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Protein

Signal recognition particle receptor subunit alpha homolog

Gene

srp101

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. GTP hydrolysis may enhance the fidelity of and provide unidirectionality to the targeting reaction (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi349 – 356GTPBy similarity8
Nucleotide bindingi437 – 441GTPBy similarity5
Nucleotide bindingi498 – 501GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit alpha homolog
Short name:
SR-alpha
Alternative name(s):
Docking protein alpha
Short name:
DP-alpha
Gene namesi
Name:srp101
ORF Names:SPBC3B9.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPBC3B9.03
PomBaseiSPBC3B9.03 srp101

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003160241 – 547Signal recognition particle receptor subunit alpha homologAdd BLAST547

Proteomic databases

MaxQBiO43032
PaxDbiO43032
PRIDEiO43032

PTM databases

iPTMnetiO43032

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Protein-protein interaction databases

STRINGi4896.SPBC3B9.03.1

Structurei

3D structure databases

ProteinModelPortaliO43032
SMRiO43032
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP-binding SRP family.Curated

Phylogenomic databases

HOGENOMiHOG000201671
InParanoidiO43032
KOiK13431
OMAiHKMEDDD
OrthoDBiEOG092C2S7B
PhylomeDBiO43032

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011012 Longin-like_dom_sf
IPR027417 P-loop_NTPase
IPR007222 Sig_recog_particle_rcpt_asu_N
IPR013822 Signal_recog_particl_SRP54_hlx
IPR036225 SRP/SRP_N
IPR000897 SRP54_GTPase_dom
PfamiView protein in Pfam
PF04086 SRP-alpha_N, 2 hits
PF00448 SRP54, 1 hit
PF02881 SRP54_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00962 SRP54, 1 hit
SM00963 SRP54_N, 1 hit
SUPFAMiSSF47364 SSF47364, 1 hit
SSF52540 SSF52540, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00300 SRP54, 1 hit

Sequencei

Sequence statusi: Complete.

O43032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDLFAIVNK GGIVLWKKTN SLVNLKCLQV LFHEAFLSEQ RTVNNTVTFD
60 70 80 90 100
RYTMQYQEAT QYSIVFVVVF QDLKCMAYSQ SLLNSAHNIF LNLFKEKLED
110 120 130 140 150
RQVPNEAEVE KLFAPIFNRK SAQLENETDT KSLPVEANND NSARKKNEYE
160 170 180 190 200
MKKKGAQSKQ TNAPKKGKKQ LRKWDDQITE EEQAALNYSS QASSASQTVD
210 220 230 240 250
NSQLSSIVGN NNKFQKTGSG DVIISDLEMD PNQTISNKSA SSAFSLFSNL
260 270 280 290 300
IGGKYLKEED LSPILKQMQE HLTKKNVANS IALELCESVK ASLINKKVGS
310 320 330 340 350
FDTVKNTVNK AFRDRLTQIL TPSTSLDLLH SIRSVRKNEN RPYTISLIGV
360 370 380 390 400
NGVGKSTTLA KIAYWLLSNN FRILVAACDT FRSGAIEQLG VHVKNLQSLK
410 420 430 440 450
GSSIELFAQG YGKDSSFVVK NAVEYAKQNS FDVILIDTAG RRHNDQRLMG
460 470 480 490 500
SLEKFTKATK LDKIFQVAEA LVGTDSLAQA KHFQASLYHR PLDGFIISKV
510 520 530 540
DTVGQLVGVM VGMVYAVRVP IIFVGIGQTY SDLRTLSVDW VVDQLMK
Length:547
Mass (Da):61,078
Last modified:June 1, 1998 - v1
Checksum:i42E920E528E22361
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA17783.1
PIRiT40342
RefSeqiNP_596660.1, NM_001022582.2

Genome annotation databases

EnsemblFungiiSPBC3B9.03.1; SPBC3B9.03.1:pep; SPBC3B9.03
GeneIDi2540909
KEGGispo:SPBC3B9.03

Entry informationi

Entry nameiSRPR_SCHPO
AccessioniPrimary (citable) accession number: O43032
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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