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Protein

Dolichyl-phosphate-mannose--protein mannosyltransferase 4

Gene

ogm4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Required for normal cell wall and septum formation.2 Publications

Catalytic activityi

Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • cell wall mannoprotein biosynthetic process Source: PomBase
  • ER-associated misfolded protein catabolic process Source: GO_Central
  • fungal-type cell wall organization Source: GO_Central
  • protein O-linked mannosylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.109. 5613.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-phosphate-mannose--protein mannosyltransferase 4 (EC:2.4.1.109)
Gene namesi
Name:ogm4
Synonyms:oma4
ORF Names:SPBC16C6.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16C6.09.
PomBaseiSPBC16C6.09. ogm4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Transmembranei608 – 628HelicalSequence analysisAdd BLAST21
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Transmembranei669 – 689HelicalSequence analysisAdd BLAST21
Transmembranei726 – 746HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex Source: GO_Central
  • endomembrane system Source: PomBase
  • endoplasmic reticulum Source: PomBase
  • endoplasmic reticulum membrane Source: PomBase
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001215001 – 778Dolichyl-phosphate-mannose--protein mannosyltransferase 4Add BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Glycosylationi335N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO42933.
PRIDEiO42933.

Interactioni

Protein-protein interaction databases

BioGridi276312. 2 interactors.
MINTiMINT-4674080.

Structurei

3D structure databases

ProteinModelPortaliO42933.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini336 – 396MIR 1PROSITE-ProRule annotationAdd BLAST61
Domaini408 – 467MIR 2PROSITE-ProRule annotationAdd BLAST60
Domaini474 – 529MIR 3PROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Belongs to the glycosyltransferase 39 family.Curated
Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000157526.
InParanoidiO42933.
KOiK00728.
OMAiFWTQNDT.
OrthoDBiEOG092C0JF4.
PhylomeDBiO42933.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39-like.
IPR003342. Glyco_trans_39/83.
IPR016093. MIR_motif.
IPR032421. PMT_4TMC.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 2 hits.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
PF16192. PMT_4TMC. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 2 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42933-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKSEKAVK KAQKLSKEPS VELTDTKSSD NVTPKQKSPN STEEDVSLNL
60 70 80 90 100
KTLKAKKFKL AFVLITVLSF ITRFWNLNLP GEVVFDEVHF GKFASYYLQG
110 120 130 140 150
KYFFDLHPPF AKLLLALVAK LAGYDGHYLF DNIGDNYKDN GVPYVTIRAW
160 170 180 190 200
PALLSSLVPP VVFLIMKESG YDLLACIVSS SLVLFDNAHV TEGRLILLDA
210 220 230 240 250
TLLFSMVCAI YCYVRFFKLR HTPFSRPWWA WLFFTGFFLS CTISTKYVGF
260 270 280 290 300
FTFLSIGLSV CLELWYLWDI KTGLTVERFF QHFLARFFCL IFFPFLFFLF
310 320 330 340 350
WFYMHFNILT ISGPGDSFMS LEFQETLSDN PITANSTILN YYDIVTIKHM
360 370 380 390 400
GTNAFLHSHP EKYPIPYDDG RISSGGQQVT GYQFDDENNY WMILPADHYD
410 420 430 440 450
PPIEAKLNVP VKNMDYIKLH HVGTNTDLMT HDVASPYHPT NEEFTTVSVD
460 470 480 490 500
ESAGKKHEYT LFQVVMSDNT DPQRPLYTKA SSFKLIHKLT HVAMWSDPKP
510 520 530 540 550
LPDWAFKQLE INGAKNIQTG SIFWTFDDII GLKDSRLKKE KKIPKKLPFW
560 570 580 590 600
KKYLELQLTM FRQNNMLTEF HPYSSNPSDW FTLHHGIAFW AKSEENKQIY
610 620 630 640 650
LLGNPIGWWI IAGTVLSTTV VAAAEILLRQ RGIRTLPETV RNHFYRSTMF
660 670 680 690 700
FYMTYVFHYL PFFIMGRQLF LHHYLPAHLA GSLLVGAFIQ LACRKSFRSP
710 720 730 740 750
VSAGVPIPKD VDEKGHSKCH RKYGHVIELI CTLLLIFVVI YCFTFFAPMT
760 770
YGDKSLSVDE WTRRKWLDSW VFQYQKQN
Length:778
Mass (Da):90,091
Last modified:June 1, 1998 - v1
Checksum:i7A0A79377D2AA8A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16916.1.
AB027986 Genomic DNA. Translation: BAA87290.1.
PIRiT39560.
RefSeqiNP_596807.1. NM_001023828.2.

Genome annotation databases

EnsemblFungiiSPBC16C6.09.1; SPBC16C6.09.1:pep; SPBC16C6.09.
GeneIDi2539761.
KEGGispo:SPBC16C6.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16916.1.
AB027986 Genomic DNA. Translation: BAA87290.1.
PIRiT39560.
RefSeqiNP_596807.1. NM_001023828.2.

3D structure databases

ProteinModelPortaliO42933.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276312. 2 interactors.
MINTiMINT-4674080.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

Proteomic databases

MaxQBiO42933.
PRIDEiO42933.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC16C6.09.1; SPBC16C6.09.1:pep; SPBC16C6.09.
GeneIDi2539761.
KEGGispo:SPBC16C6.09.

Organism-specific databases

EuPathDBiFungiDB:SPBC16C6.09.
PomBaseiSPBC16C6.09. ogm4.

Phylogenomic databases

HOGENOMiHOG000157526.
InParanoidiO42933.
KOiK00728.
OMAiFWTQNDT.
OrthoDBiEOG092C0JF4.
PhylomeDBiO42933.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.1.109. 5613.

Miscellaneous databases

PROiO42933.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39-like.
IPR003342. Glyco_trans_39/83.
IPR016093. MIR_motif.
IPR032421. PMT_4TMC.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 2 hits.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
PF16192. PMT_4TMC. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 2 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPMT4_SCHPO
AccessioniPrimary (citable) accession number: O42933
Secondary accession number(s): Q9US82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.