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Protein

Probable proteasome subunit beta type-1

Gene

pre3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei25NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit beta type-1 (EC:3.4.25.1)
Gene namesi
Name:pre3
ORF Names:SPBC4C3.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4C3.10c.
PomBaseiSPBC4C3.10c. pre3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000266411 – 24Removed in mature formBy similarityAdd BLAST24
ChainiPRO_000002664225 – 226Probable proteasome subunit beta type-1Add BLAST202

Keywords - PTMi

Zymogen

Proteomic databases

MaxQBiO43063.
PRIDEiO43063.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi277395. 3 interactors.
MINTiMINT-4675013.
STRINGi4896.SPBC4C3.10c.1.

Structurei

3D structure databases

ProteinModelPortaliO43063.
SMRiO43063.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000091079.
InParanoidiO43063.
KOiK02738.
OMAiHDRIYCC.
OrthoDBiEOG092C4SID.
PhylomeDBiO43063.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR035140. Proteasome_beta6.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
PANTHERiPTHR11599:SF82. PTHR11599:SF82. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43063-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTVKDTMN VDINAIKKGE IRMGTTITAL RYKDGVILAA DSRTTMGAYI
60 70 80 90 100
ANRVTDKLTQ LTDNIWCCRS GSAADTQTVA DLLKYYLSMY RIQFGHDPSV
110 120 130 140 150
HTAATLASEM CYQNKNMLSA GLIVAGYDEK TGGDVYSIPL GGSLHKQPLA
160 170 180 190 200
IGGSGSAFIY GFCDANFREN MTQEEAVEFL KNAVALAMER DGSSGGTIRM
210 220
VILNKDGMER KFFAIDTANP IPVFTH
Length:226
Mass (Da):24,564
Last modified:June 1, 1998 - v1
Checksum:i88AEEF4B2A87093A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16832.1.
PIRiT40487.
RefSeqiNP_596295.1. NM_001022216.2.

Genome annotation databases

EnsemblFungiiSPBC4C3.10c.1; SPBC4C3.10c.1:pep; SPBC4C3.10c.
GeneIDi2540878.
KEGGispo:SPBC4C3.10c.

Similar proteinsi

Entry informationi

Entry nameiPSB1_SCHPO
AccessioniPrimary (citable) accession number: O43063
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 1998
Last modified: September 27, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families