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Protein

Eukaryotic translation initiation factor 3 subunit F

Gene

eif3f

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translational initiation Source: PomBase
  • formation of cytoplasmic translation initiation complex Source: PomBase

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SPO-72649. Translation initiation complex formation.
R-SPO-72689. Formation of a pool of free 40S subunits.
R-SPO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SPO-72702. Ribosomal scanning and start codon recognition.

Protein family/group databases

MEROPSiM67.975.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit F1 PublicationUniRule annotation
Short name:
eIF3f1 PublicationUniRule annotation
Gene namesi
Name:eif3f1 Publication
ORF Names:SPBC4C3.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4C3.07.
PomBaseiSPBC4C3.07.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003473271 – 302Eukaryotic translation initiation factor 3 subunit FAdd BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineUniRule annotation1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43060.
PRIDEiO43060.

PTM databases

iPTMnetiO43060.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex appears to include tif32/eif3a, SPAC25G10.08/eif3b, tif33/eif3c, SPBC4C3.07/eif3f, tif35/eif3g and sum1/eif3i. This set of common subunits may also associate exclusively with either moe1/eif3d and int6/eif3e, or with SPAC821.05/eif3h and SPAC1751.03/eif3m. The eIF-3 complex may also include SPAC3A12.13c/eif3j.UniRule annotation1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277385. 2 interactors.
MINTiMINT-4674986.
STRINGi4896.SPBC4C3.07.1.

Structurei

3D structure databases

ProteinModelPortaliO43060.
SMRiO43060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 165MPNPROSITE-ProRule annotationAdd BLAST143

Sequence similaritiesi

Belongs to the eIF-3 subunit F family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000241154.
InParanoidiO43060.
KOiK03249.
OMAiAVDMEYH.
OrthoDBiEOG092C3KDS.
PhylomeDBiO43060.

Family and domain databases

CDDicd08064. MPN_eIF3f. 1 hit.
HAMAPiMF_03005. eIF3f. 1 hit.
InterProiView protein in InterPro
IPR027531. eIF3f.
IPR000555. JAMM/MPN+_dom.
IPR024969. Rpn11/EIF3F_C.
PANTHERiPTHR10540:SF14. PTHR10540:SF14. 1 hit.
PfamiView protein in Pfam
PF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
SMARTiView protein in SMART
SM00232. JAB_MPN. 1 hit.
PROSITEiView protein in PROSITE
PS50249. MPN. 1 hit.

Sequencei

Sequence statusi: Complete.

O43060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGTKHVLH LTKPSSRSSP LNIVIEPAVL FSILDHSTRK SENNQRVIGT
60 70 80 90 100
LLGTRSEDGR EIEIKSCFAV PHNESSEQVE VEMEYHRAMY HLHLKANPRE
110 120 130 140 150
VVVGWYATSP DLDAFSALIQ NLYASPAEPG TAPLGTYPHP CVHLTVNTDV
160 170 180 190 200
SSPLAIKTYV SSPVGITERL ADSCAFVPTP FTIRDDEAVR SGLKAVAAPK
210 220 230 240 250
NDPSRLASLF TDLQQLRRST LELLSMIERV SDYVQNVIDG SSPANVAVGR
260 270 280 290 300
YLMKCFSLIP CVEGQDFEKI FSSHLQDVLV VVYLANTLRT QVDIASRLNL

LP
Length:302
Mass (Da):33,251
Last modified:June 1, 1998 - v1
Checksum:iA046E087CF083D84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16829.1.
PIRiT40490.
RefSeqiNP_596298.1. NM_001022219.2.

Genome annotation databases

EnsemblFungiiSPBC4C3.07.1; SPBC4C3.07.1:pep; SPBC4C3.07.
GeneIDi2540868.
KEGGispo:SPBC4C3.07.

Similar proteinsi

Entry informationi

Entry nameiEIF3F_SCHPO
AccessioniPrimary (citable) accession number: O43060
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 1, 1998
Last modified: September 27, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families