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000214672.
InParanoidiO43071.
KOiK12816.
OMAiDSGEITQ.
OrthoDBiEOG092C2BKC.
PhylomeDBiO43071.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR032847. PRPF17.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR22847:SF474. PTHR22847:SF474. 1 hit.
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVANYSSDS EEQENSQSPN IQPLLHTENL APAVVDNVKD DLIVSKGGNS
60 70 80 90 100
RELARNVPVN EMVQPALGPA NPFVTKEQDS IKNSITGYAE REYVPNFVFN
110 120 130 140 150
QEYYANTHAI YGKRNFDDNE ATTSTDLKRK SQKIKERRED PGDPSILEGD
160 170 180 190 200
GAYKGPWAGY GSEQSSSPLE YSEYEEVESL DVKSEKDTES NNLGQNELLK
210 220 230 240 250
EQLATPEVET HRSKEETILH KDRLFDYQNR SYMHVPNDVG INLSEEPGEQ
260 270 280 290 300
TCYIPKKHIF TWKGHTKGIS CLRFFPISGH LLLSGSMDNQ IKIWEVYHDR
310 320 330 340 350
SLLRTFQGHA RPIRDLSFSQ DGRSFLSTSF DKTIKLWDTE LGKCLNCFNS
360 370 380 390 400
DRLTNCVKFQ VDPDKPNEFL AGTADKRILQ FDIRSPDIVQ AYDHHLGGIN
410 420 430 440 450
SITFLENGKR FVTTSDDSSM RFWEYGTPVP IKFVADIAMH SMPRVALRPN
460 470 480 490 500
GKSIACQSLD NCIYVYSAYE KYRQNKKKVF KGYSCSGYSL EVGFSPDGRF
510 520 530 540 550
VFSGDSSGNA CFWDWKTCKL MAKLPAHSGP VQSMAFHPQE TSKVATSSIV

DGSIKYWD
Length:558
Mass (Da):63,132
Last modified:June 1, 1998 - v1
Checksum:i78859607D4460195
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA17053.1.
PIRiT40651.
RefSeqiNP_596089.1. NM_001022004.2.

Genome annotation databases

EnsemblFungiiSPBC6B1.10.1; SPBC6B1.10.1:pep; SPBC6B1.10.
GeneIDi2541168.
KEGGispo:SPBC6B1.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA17053.1.
PIRiT40651.
RefSeqiNP_596089.1. NM_001022004.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JB9electron microscopy3.60g1-558[»]
ProteinModelPortaliO43071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277683. 83 interactions.
IntActiO43071. 41 interactions.
MINTiMINT-4675084.

Proteomic databases

MaxQBiO43071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC6B1.10.1; SPBC6B1.10.1:pep; SPBC6B1.10.
GeneIDi2541168.
KEGGispo:SPBC6B1.10.

Organism-specific databases

EuPathDBiFungiDB:SPBC6B1.10.
PomBaseiSPBC6B1.10. prp17.

Phylogenomic databases

HOGENOMiHOG000214672.
InParanoidiO43071.
KOiK12816.
OMAiDSGEITQ.
OrthoDBiEOG092C2BKC.
PhylomeDBiO43071.

Miscellaneous databases

PROiO43071.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR032847. PRPF17.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR22847:SF474. PTHR22847:SF474. 1 hit.
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRP17_SCHPO
AccessioniPrimary (citable) accession number: O43071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.