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Protein

Serine/threonine-protein phosphatase T

Gene

ppt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi217Manganese 1By similarity1
Metal bindingi219Manganese 1By similarity1
Metal bindingi246Manganese 1By similarity1
Metal bindingi246Manganese 2By similarity1
Metal bindingi278Manganese 2By similarity1
Active sitei279Proton donorBy similarity1
Metal bindingi327Manganese 2By similarity1
Metal bindingi404Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase T (EC:3.1.3.16)
Short name:
PPT
Gene namesi
Name:ppt1
ORF Names:SPBC3F6.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC3F6.01c
PomBaseiSPBC3F6.01c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003633781 – 473Serine/threonine-protein phosphatase TAdd BLAST473

Proteomic databases

MaxQBiO43049
PaxDbiO43049
PRIDEiO43049

Interactioni

Protein-protein interaction databases

BioGridi277519, 27 interactors
STRINGi4896.SPBC3F6.01c.1

Structurei

3D structure databases

ProteinModelPortaliO43049
SMRiO43049
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 38TPR 1Add BLAST34
Repeati40 – 72TPR 2Add BLAST33
Repeati73 – 106TPR 3Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni159 – 472CatalyticBy similarityAdd BLAST314

Domaini

The TPR repeats mediate protein-protein interactions with substrate proteins, but also autoinhibit PPT phosphatase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

HOGENOMiHOG000172698
InParanoidiO43049
KOiK04460
OMAiLYPNHFF
OrthoDBiEOG092C1UGR
PhylomeDBiO43049

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR013235 PPP_dom
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR011236 Ser/Thr_PPase_5
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR11668:SF391 PTHR11668:SF391, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF08321 PPP5, 1 hit
PF13181 TPR_8, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O43049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEALELKN EANKFLKEGH IVQAIDLYTK AIELDSTNAI LYSNRSLAHL
60 70 80 90 100
KSEDYGLAIN DASKAIECDP EYAKAYFRRA TAHIAIFQPK EAVGDFRKAL
110 120 130 140 150
ALAPSDPAAR KKLRECEQLV KRIRFQEAIH NTEPPSPLAN INIEDMDIPS
160 170 180 190 200
DYDGVILEKQ ITKEFVEDMK ERFCQGKKLP LKFAYSILRD LKELLEKTPS
210 220 230 240 250
LIDIPVKGDE TLVICGDTHG QYFDLLNIFK LHGPPSPTNK YLFNGDFVDR
260 270 280 290 300
GSWSTEVAFT LYAYKLLYPD AVFINRGNHE TDDMNKVYGF EGECRSKYNE
310 320 330 340 350
RTFNIFSETF SLLPLGSLIS DSYLVVHGGL FSDDNVTLDQ LRNIDRFSKK
360 370 380 390 400
QPGQSGLMME MLWTDPQPAP GRGPSKRGVG LQFGPDVSKR FCEANGLKAV
410 420 430 440 450
IRSHEVRDQG YEVEHDGYCI TVFSAPNYCD STGNLGAVIK VKEDMELDFH
460 470
QFEAVPHPNI RPMAYANGLL SGM
Length:473
Mass (Da):53,291
Last modified:May 1, 1999 - v2
Checksum:i752AB4B13E1702FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA17690.2
PIRiT40391
RefSeqiNP_596740.1, NM_001022666.2

Genome annotation databases

EnsemblFungiiSPBC3F6.01c.1; SPBC3F6.01c.1:pep; SPBC3F6.01c
GeneIDi2541004
KEGGispo:SPBC3F6.01c

Similar proteinsi

Entry informationi

Entry nameiPPT1_SCHPO
AccessioniPrimary (citable) accession number: O43049
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health