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Protein

Histidine--tRNA ligase, mitochondrial

Gene

hts1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.By similarity

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligase, mitochondrial (EC:6.1.1.21)
Alternative name(s):
Histidyl-tRNA synthetase
Short name:
HisRS
Gene namesi
Name:hts1
ORF Names:SPBC2G2.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2G2.12
PomBaseiSPBC2G2.12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000031475526 – 563Histidine--tRNA ligase, mitochondrialAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43011
PaxDbiO43011
PRIDEiO43011

PTM databases

iPTMnetiO43011

Interactioni

Protein-protein interaction databases

BioGridi277000, 6 interactors
STRINGi4896.SPBC2G2.12.1

Structurei

3D structure databases

SMRiO43011
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 85WHEP-TRSPROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000018075
InParanoidiO43011
KOiK01892
OMAiCDFDFIG
OrthoDBiEOG092C1ISK

Family and domain databases

CDDicd00859 HisRS_anticodon, 1 hit
Gene3Di3.40.50.800, 1 hit
InterProiView protein in InterPro
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR015807 His-tRNA-ligase
IPR004516 HisRS/HisZ
IPR033656 HisRS_anticodon
IPR009068 S15_NS1_RNA-bd
IPR000738 WHEP-TRS_dom
PANTHERiPTHR11476 PTHR11476, 1 hit
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF00458 WHEP-TRS, 1 hit
SMARTiView protein in SMART
SM00991 WHEP-TRS, 1 hit
SUPFAMiSSF47060 SSF47060, 1 hit
TIGRFAMsiTIGR00442 hisS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit
PS00762 WHEP_TRS_1, 1 hit
PS51185 WHEP_TRS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVFTKNLFT TKFSSSLLNW RFLRTMADSL VDINERITSQ GNLVRSLKSQ
60 70 80 90 100
GASKEDIDKE VAKLLQLKNL KLGGSEVSGK KKDTSFTLKT PKGTKDWCDK
110 120 130 140 150
DVVLREHIFS TVTEIFKRHG GVTLDTPVFE LKEILSGKYG EDSKLIYDLK
160 170 180 190 200
DQGGELCSLR YDLTVPFARW LAMNPKVTSI KRFHIAKVYR RDQPAMTKGR
210 220 230 240 250
MREFYQCDFD IAGNYDPMIP DSEALKVLVE ALDALEVGNY TIKLNHRKIL
260 270 280 290 300
DGIFTVCGVP DDKIRTISSA VDKLDKLPWE DVRREMVVEK GLKEEVADKI
310 320 330 340 350
KEYVLLKGDR SLLDKLEADS LLSSNSSAVA AFNDMRLLFD YLEAFGVLDR
360 370 380 390 400
FSFDMSLARG LDYYTGIIYE AVTEASAPKI KSSAEKKKSA DPEADRSNDD
410 420 430 440 450
SIGVGSIAAG GRYDNLVGMF AAKKNAKIPC VGISLGLERI FSILRSKIPD
460 470 480 490 500
EDIRANDVDV FVMAFGGGKE WTGFLKERMS VCKDLWANGI KAEFLYKVKP
510 520 530 540 550
KPRQQFDAAD KFDVPFAVIL GQDEFAKGSV RIKQMGLKEN SDEGQLVPRE
560
EMVSVLKKLL KYD
Length:563
Mass (Da):63,305
Last modified:October 3, 2012 - v2
Checksum:iDD0FC33F27AB449B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA17892.2
PIRiT40151
RefSeqiNP_596441.2, NM_001022360.2

Genome annotation databases

EnsemblFungiiSPBC2G2.12.1; SPBC2G2.12.1:pep; SPBC2G2.12
GeneIDi2540472
KEGGispo:SPBC2G2.12

Similar proteinsi

Entry informationi

Entry nameiSYH_SCHPO
AccessioniPrimary (citable) accession number: O43011
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2012
Last modified: June 20, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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