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Protein

Putative transcription factor sre2

Gene

sre2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative transcription factor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transcription factor sre2
Alternative name(s):
Sterol regulatory element-binding protein 2
Gene namesi
Name:sre2
ORF Names:SPBC354.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC354.05c.
PomBaseiSPBC354.05c. sre2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei719 – 73921HelicalSequence analysisAdd
BLAST
Transmembranei748 – 76821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • integral component of membrane Source: UniProtKB-KW
  • nuclear chromatin Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 793793Putative transcription factor sre2PRO_0000356242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei344 – 3441Phosphoserine1 Publication
Modified residuei345 – 3451Phosphoserine1 Publication
Modified residuei355 – 3551Phosphoserine1 Publication
Modified residuei356 – 3561Phosphotyrosine1 Publication

Post-translational modificationi

May undergo proteolytic cleavage to release the soluble transcription factor from the membrane.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43019.

PTM databases

iPTMnetiO43019.

Interactioni

Protein-protein interaction databases

BioGridi277559. 209 interactions.
MINTiMINT-4674676.

Structurei

3D structure databases

ProteinModelPortaliO43019.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini426 – 49570bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi344 – 40057Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO43019.
OrthoDBiEOG7PS1QH.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPSQHSSLK DIHRQLENTA ISNPTENADP SSYVDGSNIM DFKHPSIVSS
60 70 80 90 100
SASSSYPISH VPSVGTRGIP RSYSMASAYP YQVNSNSMDA STAFNLNQDV
110 120 130 140 150
ADKPMLARNS IDSSINTELG PLESNHWFTQ AQDHSRQYSS SWDPSIDPFE
160 170 180 190 200
VKNSLHDSTD LSITHHPHLP INHQGNTWKH ANESLQSNQG PVPNTKFVGL
210 220 230 240 250
ETTQTDSYQQ SSVNSVVKIE EADATYALRE ESGQFNTFTG AENPSISPHS
260 270 280 290 300
LNPNFPQYTE KPALTLLQSP KQNSNYDTSN FQNSVSDSSM QFTNEGMPSP
310 320 330 340 350
VKGIMSSDDA VAFNFSQYST VYPQNAPENG NEFETPNKLK RTVSSPCASI
360 370 380 390 400
SSKRSYGDIA QDCSYISSKT NGGGPSDSPS SSSTSVRGSV NDSNSPISSS
410 420 430 440 450
ATFAIQSNGV EPVGLSTQEQ NLSPLSKRSA HNMIEKRYRS NLNDKIAELR
460 470 480 490 500
DAVPTLRSGY NSTTADELKG TYVPLSRKLN KATILSKATE YIKSLQSKNK
510 520 530 540 550
KLIEENKILQ KRLSEYTSVI QASLTAPSQP ASLSLLGPPG NTPGHRNVPP
560 570 580 590 600
ILKRSSIGTP SQQAYFPDAP HNCHSVPQNS SYPRPPMQVN RSPIDSMQTI
610 620 630 640 650
PHANFNEMHN AYSSRYPLKY SKSCNAVSHT SMMHPQEYGG SLPSSTVPSD
660 670 680 690 700
YNQPQLVSPR AQADQQGLSY KNVGRAVLNG LVGLETVHML TNPDDAGSSN
710 720 730 740 750
RFSMSVLPIS PSLHSILRFL LLLLAFLCFA MHILLTPEAT LRKWASSIYL
760 770 780 790
SFRLECVFIS FLIFSVPIYD WGNYLNLRGK LLSELNLESG VAT
Length:793
Mass (Da):86,834
Last modified:June 1, 1998 - v1
Checksum:iB9A4E0BBFA79C3A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA17805.1.
PIRiT40285.
RefSeqiNP_595229.1. NM_001021135.2.

Genome annotation databases

EnsemblFungiiSPBC354.05c.1; SPBC354.05c.1:pep; SPBC354.05c.
GeneIDi2541044.
KEGGispo:SPBC354.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA17805.1.
PIRiT40285.
RefSeqiNP_595229.1. NM_001021135.2.

3D structure databases

ProteinModelPortaliO43019.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277559. 209 interactions.
MINTiMINT-4674676.

PTM databases

iPTMnetiO43019.

Proteomic databases

MaxQBiO43019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC354.05c.1; SPBC354.05c.1:pep; SPBC354.05c.
GeneIDi2541044.
KEGGispo:SPBC354.05c.

Organism-specific databases

EuPathDBiFungiDB:SPBC354.05c.
PomBaseiSPBC354.05c. sre2.

Phylogenomic databases

InParanoidiO43019.
OrthoDBiEOG7PS1QH.

Miscellaneous databases

PROiO43019.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Computational prediction of membrane-tethered transcription factors."
    Zupicich J., Brenner S.E., Skarnes W.C.
    Genome Biol. 2:RESEARCH0050.1-RESEARCH0050.6(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PREDICTED FUNCTION.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344; SER-345; SER-355 AND TYR-356, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSRE2_SCHPO
AccessioniPrimary (citable) accession number: O43019
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.