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Protein

Deoxycytidylate deaminase

Gene

SPBC2G2.13c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Supplies the nucleotide substrate for thymidylate synthetase.By similarity

Catalytic activityi

dCMP + H2O = dUMP + NH3.By similarity

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi246Zinc; catalyticBy similarity1
Active sitei248Proton donorBy similarity1
Metal bindingi273Zinc; catalyticBy similarity1
Metal bindingi276Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
ORF Names:SPBC2G2.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2G2.13c
PomBaseiSPBC2G2.13c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003108301 – 322Deoxycytidylate deaminaseAdd BLAST322

Proteomic databases

MaxQBiO43012
PaxDbiO43012
PRIDEiO43012

Interactioni

Protein-protein interaction databases

BioGridi276867, 72 interactors
STRINGi4896.SPBC2G2.13c.1

Structurei

3D structure databases

ProteinModelPortaliO43012
SMRiO43012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 311CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST139

Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.Sequence analysis

Phylogenomic databases

HOGENOMiHOG000217578
InParanoidiO43012
KOiK01493
OMAiCSIKIVQ
OrthoDBiEOG092C46M0

Family and domain databases

CDDicd01286 deoxycytidylate_deaminase, 1 hit
InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
IPR015517 dCMP_deaminase-rel
IPR035105 Deoxycytidylate_deaminase_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11086 PTHR11086, 1 hit
PfamiView protein in Pfam
PF00383 dCMP_cyt_deam_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

O43012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTVGLTGPL CSGKDAVVEY LETKHGFNAI FRLPQLNEDG EYIYRTGDLV
60 70 80 90 100
LGSVDDLISY LTPRWRERFV INGIHSPRLL SALLKRPFFL LVYIDAPIML
110 120 130 140 150
RFNRYKTYSS LANTTLEEFC SIQDAAAFQS DNAGTRHRAL ANLLINNDSN
160 170 180 190 200
IKLHLWEKLQ KADLLNPNRF RPSWDSYFME MASLAAKRSN CMKRRVGCVL
210 220 230 240 250
VRGNRVIATG YNGTPRGATN CNEGGCPRCN SASSCGKELD TCLCLHAEEN
260 270 280 290 300
ALLEAGRERV GNNAILYCDT CPCLTCSVKI TQLGIKEVVY HTSYNMDSHT
310 320
ASLLQAAGVQ LRQYIPPENS IF
Length:322
Mass (Da):35,974
Last modified:February 22, 2012 - v2
Checksum:i61047656CC738B69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA17893.2
PIRiT40152
RefSeqiNP_596442.2, NM_001022361.2

Genome annotation databases

EnsemblFungiiSPBC2G2.13c.1; SPBC2G2.13c.1:pep; SPBC2G2.13c
GeneIDi2540338
KEGGispo:SPBC2G2.13c

Similar proteinsi

Entry informationi

Entry nameiDCTD_SCHPO
AccessioniPrimary (citable) accession number: O43012
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health