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O43012

- DCTD_SCHPO

UniProt

O43012 - DCTD_SCHPO

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Protein
Deoxycytidylate deaminase
Gene
SPBC2G2.13c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Supplies the nucleotide substrate for thymidylate synthetase By similarity.By similarity

Catalytic activityi

dCMP + H2O = dUMP + NH3.By similarity

Cofactori

Zinc By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi246 – 2461Zinc; catalytic By similarity
Active sitei248 – 2481Proton donor By similarity
Metal bindingi273 – 2731Zinc; catalytic By similarity
Metal bindingi276 – 2761Zinc; catalytic By similarity

GO - Molecular functioni

  1. dCMP deaminase activity Source: PomBase
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. dTMP biosynthetic process Source: PomBase
  2. dUMP biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_227862. Pyrimidine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
ORF Names:SPBC2G2.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC2G2.13c.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Deoxycytidylate deaminase
PRO_0000310830Add
BLAST

Proteomic databases

MaxQBiO43012.

Interactioni

Protein-protein interaction databases

BioGridi276867. 72 interactions.
MINTiMINT-4674632.
STRINGi4896.SPBC2G2.13c-1.

Structurei

3D structure databases

ProteinModelPortaliO43012.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2131.
HOGENOMiHOG000217578.
KOiK01493.
OrthoDBiEOG7BCNPR.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR015517. dCMP_deaminase-rel.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43012-1 [UniParc]FASTAAdd to Basket

« Hide

MPTVGLTGPL CSGKDAVVEY LETKHGFNAI FRLPQLNEDG EYIYRTGDLV    50
LGSVDDLISY LTPRWRERFV INGIHSPRLL SALLKRPFFL LVYIDAPIML 100
RFNRYKTYSS LANTTLEEFC SIQDAAAFQS DNAGTRHRAL ANLLINNDSN 150
IKLHLWEKLQ KADLLNPNRF RPSWDSYFME MASLAAKRSN CMKRRVGCVL 200
VRGNRVIATG YNGTPRGATN CNEGGCPRCN SASSCGKELD TCLCLHAEEN 250
ALLEAGRERV GNNAILYCDT CPCLTCSVKI TQLGIKEVVY HTSYNMDSHT 300
ASLLQAAGVQ LRQYIPPENS IF 322
Length:322
Mass (Da):35,974
Last modified:February 22, 2012 - v2
Checksum:i61047656CC738B69
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA17893.2.
PIRiT40152.
RefSeqiNP_596442.2. NM_001022361.2.

Genome annotation databases

EnsemblFungiiSPBC2G2.13c.1; SPBC2G2.13c.1:pep; SPBC2G2.13c.
GeneIDi2540338.
KEGGispo:SPBC2G2.13c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA17893.2 .
PIRi T40152.
RefSeqi NP_596442.2. NM_001022361.2.

3D structure databases

ProteinModelPortali O43012.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276867. 72 interactions.
MINTi MINT-4674632.
STRINGi 4896.SPBC2G2.13c-1.

Proteomic databases

MaxQBi O43012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC2G2.13c.1 ; SPBC2G2.13c.1:pep ; SPBC2G2.13c .
GeneIDi 2540338.
KEGGi spo:SPBC2G2.13c.

Organism-specific databases

PomBasei SPBC2G2.13c.

Phylogenomic databases

eggNOGi COG2131.
HOGENOMi HOG000217578.
KOi K01493.
OrthoDBi EOG7BCNPR.

Enzyme and pathway databases

Reactomei REACT_227862. Pyrimidine biosynthesis.

Miscellaneous databases

NextBioi 20801466.

Family and domain databases

InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR015517. dCMP_deaminase-rel.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR11086. PTHR11086. 1 hit.
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDCTD_SCHPO
AccessioniPrimary (citable) accession number: O43012
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 22, 2012
Last modified: September 3, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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