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Protein

Probable helicase mot1

Gene

mot1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its ATPase activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1383 – 1390ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable helicase mot1 (EC:3.6.4.-)
Alternative name(s):
Modifier of transcription 1
TBP-associated factor mot1
Gene namesi
Name:mot1Imported
ORF Names:SPBC1826.01c, SPBC25B2.12.c, SPBC6B1.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1826.01c.
PomBaseiSPBC1826.01c. mot1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743341 – 1953Probable helicase mot1Add BLAST1953

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei144Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43065.
PRIDEiO43065.

PTM databases

iPTMnetiO43065.

Interactioni

Subunit structurei

Forms a complex with TBP which binds TATA DNA.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276189. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliO43065.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 74HEAT 1Sequence analysisAdd BLAST39
Repeati358 – 396HEAT 2Sequence analysisAdd BLAST39
Repeati513 – 551HEAT 3Sequence analysisAdd BLAST39
Repeati554 – 592HEAT 4Sequence analysisAdd BLAST39
Repeati608 – 646HEAT 5Sequence analysisAdd BLAST39
Repeati1191 – 1229HEAT 6Sequence analysisAdd BLAST39
Repeati1270 – 1311HEAT 7Sequence analysisAdd BLAST42
Domaini1370 – 1543Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST174
Repeati1580 – 1623HEAT 8Sequence analysisAdd BLAST44
Domaini1725 – 1877Helicase C-terminalPROSITE-ProRule annotationAdd BLAST153

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1494 – 1497DEGH boxSequence analysis4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Sequence analysis
Contains 8 HEAT repeats.Sequence analysis
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000210415.
InParanoidiO43065.
KOiK15192.
OMAiREEDMVD.
OrthoDBiEOG092C02J3.
PhylomeDBiO43065.

