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Protein

Pantothenate transporter liz1

Gene

liz1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transports pantothenate into the cell.1 Publication

GO - Molecular functioni

  • pantothenate transmembrane transporter activity Source: PomBase

GO - Biological processi

  • pantothenate import into cell Source: PomBase
  • pantothenate transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.14.17. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate transporter liz1
Gene namesi
Name:liz1
ORF Names:SPBC2G2.01c, SPBC4B4.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2G2.01c.
PomBaseiSPBC2G2.01c. liz1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421HelicalSequence analysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence analysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence analysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence analysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence analysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence analysisAdd
BLAST
Transmembranei329 – 34921HelicalSequence analysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence analysisAdd
BLAST
Transmembranei390 – 41021HelicalSequence analysisAdd
BLAST
Transmembranei423 – 44321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: PomBase
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Pantothenate transporter liz1PRO_0000121370Add
BLAST

Proteomic databases

MaxQBiO43000.

Interactioni

Protein-protein interaction databases

BioGridi276871. 65 interactions.
MINTiMINT-4674496.

Structurei

3D structure databases

ProteinModelPortaliO43000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000179304.
InParanoidiO43000.
KOiK03448.
OMAiSWANDIC.
OrthoDBiEOG7SV14V.
PhylomeDBiO43000.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLNRLAKT FSPYYGLNKV EQKLLIKIDW FILSYCCVSY FINYLDRSSI
60 70 80 90 100
NNAYLSGMQE DLKMHGNELQ DINVVFTCGY IIGQLPGSYA LQRVPARLWF
110 120 130 140 150
SVMNILWGLM TIFSFAVHSV RALMILRFFM AVAEASTFAG THYILGAWYK
160 170 180 190 200
ESELCKRAGI FSASGLVGTM FAGYLQTAVH SSLNGKGGLS GWRWLFIIDG
210 220 230 240 250
ILTIPLSLYG LFLFPDVPET TKAPYFTEQE KELSFKRLPA RPKKKPLTLK
260 270 280 290 300
AIKDIVRSWR IYGLCILWIF SGETQAIAVN VLMGQWMKWS NKFSVAQINN
310 320 330 340 350
YPTVITAVGV VSTLGASVIS DKLAGNPRWP FGLFLCVITT VSATILLAWN
360 370 380 390 400
VPDGAKFFAY FASGCTYAGQ AVWFSWANDI CRDNDQERGV VVFLMNMCQN
410 420 430 440 450
IWHIWWAPIM YPNTDTPRFI KGLIGLLVVG GIVFVSSCIV SYMQIRDKRI
460 470 480 490 500
KRSIQDAKDF DDVFTEHESL ELKKIGKNDE ESLNTTNAVK EISSPGLVIT
510
RQRISMPKET NAQD
Length:514
Mass (Da):57,964
Last modified:August 1, 1999 - v2
Checksum:iA4026A704EC1FECB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti445 – 4473IRD → SAI in BAA13885 (PubMed:9501991).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052688 Genomic DNA. Translation: AAC06236.1.
CU329671 Genomic DNA. Translation: CAA19293.1.
D89224 mRNA. Translation: BAA13885.1.
PIRiT40485.
RefSeqiNP_596430.1. NM_001022349.2.

Genome annotation databases

EnsemblFungiiSPBC2G2.01c.1; SPBC2G2.01c.1:pep; SPBC2G2.01c.
GeneIDi2540342.
KEGGispo:SPBC2G2.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052688 Genomic DNA. Translation: AAC06236.1.
CU329671 Genomic DNA. Translation: CAA19293.1.
D89224 mRNA. Translation: BAA13885.1.
PIRiT40485.
RefSeqiNP_596430.1. NM_001022349.2.

3D structure databases

ProteinModelPortaliO43000.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276871. 65 interactions.
MINTiMINT-4674496.

Protein family/group databases

TCDBi2.A.1.14.17. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBiO43000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC2G2.01c.1; SPBC2G2.01c.1:pep; SPBC2G2.01c.
GeneIDi2540342.
KEGGispo:SPBC2G2.01c.

Organism-specific databases

EuPathDBiFungiDB:SPBC2G2.01c.
PomBaseiSPBC2G2.01c. liz1.

Phylogenomic databases

HOGENOMiHOG000179304.
InParanoidiO43000.
KOiK03448.
OMAiSWANDIC.
OrthoDBiEOG7SV14V.
PhylomeDBiO43000.

Miscellaneous databases

NextBioi20801470.
PROiO43000.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Liz1p, a novel fission yeast membrane protein, is required for normal cell division when ribonucleotide reductase is inhibited."
    Moynihan E.B., Enoch T.
    Mol. Biol. Cell 10:245-257(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 144-448.
    Strain: PR745.
  4. "Cell division defects of Schizosaccharomyces pombe liz1- mutants are caused by defects in pantothenate uptake."
    Stolz J., Caspari T., Carr A.M., Sauer N.
    Eukaryot. Cell 3:406-412(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiLIZ1_SCHPO
AccessioniPrimary (citable) accession number: O43000
Secondary accession number(s): P78874, Q1L845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: August 1, 1999
Last modified: May 11, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.