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Protein

Signal recognition particle receptor subunit alpha homolog

Gene

srp101

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. GTP hydrolysis may enhance the fidelity of and provide unidirectionality to the targeting reaction (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi349 – 3568GTPBy similarity
Nucleotide bindingi437 – 4415GTPBy similarity
Nucleotide bindingi498 – 5014GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit alpha homolog
Short name:
SR-alpha
Alternative name(s):
Docking protein alpha
Short name:
DP-alpha
Gene namesi
Name:srp101
ORF Names:SPBC3B9.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC3B9.03.
PomBaseiSPBC3B9.03. srp101.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • signal recognition particle receptor complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Signal recognition particle receptor subunit alpha homologPRO_0000316024Add
BLAST

Proteomic databases

MaxQBiO43032.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Protein-protein interaction databases

MINTiMINT-4674757.

Structurei

3D structure databases

ProteinModelPortaliO43032.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP-binding SRP family.Curated

Phylogenomic databases

HOGENOMiHOG000201671.
InParanoidiO43032.
KOiK13431.
OMAiACANKEV.
OrthoDBiEOG092C2S7B.
PhylomeDBiO43032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011012. Longin-like_dom.
IPR027417. P-loop_NTPase.
IPR007222. Sig_recog_particle_rcpt_asu_N.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF04086. SRP-alpha_N. 2 hits.
PF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDLFAIVNK GGIVLWKKTN SLVNLKCLQV LFHEAFLSEQ RTVNNTVTFD
60 70 80 90 100
RYTMQYQEAT QYSIVFVVVF QDLKCMAYSQ SLLNSAHNIF LNLFKEKLED
110 120 130 140 150
RQVPNEAEVE KLFAPIFNRK SAQLENETDT KSLPVEANND NSARKKNEYE
160 170 180 190 200
MKKKGAQSKQ TNAPKKGKKQ LRKWDDQITE EEQAALNYSS QASSASQTVD
210 220 230 240 250
NSQLSSIVGN NNKFQKTGSG DVIISDLEMD PNQTISNKSA SSAFSLFSNL
260 270 280 290 300
IGGKYLKEED LSPILKQMQE HLTKKNVANS IALELCESVK ASLINKKVGS
310 320 330 340 350
FDTVKNTVNK AFRDRLTQIL TPSTSLDLLH SIRSVRKNEN RPYTISLIGV
360 370 380 390 400
NGVGKSTTLA KIAYWLLSNN FRILVAACDT FRSGAIEQLG VHVKNLQSLK
410 420 430 440 450
GSSIELFAQG YGKDSSFVVK NAVEYAKQNS FDVILIDTAG RRHNDQRLMG
460 470 480 490 500
SLEKFTKATK LDKIFQVAEA LVGTDSLAQA KHFQASLYHR PLDGFIISKV
510 520 530 540
DTVGQLVGVM VGMVYAVRVP IIFVGIGQTY SDLRTLSVDW VVDQLMK
Length:547
Mass (Da):61,078
Last modified:June 1, 1998 - v1
Checksum:i42E920E528E22361
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA17783.1.
PIRiT40342.
RefSeqiNP_596660.1. NM_001022582.2.

Genome annotation databases

EnsemblFungiiSPBC3B9.03.1; SPBC3B9.03.1:pep; SPBC3B9.03.
GeneIDi2540909.
KEGGispo:SPBC3B9.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA17783.1.
PIRiT40342.
RefSeqiNP_596660.1. NM_001022582.2.

3D structure databases

ProteinModelPortaliO43032.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4674757.

Proteomic databases

MaxQBiO43032.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC3B9.03.1; SPBC3B9.03.1:pep; SPBC3B9.03.
GeneIDi2540909.
KEGGispo:SPBC3B9.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC3B9.03.
PomBaseiSPBC3B9.03. srp101.

Phylogenomic databases

HOGENOMiHOG000201671.
InParanoidiO43032.
KOiK13431.
OMAiACANKEV.
OrthoDBiEOG092C2S7B.
PhylomeDBiO43032.

Miscellaneous databases

PROiO43032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011012. Longin-like_dom.
IPR027417. P-loop_NTPase.
IPR007222. Sig_recog_particle_rcpt_asu_N.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF04086. SRP-alpha_N. 2 hits.
PF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRPR_SCHPO
AccessioniPrimary (citable) accession number: O43032
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.