Family and domain databases

Gene3Di1.25.10.10. 6 hits.
3.40.50.300. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR022707. DUF3535.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF12054. DUF3535. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTRLDRLVV LLDSGSTSVV RETAAKQIGD IQKVHPDELY NLLGRVVPYL
60 70 80 90 100
KSKNWDTRVA AAKAIGGIVE NVPVWNPNRT SPVKKEETED LPSFNGDTEE
110 120 130 140 150
KPFIKTEEGA PASSQSQVVV SSNLTSNSEV SKLEEERLST RSHSQEIKPI
160 170 180 190 200
VDFGPDEETA KELNTELKGK FENSLLSFES FDIANVLKAG KKLLGSASRD
210 220 230 240 250
YDVNPANYST HYLQQLSNLK SRLDLAGEYL DDSIMNDLGD NVGSNSKGSP
260 270 280 290 300
TTSIPEHKTS INNNKPEDTP TPSENVHLSA RQRNALKRKA RQMKNSQKVR
310 320 330 340 350
VIDVAPTLVH QQNSTSSADK KTGADYNFTA QSRSDRLVVE HKAPIVPSAA
360 370 380 390 400
VAVTSDSVWP FETLVELLLI DMFDPSWEIR HGACMGLREI IRYAGFGYGR
410 420 430 440 450
VVGKSEAENE QLNKKYFDDL LCRIACVFAL DRFGDYLADQ VVAPIRESVS
460 470 480 490 500
QVLGVALIYV PNDSVFSMYK VLHSLVFQNE LGLTNTVWEA AHGGMLGIKY
510 520 530 540 550
LVAVKYPLFF SHSDYLDSLI NTVIHGLANH DDDVRAVSAL TLLPIADKLV
560 570 580 590 600
QEKLSSCKNL LKVLWDCLDD VKDDLSSSTS CVMDLLSSLC SFTEVMNLMQ
610 620 630 640 650
ETANSDPEFS FETLVPRLFH LMRYTLTGVR RSVVYALTKF ISVQTSCSWI
660 670 680 690 700
TGLTLRLCFQ NVLLEQQEDI SKSSCELAQR VMDILYRDGP ESFSKLLYSH
710 720 730 740 750
IEPMLKVSIT PIGSFRRPYP LDTTLIVKPS GQPYAPSTSR ERNNNISELS
760 770 780 790 800
NSRTKHRAKD DPKGSFCFSV DEPMLNGDVE FVGEERMLKA RLRASSLLGR
810 820 830 840 850
IIGRWKRDEI LLFFKPFLQA CLTSSFSTPV VLGSRLIESF FEVEDNDLTI
860 870 880 890 900
QKDELYHLLC DQFATVPREN YANLVSQLHV VRAQCNALLN TFLDVGRLSR
910 920 930 940 950
SKIPSLAVVV KGDPEAGPIA FGIADAEKLV GPTYENLCKL LSPSQKAQSS
960 970 980 990 1000
KALNEIKYLI IDEISIYKIA KERQDIQCSA SIASAMVTYD KLPKKLNSII
1010 1020 1030 1040 1050
KGIMESIKKE QFSCLQMHSA SAMMKLISAC YKESRQVISE KIVRNLCAYV
1060 1070 1080 1090 1100
CMDTTETPIF HDSGKNGILS LHSIGTSDDN DEQVSGKLVD DSDDVSNDRK
1110 1120 1130 1140 1150
SSLSSVSDKD AAVLQRMGAQ LTLQQMAQNF GSSLFSRVPV LSQCLFVPLQ
1160 1170 1180 1190 1200
QYAESGFPSE VDQASCTVGQ DLLDAMSILR FLVAYLDSGL QSEIVSTLPH
1210 1220 1230 1240 1250
LLATLQSNYS AVRNMASKCF AAITESNAAG SKALHLLVED VVPLLGDASS
1260 1270 1280 1290 1300
TIHRQGAIEC IYHVVQRLGV RILPYILYLI IPLLGRMSDA DQDVRVLATT
1310 1320 1330 1340 1350
SFATLVKLVP LEAGLPDPPD LPQYLLDSRE KERKFLEQML NPSKVEAFSI
1360 1370 1380 1390 1400
PVPISADLRK YQQEGVNWLA FLNKYELHGI LCDDMGLGKT LQTICIVASD
1410 1420 1430 1440 1450
HYNRQKLFEE SGSPKFAHVP SLIVCPSTLA GHWQQELSTY APFLKVSAYV
1460 1470 1480 1490 1500
GPPAERAKIR SKMKKSDVVV TSYDICRNDV DELVKIDWNY CVLDEGHVIK
1510 1520 1530 1540 1550
NARAKLTKAV KSLRSYHRLI LSGTPIQNNV LELWSLFDFL MPGFLGTEKT
1560 1570 1580 1590 1600
FQERFVRPIA ASRDAKSSSK ERERGTLALE AIHKQVLPFM LRRLKEDVLA
1610 1620 1630 1640 1650
DLPPKIIQDY YCDMSDLQRK LLNDFVSQLN INEELEDDET EKTQGTRKKK
1660 1670 1680 1690 1700
SQKAHIFQAL QYMRKLCNHP ALILTEKHPK RNAIVKQLAK ENSGLHDLKH
1710 1720 1730 1740 1750
APKLTALGQL LRDCGLGNSS VNSNGIDSAL TNAVSEHRVL IFCQLKDMLD
1760 1770 1780 1790 1800
MVEKDLLQAT MPDVTYMRLD GSVEPTKRQE AVTKFNNDPS IDVLLLTTHV
1810 1820 1830 1840 1850
GGLGLNLTGA DTVIFVEHDW NPMRDLQAMD RAHRIGQKKV VNVYRLITRG
1860 1870 1880 1890 1900
CLEEKIMGLQ RFKMNVASTV VNQQNAGLSS IGTDQILDLF NTTADEQQTV
1910 1920 1930 1940 1950
QNIDKEESED AAGRGLSGTS KKALEGLPEM WDESQYDEFN LDGFISTLPK

DAS
Length:1,953
Mass (Da):217,632
Last modified:November 8, 2005 - v4
Checksum:i0F53BB674ECC3038
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027981 Genomic DNA. Translation: BAA87285.1.
CU329671 Genomic DNA. Translation: CAA21270.1.
PIRiT39739. T40642.
RefSeqiNP_596080.2. NM_001021992.3.

Genome annotation databases

EnsemblFungiiSPBC1826.01c.1; SPBC1826.01c.1:pep; SPBC1826.01c.
GeneIDi2539633.
KEGGispo:SPBC1826.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027981 Genomic DNA. Translation: BAA87285.1.
CU329671 Genomic DNA. Translation: CAA21270.1.
PIRiT39739. T40642.
RefSeqiNP_596080.2. NM_001021992.3.

3D structure databases

ProteinModelPortaliO43065.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276189. 2 interactors.

PTM databases

iPTMnetiO43065.

Proteomic databases

MaxQBiO43065.
PRIDEiO43065.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1826.01c.1; SPBC1826.01c.1:pep; SPBC1826.01c.
GeneIDi2539633.
KEGGispo:SPBC1826.01c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1826.01c.
PomBaseiSPBC1826.01c. mot1.

Phylogenomic databases

HOGENOMiHOG000210415.
InParanoidiO43065.
KOiK15192.
OMAiREEDMVD.
OrthoDBiEOG092C02J3.
PhylomeDBiO43065.

Miscellaneous databases

PROiO43065.

Family and domain databases

Gene3Di1.25.10.10. 6 hits.
3.40.50.300. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR022707. DUF3535.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF12054. DUF3535. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT1_SCHPO
AccessioniPrimary (citable) accession number: O43065
Secondary accession number(s): O74784, O94734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 30, 2016
This is version 109 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.