Reviewed, UniProtKB/Swiss-Prot O42941 (CYP7_SCHPO)

Names and origin

Protein names

Recommended name:
    Peptidylprolyl isomerase cyp7
    EC=5.2.1.8
Alternative name(s):
    Cyclophilin 7
    Complexed with cdc5 protein 27

Gene names

Name:	cyp7
Synonyms:	cwf27
ORF Names:	SPBC16H5.05c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit structure	Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the cyclophilin-type PPIase family. CWC27 subfamily. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Cytoplasm Nucleus Spliceosome
Molecular function	Isomerase Rotamase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nuclear mRNA splicing, via spliceosome Inferred by curator. Source: GeneDB_SPombe protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell spliceosomal complex Ref.2 Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Peptidylprolyl isomerase cyp7		PRO_0000064178
Regions
	Domain	11 – 166	156	PPIase cyclophilin-type
	Compositional bias	235 – 318	84	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	O42941-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: D7A3148A3CD74A83	FASTA	463	52,174
	10 20 30 40 50 60 MATLTNLEPL ATGTVILKTT RGDIQIELWC KEVPKACRNF IQLCLEGYYD GTIVHRVVPE 70 80 90 100 110 120 FLIQGGDPTG TGMGGESIYG EPFAVETHPR LRFIRRGLVG MACTENEGNN SQFFITLGPT 130 140 150 160 170 180 PEWNGKQTLF GRVVGDTIYN VVRISELELD ANQRPVFPPK IISTEVIDNY FTDIKPRSTK 190 200 210 220 230 240 EEREKIANEL AHQEKQKERN KLLKSGRRNK AVLSFGDEVD MPIVKKPLRQ KTPVSRSSDT 250 260 270 280 290 300 TTELSKDLIS SSSSIHSTYS SAQTGLTSAK VSSDEYARQV DTLDTKLNSS SKSKVQEEIS 310 320 330 340 350 360 RLKSELRDLE KSGGSSNSKP VVVRPKKRNI LTEELEKYKK SKKVVLGKRK NLENDEESTL 370 380 390 400 410 420 RALSSFQSKI RNAEDEDVMD SQYGSKIEDT PCSLHNVPGC FSCFDRLGEK NITETNSNWF 430 440 450 460 AHRLVAENDP TRRTEELRIQ RAEELKDVPS ARPKKLLMKR DII

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.
[2]	"Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs." Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L. Mol. Cell. Biol. 22:2011-2024(2002) [PubMed: 11884590] [Abstract] Cited for: MASS SPECTROMETRY, IDENTIFICATION IN THE CWF COMPLEX.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329671 Genomic DNA. Translation: CAA17903.1.
PIR	T39621.
RefSeq	NP_595943.1.
3D structure databases
HSSP	HSSP built from PDB template 1QNG based on UniProtKB Q25756.
ModBase	Search...
Genome annotation databases
GeneID	2540067.
GenomeReviews	Gene locus cyp7 in contig CU329671_GR.
KEGG	spo:SPBC16H5.05c.
NMPDR	fig|4896.1.peg.1809.
Organism-specific databases
GeneDB_Spombe	SPBC16H5.05c.
Phylogenomic databases
OMA	RENEASE.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-004008-MON.
BRENDA	5.2.1.8. 653.
Gene expression databases
ArrayExpress	O42941.
Family and domain databases
InterPro	IPR002130. PPIase_cyclophilin. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYP7_SCHPO

Accession

Primary (citable) accession number: O42941

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	June 1, 1998
Last modified:	November 3, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)