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Protein

MADS-box transcription factor 1

Gene

mbx1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator with a role in the regulation of mitosis. Regulates septation and the periodic transcription of cdc15.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MADS-box transcription factor 1
Gene namesi
Name:mbx1
ORF Names:SPBC19G7.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC19G7.06.
PomBaseiSPBC19G7.06. mbx1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • cytosol Source: PomBase
  • M/G1 phase-specific MADS box-forkhead transcription factor complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457MADS-box transcription factor 1PRO_0000199443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei372 – 3721Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated. Occurs periodically during mitosis.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO42954.

PTM databases

iPTMnetiO42954.
SwissPalmiO42954.

Interactioni

Protein-protein interaction databases

BioGridi277168. 55 interactions.
MINTiMINT-4674253.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 7161MADS-boxPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi206 – 2127Poly-Ser

Sequence similaritiesi

Contains 1 MADS-box domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO42954.
OrthoDBiEOG092C1PUJ.

Family and domain databases

InterProiIPR002100. TF_MADSbox.
[Graphical view]
PfamiPF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDINPPPSTA PSSPRRSIQR ISDAKNKALT FNRRRLGLIK KAHELSVLCD
60 70 80 90 100
AKVVVMIFDS KNACHVYSSE EPEEQRDALL QKFLNKDFVT VDPLRNINPN
110 120 130 140 150
IPSDESLHNW RPKDKRIASV TTYSAQPSNN CSSATDSEND FQSFTIKSST
160 170 180 190 200
TYHTTPTTAS ENKKIESITI PDHASVYNDL PLSPTVKHSF VSPVSGDYSD
210 220 230 240 250
SPLEPSSSSS FSVPPESLNP TLSFQHNDVP QTDNFIPFLT PKRQAYGQSS
260 270 280 290 300
SRADRSSVRR SQSFKNRRNG KPRISRLHTS HASIDGLTDF IQSPSSGYLD
310 320 330 340 350
PSSTPITPLD SAINQITPPF LPDNLGQENR GELYSHDNPT SMVYEHPKFD
360 370 380 390 400
ELPNGFIDTH ELNILSRSFT ASPNQILRES NMVNQDSFTD NPVDATWDAL
410 420 430 440 450
IGTTQIDLDL DYERSSIPSS TIPADQLKDG VPTNSVYRNN MVDHNLYPSL

NIERNAP
Length:457
Mass (Da):50,907
Last modified:September 22, 2009 - v2
Checksum:i23466BEE2DC2A3CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA17060.2.
PIRiT39837.
RefSeqiNP_595972.2. NM_001021880.3.

Genome annotation databases

EnsemblFungiiSPBC19G7.06.1; SPBC19G7.06.1:pep; SPBC19G7.06.
GeneIDi2540643.
KEGGispo:SPBC19G7.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA17060.2.
PIRiT39837.
RefSeqiNP_595972.2. NM_001021880.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277168. 55 interactions.
MINTiMINT-4674253.

PTM databases

iPTMnetiO42954.
SwissPalmiO42954.

Proteomic databases

MaxQBiO42954.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC19G7.06.1; SPBC19G7.06.1:pep; SPBC19G7.06.
GeneIDi2540643.
KEGGispo:SPBC19G7.06.

Organism-specific databases

EuPathDBiFungiDB:SPBC19G7.06.
PomBaseiSPBC19G7.06. mbx1.

Phylogenomic databases

InParanoidiO42954.
OrthoDBiEOG092C1PUJ.

Miscellaneous databases

PROiO42954.

Family and domain databases

InterProiIPR002100. TF_MADSbox.
[Graphical view]
PfamiPF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMBX1_SCHPO
AccessioniPrimary (citable) accession number: O42954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: September 22, 2009
Last modified: September 7, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.