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Protein

Forkhead protein sep1

Gene

sep1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for promoter sequence element PCB-driven, M-phase-specific transcription. Acts as a transcriptional activator with a role in the regulation of mitosis. Regulates septation and the periodic transcription of cdc15.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi128 – 22295Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Septation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead protein sep1
Gene namesi
Name:sep1
ORF Names:SPBC4C3.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4C3.12.
PomBaseiSPBC4C3.12. sep1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • M/G1 phase-specific MADS box-forkhead transcription factor complex Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
  • transcription factor complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 663663Forkhead protein sep1PRO_0000091907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei446 – 4461Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43058.

PTM databases

iPTMnetiO43058.

Interactioni

Protein-protein interaction databases

BioGridi277383. 112 interactions.

Structurei

3D structure databases

ProteinModelPortaliO43058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO43058.
OrthoDBiEOG7647BS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFNSTNPYY FTHEKNLNNA SKYSELPIAY QEIPLQSLPP YPKVASKLKG
60 70 80 90 100
VVAGGKENNI ASFQKPSSKA TRPYIPSYTR LTYSVPPLPI PPPSEQSLDT
110 120 130 140 150
IIYRNPSVSS SQSQEPEEFF LPLDDGKKPP YSYAMLIGMS IIRSPDRRLT
160 170 180 190 200
LSAIYDWISN TFSFYNKSNN GWQNSIRHNL SLNKAFMKIE RPRNLPGKGH
210 220 230 240 250
FWSIRPGHEE QFLKLKLRKP GVNSRPAPPV QDVTSSTKYG SSTGSSGFNT
260 270 280 290 300
FNTSPHIFNQ RHQYLQNYYT ASLTNIPTIS NVNATNFHPL HSQQPYVDTP
310 320 330 340 350
GIDAPSDLEA KFSDLGVSSV VSVTSPLQSC TNSPSPPLSS PASSASPSES
360 370 380 390 400
LRNESLGIKS AKSLGLNKDD APVEGPPVSH LEKDVETPSV HDSVLGFNDT
410 420 430 440 450
VTNLGKKGLK DGTTNTLQIP AVRLPSLPSS PTIKNPSGLL LKRSNSIDFP
460 470 480 490 500
TPPKALCPKL FCFRDDIVAD DYTKFSLLSP IRSDMSGISA SPNTNLKEHR
510 520 530 540 550
TRILQMLATP DAKQLSSLTS SDAEFWSVTP LKSSILRNGD ASKQVTLSES
560 570 580 590 600
PKGDSLLDGG SLSYFTNNIS SVAGLETPSK LPMSKSFDTF EDDFLDPMDM
610 620 630 640 650
LSFENHFSDF NSNRKVSPVK REVRRKYISS ATTIHSSAAQ DDTYLPSPTK
660
RKMPLLRQTS TLF
Length:663
Mass (Da):73,032
Last modified:June 1, 1998 - v1
Checksum:iA66099437B7714C2
GO

Sequence cautioni

The sequence AAC49903.1 differs from that shown. Reason: Frameshift at positions 86, 123 and 583. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti377 – 38711PVSHLEKDVET → TCITFGEGCCN in AAC49903 (PubMed:9427538).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88191 Genomic DNA. Translation: AAC49903.1. Frameshift.
CU329671 Genomic DNA. Translation: CAA16826.1.
PIRiJC6500.
T40493.
RefSeqiNP_596301.1. NM_001022222.2.

Genome annotation databases

EnsemblFungiiSPBC4C3.12.1; SPBC4C3.12.1:pep; SPBC4C3.12.
GeneIDi2540866.
KEGGispo:SPBC4C3.12.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88191 Genomic DNA. Translation: AAC49903.1. Frameshift.
CU329671 Genomic DNA. Translation: CAA16826.1.
PIRiJC6500.
T40493.
RefSeqiNP_596301.1. NM_001022222.2.

3D structure databases

ProteinModelPortaliO43058.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277383. 112 interactions.

PTM databases

iPTMnetiO43058.

Proteomic databases

MaxQBiO43058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC4C3.12.1; SPBC4C3.12.1:pep; SPBC4C3.12.
GeneIDi2540866.
KEGGispo:SPBC4C3.12.

Organism-specific databases

EuPathDBiFungiDB:SPBC4C3.12.
PomBaseiSPBC4C3.12. sep1.

Phylogenomic databases

InParanoidiO43058.
OrthoDBiEOG7647BS.

Miscellaneous databases

PROiO43058.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "sep1+ encodes a transcription-factor homologue of the HNF-3/forkhead DNA-binding-domain family in Schizosaccharomyces pombe."
    Ribar B., Banrevi A., Sipiczki M.
    Gene 202:1-5(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. Cited for: FUNCTION.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-446, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSEP1_SCHPO
AccessioniPrimary (citable) accession number: O43058
Secondary accession number(s): P79006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.