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O42933

- PMT4_SCHPO

UniProt

O42933 - PMT4_SCHPO

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Protein
Dolichyl-phosphate-mannose--protein mannosyltransferase 4
Gene
ogm4, oma4, SPBC16C6.09
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Required for normal cell wall and septum formation.2 Publications

Catalytic activityi

Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall mannoprotein biosynthetic process Source: PomBase
  2. protein O-linked mannosylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.109. 5615.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-phosphate-mannose--protein mannosyltransferase 4 (EC:2.4.1.109)
Gene namesi
Name:ogm4
Synonyms:oma4
ORF Names:SPBC16C6.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC16C6.09.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8021Helical; Reviewed prediction
Add
BLAST
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Transmembranei196 – 21621Helical; Reviewed prediction
Add
BLAST
Transmembranei223 – 24321Helical; Reviewed prediction
Add
BLAST
Transmembranei248 – 26821Helical; Reviewed prediction
Add
BLAST
Transmembranei288 – 30821Helical; Reviewed prediction
Add
BLAST
Transmembranei608 – 62821Helical; Reviewed prediction
Add
BLAST
Transmembranei644 – 66421Helical; Reviewed prediction
Add
BLAST
Transmembranei669 – 68921Helical; Reviewed prediction
Add
BLAST
Transmembranei726 – 74621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. dolichyl-phosphate-mannose-protein mannosyltransferase complex Source: PomBase
  2. endomembrane system Source: PomBase
  3. endoplasmic reticulum Source: PomBase
  4. endoplasmic reticulum membrane Source: PomBase
  5. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 778778Dolichyl-phosphate-mannose--protein mannosyltransferase 4
PRO_0000121500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi335 – 3351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO42933.

Interactioni

Protein-protein interaction databases

BioGridi276312. 1 interaction.
MINTiMINT-4674080.
STRINGi4896.SPBC16C6.09-1.

Structurei

3D structure databases

ProteinModelPortaliO42933.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini336 – 39661MIR 1
Add
BLAST
Domaini408 – 46760MIR 2
Add
BLAST
Domaini474 – 52956MIR 3
Add
BLAST

Sequence similaritiesi

Contains 3 MIR domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000157526.
KOiK00728.
OMAiHVPYVGM.
OrthoDBiEOG7BP89X.
PhylomeDBiO42933.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 2 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42933-1 [UniParc]FASTAAdd to Basket

« Hide

MASKSEKAVK KAQKLSKEPS VELTDTKSSD NVTPKQKSPN STEEDVSLNL    50
KTLKAKKFKL AFVLITVLSF ITRFWNLNLP GEVVFDEVHF GKFASYYLQG 100
KYFFDLHPPF AKLLLALVAK LAGYDGHYLF DNIGDNYKDN GVPYVTIRAW 150
PALLSSLVPP VVFLIMKESG YDLLACIVSS SLVLFDNAHV TEGRLILLDA 200
TLLFSMVCAI YCYVRFFKLR HTPFSRPWWA WLFFTGFFLS CTISTKYVGF 250
FTFLSIGLSV CLELWYLWDI KTGLTVERFF QHFLARFFCL IFFPFLFFLF 300
WFYMHFNILT ISGPGDSFMS LEFQETLSDN PITANSTILN YYDIVTIKHM 350
GTNAFLHSHP EKYPIPYDDG RISSGGQQVT GYQFDDENNY WMILPADHYD 400
PPIEAKLNVP VKNMDYIKLH HVGTNTDLMT HDVASPYHPT NEEFTTVSVD 450
ESAGKKHEYT LFQVVMSDNT DPQRPLYTKA SSFKLIHKLT HVAMWSDPKP 500
LPDWAFKQLE INGAKNIQTG SIFWTFDDII GLKDSRLKKE KKIPKKLPFW 550
KKYLELQLTM FRQNNMLTEF HPYSSNPSDW FTLHHGIAFW AKSEENKQIY 600
LLGNPIGWWI IAGTVLSTTV VAAAEILLRQ RGIRTLPETV RNHFYRSTMF 650
FYMTYVFHYL PFFIMGRQLF LHHYLPAHLA GSLLVGAFIQ LACRKSFRSP 700
VSAGVPIPKD VDEKGHSKCH RKYGHVIELI CTLLLIFVVI YCFTFFAPMT 750
YGDKSLSVDE WTRRKWLDSW VFQYQKQN 778
Length:778
Mass (Da):90,091
Last modified:June 1, 1998 - v1
Checksum:i7A0A79377D2AA8A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA16916.1.
AB027986 Genomic DNA. Translation: BAA87290.1.
PIRiT39560.
RefSeqiNP_596807.1. NM_001023828.2.

Genome annotation databases

EnsemblFungiiSPBC16C6.09.1; SPBC16C6.09.1:pep; SPBC16C6.09.
GeneIDi2539761.
KEGGispo:SPBC16C6.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA16916.1 .
AB027986 Genomic DNA. Translation: BAA87290.1 .
PIRi T39560.
RefSeqi NP_596807.1. NM_001023828.2.

3D structure databases

ProteinModelPortali O42933.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276312. 1 interaction.
MINTi MINT-4674080.
STRINGi 4896.SPBC16C6.09-1.

Protein family/group databases

CAZyi GT39. Glycosyltransferase Family 39.

Proteomic databases

MaxQBi O42933.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC16C6.09.1 ; SPBC16C6.09.1:pep ; SPBC16C6.09 .
GeneIDi 2539761.
KEGGi spo:SPBC16C6.09.

Organism-specific databases

PomBasei SPBC16C6.09.

Phylogenomic databases

HOGENOMi HOG000157526.
KOi K00728.
OMAi HVPYVGM.
OrthoDBi EOG7BP89X.
PhylomeDBi O42933.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BRENDAi 2.4.1.109. 5615.

Miscellaneous databases

NextBioi 20800911.
PROi O42933.

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
Pfami PF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view ]
SMARTi SM00472. MIR. 2 hits.
[Graphical view ]
SUPFAMi SSF82109. SSF82109. 1 hit.
PROSITEi PS50919. MIR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-105, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.
  3. "Characterization of O-mannosyltransferase family in Schizosaccharomyces pombe."
    Tanaka N., Fujita Y., Suzuki S., Morishita M., Giga-Hama Y., Shimoda C., Takegawa K.
    Biochem. Biophys. Res. Commun. 330:813-820(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "Protein O-mannosylation is crucial for cell wall integrity, septation and viability in fission yeast."
    Willer T., Brandl M., Sipiczki M., Strahl S.
    Mol. Microbiol. 57:156-170(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPMT4_SCHPO
AccessioniPrimary (citable) accession number: O42933
Secondary accession number(s): Q9US82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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