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O43012

- DCTD_SCHPO

UniProt

O43012 - DCTD_SCHPO

Protein

Deoxycytidylate deaminase

Gene

SPBC2G2.13c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Supplies the nucleotide substrate for thymidylate synthetase.By similarity

    Catalytic activityi

    dCMP + H2O = dUMP + NH3.By similarity

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi246 – 2461Zinc; catalyticBy similarity
    Active sitei248 – 2481Proton donorBy similarity
    Metal bindingi273 – 2731Zinc; catalyticBy similarity
    Metal bindingi276 – 2761Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. dCMP deaminase activity Source: PomBase
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. dTMP biosynthetic process Source: PomBase
    2. dUMP biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_227862. Pyrimidine biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxycytidylate deaminase (EC:3.5.4.12)
    Alternative name(s):
    dCMP deaminase
    Gene namesi
    ORF Names:SPBC2G2.13c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC2G2.13c.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Deoxycytidylate deaminasePRO_0000310830Add
    BLAST

    Proteomic databases

    MaxQBiO43012.

    Interactioni

    Protein-protein interaction databases

    BioGridi276867. 72 interactions.
    MINTiMINT-4674632.
    STRINGi4896.SPBC2G2.13c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO43012.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytidine and deoxycytidylate deaminase family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG2131.
    HOGENOMiHOG000217578.
    KOiK01493.
    OrthoDBiEOG7BCNPR.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR015517. dCMP_deaminase-rel.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR11086. PTHR11086. 1 hit.
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF53927. SSF53927. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43012-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTVGLTGPL CSGKDAVVEY LETKHGFNAI FRLPQLNEDG EYIYRTGDLV    50
    LGSVDDLISY LTPRWRERFV INGIHSPRLL SALLKRPFFL LVYIDAPIML 100
    RFNRYKTYSS LANTTLEEFC SIQDAAAFQS DNAGTRHRAL ANLLINNDSN 150
    IKLHLWEKLQ KADLLNPNRF RPSWDSYFME MASLAAKRSN CMKRRVGCVL 200
    VRGNRVIATG YNGTPRGATN CNEGGCPRCN SASSCGKELD TCLCLHAEEN 250
    ALLEAGRERV GNNAILYCDT CPCLTCSVKI TQLGIKEVVY HTSYNMDSHT 300
    ASLLQAAGVQ LRQYIPPENS IF 322
    Length:322
    Mass (Da):35,974
    Last modified:February 22, 2012 - v2
    Checksum:i61047656CC738B69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA17893.2.
    PIRiT40152.
    RefSeqiNP_596442.2. NM_001022361.2.

    Genome annotation databases

    EnsemblFungiiSPBC2G2.13c.1; SPBC2G2.13c.1:pep; SPBC2G2.13c.
    GeneIDi2540338.
    KEGGispo:SPBC2G2.13c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA17893.2 .
    PIRi T40152.
    RefSeqi NP_596442.2. NM_001022361.2.

    3D structure databases

    ProteinModelPortali O43012.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276867. 72 interactions.
    MINTi MINT-4674632.
    STRINGi 4896.SPBC2G2.13c-1.

    Proteomic databases

    MaxQBi O43012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC2G2.13c.1 ; SPBC2G2.13c.1:pep ; SPBC2G2.13c .
    GeneIDi 2540338.
    KEGGi spo:SPBC2G2.13c.

    Organism-specific databases

    PomBasei SPBC2G2.13c.

    Phylogenomic databases

    eggNOGi COG2131.
    HOGENOMi HOG000217578.
    KOi K01493.
    OrthoDBi EOG7BCNPR.

    Enzyme and pathway databases

    Reactomei REACT_227862. Pyrimidine biosynthesis.

    Miscellaneous databases

    NextBioi 20801466.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR015517. dCMP_deaminase-rel.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR11086. PTHR11086. 1 hit.
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF53927. SSF53927. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Comparative functional genomics of the fission yeasts."
      Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
      , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
      Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVISION OF GENE MODEL.
    3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDCTD_SCHPO
    AccessioniPrimary (citable) accession number: O43012
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3