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Protein

Probable homoserine kinase

Gene

SPBC4C3.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Probable aspartokinase (SPBC19F5.04)
  2. Probable aspartate-semialdehyde dehydrogenase (SPCC1827.06c)
  3. Probable homoserine dehydrogenase (SPBC776.03)
  4. Probable homoserine kinase (SPBC4C3.03)
  5. Threonine synthase (thrc)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi93 – 103ATPSequence analysisAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable homoserine kinase (EC:2.7.1.39)
Short name:
HK
Short name:
HSK
Gene namesi
ORF Names:SPBC4C3.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4C3.03.
PomBaseiSPBC4C3.03.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001566551 – 338Probable homoserine kinaseAdd BLAST338

Proteomic databases

MaxQBiO43056.
PRIDEiO43056.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-4674968.

Structurei

3D structure databases

ProteinModelPortaliO43056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000247199.
InParanoidiO43056.
KOiK00872.
OMAiCANRIPH.
OrthoDBiEOG092702AT.
PhylomeDBiO43056.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase. 1 hit.
InterProiView protein in InterPro
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PfamiView protein in Pfam
PF00288. GHMP_kinases_N. 1 hit.
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiView protein in PROSITE
PS00627. GHMP_KINASES_ATP. 1 hit.

Sequencei

Sequence statusi: Complete.

O43056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKFQIKVPA SSANIGPGFD VLGMSLEEYM TLDVEVSTES GPCVLTYEGD
60 70 80 90 100
GKEHVSLDVQ KNMITQTSLY VLRCNNISTF PYATKIHVIN PIPLGRGMGS
110 120 130 140 150
SGSAAIAGVM LANEIAKLGL SKLQMMDYVL MIERHPDNVM ASMMGGFVGS
160 170 180 190 200
FLRELSEEEK NAFSPSADDL LKNEALTLPP KSLGTFARLP WASELKAIVV
210 220 230 240 250
IPEFHLATSK ARSVLPTSYG RTDVVYNLQR LALLTTALGQ TPINPHLVYE
260 270 280 290 300
VMKDKVHQPY RASLIPGLQN ILATLNPDTQ PGLCGICLSG AGPTVLALAT
310 320 330
GNFDEIAHAM LSIFEKHGVK CRYLVLSPAF DGATVKYF
Length:338
Mass (Da):36,608
Last modified:June 1, 1998 - v1
Checksum:i17B4F94188F6267B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16824.1.
PIRiT40495.
RefSeqiNP_596303.1. NM_001022224.2.

Genome annotation databases

EnsemblFungiiSPBC4C3.03.1; SPBC4C3.03.1:pep; SPBC4C3.03.
GeneIDi2540857.
KEGGispo:SPBC4C3.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16824.1.
PIRiT40495.
RefSeqiNP_596303.1. NM_001022224.2.

3D structure databases

ProteinModelPortaliO43056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4674968.

Proteomic databases

MaxQBiO43056.
PRIDEiO43056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC4C3.03.1; SPBC4C3.03.1:pep; SPBC4C3.03.
GeneIDi2540857.
KEGGispo:SPBC4C3.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC4C3.03.
PomBaseiSPBC4C3.03.

Phylogenomic databases

HOGENOMiHOG000247199.
InParanoidiO43056.
KOiK00872.
OMAiCANRIPH.
OrthoDBiEOG092702AT.
PhylomeDBiO43056.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.

Miscellaneous databases

PROiO43056.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase. 1 hit.
InterProiView protein in InterPro
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PfamiView protein in Pfam
PF00288. GHMP_kinases_N. 1 hit.
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiView protein in PROSITE
PS00627. GHMP_KINASES_ATP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKHSE_SCHPO
AccessioniPrimary (citable) accession number: O43056
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 1998
Last modified: February 15, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.