Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Forkhead protein sep1

Gene

sep1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for promoter sequence element PCB-driven, M-phase-specific transcription. Acts as a transcriptional activator with a role in the regulation of mitosis. Regulates septation and the periodic transcription of cdc15.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi128 – 222Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Mitosis, Septation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead protein sep1
Gene namesi
Name:sep1
ORF Names:SPBC4C3.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4C3.12
PomBaseiSPBC4C3.12 sep1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000919071 – 663Forkhead protein sep1Add BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei446Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43058
PaxDbiO43058
PRIDEiO43058

PTM databases

iPTMnetiO43058

Interactioni

Protein-protein interaction databases

BioGridi277383, 113 interactors
STRINGi4896.SPBC4C3.12.1

Structurei

3D structure databases

ProteinModelPortaliO43058
SMRiO43058
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiO43058
OrthoDBiEOG092C0D3W

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

O43058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFNSTNPYY FTHEKNLNNA SKYSELPIAY QEIPLQSLPP YPKVASKLKG
60 70 80 90 100
VVAGGKENNI ASFQKPSSKA TRPYIPSYTR LTYSVPPLPI PPPSEQSLDT
110 120 130 140 150
IIYRNPSVSS SQSQEPEEFF LPLDDGKKPP YSYAMLIGMS IIRSPDRRLT
160 170 180 190 200
LSAIYDWISN TFSFYNKSNN GWQNSIRHNL SLNKAFMKIE RPRNLPGKGH
210 220 230 240 250
FWSIRPGHEE QFLKLKLRKP GVNSRPAPPV QDVTSSTKYG SSTGSSGFNT
260 270 280 290 300
FNTSPHIFNQ RHQYLQNYYT ASLTNIPTIS NVNATNFHPL HSQQPYVDTP
310 320 330 340 350
GIDAPSDLEA KFSDLGVSSV VSVTSPLQSC TNSPSPPLSS PASSASPSES
360 370 380 390 400
LRNESLGIKS AKSLGLNKDD APVEGPPVSH LEKDVETPSV HDSVLGFNDT
410 420 430 440 450
VTNLGKKGLK DGTTNTLQIP AVRLPSLPSS PTIKNPSGLL LKRSNSIDFP
460 470 480 490 500
TPPKALCPKL FCFRDDIVAD DYTKFSLLSP IRSDMSGISA SPNTNLKEHR
510 520 530 540 550
TRILQMLATP DAKQLSSLTS SDAEFWSVTP LKSSILRNGD ASKQVTLSES
560 570 580 590 600
PKGDSLLDGG SLSYFTNNIS SVAGLETPSK LPMSKSFDTF EDDFLDPMDM
610 620 630 640 650
LSFENHFSDF NSNRKVSPVK REVRRKYISS ATTIHSSAAQ DDTYLPSPTK
660
RKMPLLRQTS TLF
Length:663
Mass (Da):73,032
Last modified:June 1, 1998 - v1
Checksum:iA66099437B7714C2
GO

Sequence cautioni

The sequence AAC49903 differs from that shown. Reason: Frameshift at positions 86, 123 and 583.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377 – 387PVSHLEKDVET → TCITFGEGCCN in AAC49903 (PubMed:9427538).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88191 Genomic DNA Translation: AAC49903.1 Frameshift.
CU329671 Genomic DNA Translation: CAA16826.1
PIRiJC6500
T40493
RefSeqiNP_596301.1, NM_001022222.2

Genome annotation databases

EnsemblFungiiSPBC4C3.12.1; SPBC4C3.12.1:pep; SPBC4C3.12
GeneIDi2540866
KEGGispo:SPBC4C3.12

Entry informationi

Entry nameiSEP1_SCHPO
AccessioniPrimary (citable) accession number: O43058
Secondary accession number(s): P79006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health