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O43049

- PPT1_SCHPO

UniProt

O43049 - PPT1_SCHPO

Protein

Serine/threonine-protein phosphatase T

Gene

ppt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (01 May 1999)
      Previous versions | rss
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    Functioni

    Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi217 – 2171Manganese 1By similarity
    Metal bindingi219 – 2191Manganese 1By similarity
    Metal bindingi246 – 2461Manganese 1By similarity
    Metal bindingi246 – 2461Manganese 2By similarity
    Metal bindingi278 – 2781Manganese 2By similarity
    Active sitei279 – 2791Proton donorBy similarity
    Metal bindingi327 – 3271Manganese 2By similarity
    Metal bindingi404 – 4041Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: PomBase

    GO - Biological processi

    1. protein dephosphorylation Source: PomBase
    2. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase T (EC:3.1.3.16)
    Short name:
    PPT
    Gene namesi
    Name:ppt1
    ORF Names:SPBC3F6.01c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC3F6.01c.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. nucleus Source: PomBase
    3. protein complex Source: PomBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473Serine/threonine-protein phosphatase TPRO_0000363378Add
    BLAST

    Proteomic databases

    MaxQBiO43049.

    Interactioni

    Protein-protein interaction databases

    BioGridi277519. 27 interactions.
    STRINGi4896.SPBC3F6.01c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO43049.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati5 – 3834TPR 1Add
    BLAST
    Repeati40 – 7233TPR 2Add
    BLAST
    Repeati73 – 10634TPR 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni159 – 472314CatalyticBy similarityAdd
    BLAST

    Domaini

    The TPR repeats mediate protein-protein interactions with substrate proteins, but also autoinhibit PPT phosphatase activity.By similarity

    Sequence similaritiesi

    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172698.
    KOiK04460.
    OMAiFKLLYPN.
    OrthoDBiEOG7Z3FDD.
    PhylomeDBiO43049.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR013235. PPP_dom.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    IPR011236. Ser/Thr_PPase_5.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR11668:SF12. PTHR11668:SF12. 1 hit.
    PfamiPF00149. Metallophos. 1 hit.
    PF08321. PPP5. 1 hit.
    PF00515. TPR_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF033096. PPPtase_5. 1 hit.
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    SM00028. TPR. 3 hits.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43049-1 [UniParc]FASTAAdd to Basket

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    MAKEALELKN EANKFLKEGH IVQAIDLYTK AIELDSTNAI LYSNRSLAHL    50
    KSEDYGLAIN DASKAIECDP EYAKAYFRRA TAHIAIFQPK EAVGDFRKAL 100
    ALAPSDPAAR KKLRECEQLV KRIRFQEAIH NTEPPSPLAN INIEDMDIPS 150
    DYDGVILEKQ ITKEFVEDMK ERFCQGKKLP LKFAYSILRD LKELLEKTPS 200
    LIDIPVKGDE TLVICGDTHG QYFDLLNIFK LHGPPSPTNK YLFNGDFVDR 250
    GSWSTEVAFT LYAYKLLYPD AVFINRGNHE TDDMNKVYGF EGECRSKYNE 300
    RTFNIFSETF SLLPLGSLIS DSYLVVHGGL FSDDNVTLDQ LRNIDRFSKK 350
    QPGQSGLMME MLWTDPQPAP GRGPSKRGVG LQFGPDVSKR FCEANGLKAV 400
    IRSHEVRDQG YEVEHDGYCI TVFSAPNYCD STGNLGAVIK VKEDMELDFH 450
    QFEAVPHPNI RPMAYANGLL SGM 473
    Length:473
    Mass (Da):53,291
    Last modified:May 1, 1999 - v2
    Checksum:i752AB4B13E1702FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA17690.2.
    PIRiT40391.
    RefSeqiNP_596740.1. NM_001022666.2.

    Genome annotation databases

    EnsemblFungiiSPBC3F6.01c.1; SPBC3F6.01c.1:pep; SPBC3F6.01c.
    GeneIDi2541004.
    KEGGispo:SPBC3F6.01c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA17690.2 .
    PIRi T40391.
    RefSeqi NP_596740.1. NM_001022666.2.

    3D structure databases

    ProteinModelPortali O43049.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277519. 27 interactions.
    STRINGi 4896.SPBC3F6.01c-1.

    Proteomic databases

    MaxQBi O43049.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC3F6.01c.1 ; SPBC3F6.01c.1:pep ; SPBC3F6.01c .
    GeneIDi 2541004.
    KEGGi spo:SPBC3F6.01c.

    Organism-specific databases

    PomBasei SPBC3F6.01c.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172698.
    KOi K04460.
    OMAi FKLLYPN.
    OrthoDBi EOG7Z3FDD.
    PhylomeDBi O43049.

    Miscellaneous databases

    NextBioi 20802118.
    PROi O43049.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR013235. PPP_dom.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    IPR011236. Ser/Thr_PPase_5.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR11668:SF12. PTHR11668:SF12. 1 hit.
    Pfami PF00149. Metallophos. 1 hit.
    PF08321. PPP5. 1 hit.
    PF00515. TPR_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF033096. PPPtase_5. 1 hit.
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    SM00028. TPR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPPT1_SCHPO
    AccessioniPrimary (citable) accession number: O43049
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3