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Protein

Probable proteasome subunit beta type-1

Gene

pre3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei25 – 251NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit beta type-1 (EC:3.4.25.1)
Gene namesi
Name:pre3
ORF Names:SPBC4C3.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4C3.10c.
PomBaseiSPBC4C3.10c. pre3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • proteasome core complex, beta-subunit complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 2424Removed in mature formBy similarityPRO_0000026641Add
BLAST
Chaini25 – 226202Probable proteasome subunit beta type-1PRO_0000026642Add
BLAST

Keywords - PTMi

Zymogen

Proteomic databases

MaxQBiO43063.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi277395. 3 interactions.
MINTiMINT-4675013.

Structurei

3D structure databases

ProteinModelPortaliO43063.
SMRiO43063. Positions 16-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000091079.
InParanoidiO43063.
KOiK02738.
OMAiTSIMAVQ.
OrthoDBiEOG092C4SID.
PhylomeDBiO43063.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43063-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTVKDTMN VDINAIKKGE IRMGTTITAL RYKDGVILAA DSRTTMGAYI
60 70 80 90 100
ANRVTDKLTQ LTDNIWCCRS GSAADTQTVA DLLKYYLSMY RIQFGHDPSV
110 120 130 140 150
HTAATLASEM CYQNKNMLSA GLIVAGYDEK TGGDVYSIPL GGSLHKQPLA
160 170 180 190 200
IGGSGSAFIY GFCDANFREN MTQEEAVEFL KNAVALAMER DGSSGGTIRM
210 220
VILNKDGMER KFFAIDTANP IPVFTH
Length:226
Mass (Da):24,564
Last modified:June 1, 1998 - v1
Checksum:i88AEEF4B2A87093A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16832.1.
PIRiT40487.
RefSeqiNP_596295.1. NM_001022216.2.

Genome annotation databases

EnsemblFungiiSPBC4C3.10c.1; SPBC4C3.10c.1:pep; SPBC4C3.10c.
GeneIDi2540878.
KEGGispo:SPBC4C3.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16832.1.
PIRiT40487.
RefSeqiNP_596295.1. NM_001022216.2.

3D structure databases

ProteinModelPortaliO43063.
SMRiO43063. Positions 16-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277395. 3 interactions.
MINTiMINT-4675013.

Protein family/group databases

MEROPSiT01.010.

Proteomic databases

MaxQBiO43063.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC4C3.10c.1; SPBC4C3.10c.1:pep; SPBC4C3.10c.
GeneIDi2540878.
KEGGispo:SPBC4C3.10c.

Organism-specific databases

EuPathDBiFungiDB:SPBC4C3.10c.
PomBaseiSPBC4C3.10c. pre3.

Phylogenomic databases

HOGENOMiHOG000091079.
InParanoidiO43063.
KOiK02738.
OMAiTSIMAVQ.
OrthoDBiEOG092C4SID.
PhylomeDBiO43063.

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiO43063.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSB1_SCHPO
AccessioniPrimary (citable) accession number: O43063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.