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O43049

- PPT1_SCHPO

UniProt

O43049 - PPT1_SCHPO

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Protein
Serine/threonine-protein phosphatase T
Gene
ppt1, SPBC3F6.01c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi217 – 2171Manganese 1 By similarity
Metal bindingi219 – 2191Manganese 1 By similarity
Metal bindingi246 – 2461Manganese 1 By similarity
Metal bindingi246 – 2461Manganese 2 By similarity
Metal bindingi278 – 2781Manganese 2 By similarity
Active sitei279 – 2791Proton donor By similarity
Metal bindingi327 – 3271Manganese 2 By similarity
Metal bindingi404 – 4041Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: PomBase

GO - Biological processi

  1. protein dephosphorylation Source: PomBase
  2. signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase T (EC:3.1.3.16)
Short name:
PPT
Gene namesi
Name:ppt1
ORF Names:SPBC3F6.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC3F6.01c.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. nucleus Source: PomBase
  3. protein complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Serine/threonine-protein phosphatase T
PRO_0000363378Add
BLAST

Proteomic databases

MaxQBiO43049.

Interactioni

Protein-protein interaction databases

BioGridi277519. 27 interactions.
STRINGi4896.SPBC3F6.01c-1.

Structurei

3D structure databases

ProteinModelPortaliO43049.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 3834TPR 1
Add
BLAST
Repeati40 – 7233TPR 2
Add
BLAST
Repeati73 – 10634TPR 3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni159 – 472314Catalytic By similarity
Add
BLAST

Domaini

The TPR repeats mediate protein-protein interactions with substrate proteins, but also autoinhibit PPT phosphatase activity By similarity.

Sequence similaritiesi

Contains 3 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172698.
KOiK04460.
OMAiFKLLYPN.
OrthoDBiEOG7Z3FDD.
PhylomeDBiO43049.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR013235. PPP_dom.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR011236. Ser/Thr_PPase_5.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11668:SF12. PTHR11668:SF12. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
PF00515. TPR_1. 1 hit.
[Graphical view]
PIRSFiPIRSF033096. PPPtase_5. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43049-1 [UniParc]FASTAAdd to Basket

« Hide

MAKEALELKN EANKFLKEGH IVQAIDLYTK AIELDSTNAI LYSNRSLAHL    50
KSEDYGLAIN DASKAIECDP EYAKAYFRRA TAHIAIFQPK EAVGDFRKAL 100
ALAPSDPAAR KKLRECEQLV KRIRFQEAIH NTEPPSPLAN INIEDMDIPS 150
DYDGVILEKQ ITKEFVEDMK ERFCQGKKLP LKFAYSILRD LKELLEKTPS 200
LIDIPVKGDE TLVICGDTHG QYFDLLNIFK LHGPPSPTNK YLFNGDFVDR 250
GSWSTEVAFT LYAYKLLYPD AVFINRGNHE TDDMNKVYGF EGECRSKYNE 300
RTFNIFSETF SLLPLGSLIS DSYLVVHGGL FSDDNVTLDQ LRNIDRFSKK 350
QPGQSGLMME MLWTDPQPAP GRGPSKRGVG LQFGPDVSKR FCEANGLKAV 400
IRSHEVRDQG YEVEHDGYCI TVFSAPNYCD STGNLGAVIK VKEDMELDFH 450
QFEAVPHPNI RPMAYANGLL SGM 473
Length:473
Mass (Da):53,291
Last modified:May 1, 1999 - v2
Checksum:i752AB4B13E1702FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA17690.2.
PIRiT40391.
RefSeqiNP_596740.1. NM_001022666.2.

Genome annotation databases

EnsemblFungiiSPBC3F6.01c.1; SPBC3F6.01c.1:pep; SPBC3F6.01c.
GeneIDi2541004.
KEGGispo:SPBC3F6.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA17690.2 .
PIRi T40391.
RefSeqi NP_596740.1. NM_001022666.2.

3D structure databases

ProteinModelPortali O43049.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277519. 27 interactions.
STRINGi 4896.SPBC3F6.01c-1.

Proteomic databases

MaxQBi O43049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC3F6.01c.1 ; SPBC3F6.01c.1:pep ; SPBC3F6.01c .
GeneIDi 2541004.
KEGGi spo:SPBC3F6.01c.

Organism-specific databases

PomBasei SPBC3F6.01c.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172698.
KOi K04460.
OMAi FKLLYPN.
OrthoDBi EOG7Z3FDD.
PhylomeDBi O43049.

Miscellaneous databases

NextBioi 20802118.
PROi O43049.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR013235. PPP_dom.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR011236. Ser/Thr_PPase_5.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR11668:SF12. PTHR11668:SF12. 1 hit.
Pfami PF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
PF00515. TPR_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF033096. PPPtase_5. 1 hit.
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPPT1_SCHPO
AccessioniPrimary (citable) accession number: O43049
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi