Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O42933

- PMT4_SCHPO

UniProt

O42933 - PMT4_SCHPO

Protein

Dolichyl-phosphate-mannose--protein mannosyltransferase 4

Gene

ogm4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Required for normal cell wall and septum formation.2 Publications

    Catalytic activityi

    Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

    Pathwayi

    GO - Molecular functioni

    1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall mannoprotein biosynthetic process Source: PomBase
    2. protein O-linked mannosylation Source: PomBase

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.109. 5615.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT39. Glycosyltransferase Family 39.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dolichyl-phosphate-mannose--protein mannosyltransferase 4 (EC:2.4.1.109)
    Gene namesi
    Name:ogm4
    Synonyms:oma4
    ORF Names:SPBC16C6.09
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC16C6.09.

    Subcellular locationi

    Endoplasmic reticulum membrane 3 Publications; Multi-pass membrane protein 3 Publications

    GO - Cellular componenti

    1. dolichyl-phosphate-mannose-protein mannosyltransferase complex Source: PomBase
    2. endomembrane system Source: PomBase
    3. endoplasmic reticulum Source: PomBase
    4. endoplasmic reticulum membrane Source: PomBase
    5. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 778778Dolichyl-phosphate-mannose--protein mannosyltransferase 4PRO_0000121500Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO42933.

    Interactioni

    Protein-protein interaction databases

    BioGridi276312. 1 interaction.
    MINTiMINT-4674080.
    STRINGi4896.SPBC16C6.09-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO42933.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei223 – 24321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei248 – 26821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei608 – 62821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei644 – 66421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei669 – 68921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei726 – 74621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini336 – 39661MIR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini408 – 46760MIR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini474 – 52956MIR 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyltransferase 39 family.Curated
    Contains 3 MIR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000157526.
    KOiK00728.
    OMAiHVPYVGM.
    OrthoDBiEOG7BP89X.
    PhylomeDBiO42933.

    Family and domain databases

    InterProiIPR027005. GlyclTrfase_39_like.
    IPR003342. Glyco_trans_39.
    IPR016093. MIR_motif.
    [Graphical view]
    PANTHERiPTHR10050. PTHR10050. 1 hit.
    PfamiPF02815. MIR. 1 hit.
    PF02366. PMT. 1 hit.
    [Graphical view]
    SMARTiSM00472. MIR. 2 hits.
    [Graphical view]
    SUPFAMiSSF82109. SSF82109. 1 hit.
    PROSITEiPS50919. MIR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42933-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKSEKAVK KAQKLSKEPS VELTDTKSSD NVTPKQKSPN STEEDVSLNL    50
    KTLKAKKFKL AFVLITVLSF ITRFWNLNLP GEVVFDEVHF GKFASYYLQG 100
    KYFFDLHPPF AKLLLALVAK LAGYDGHYLF DNIGDNYKDN GVPYVTIRAW 150
    PALLSSLVPP VVFLIMKESG YDLLACIVSS SLVLFDNAHV TEGRLILLDA 200
    TLLFSMVCAI YCYVRFFKLR HTPFSRPWWA WLFFTGFFLS CTISTKYVGF 250
    FTFLSIGLSV CLELWYLWDI KTGLTVERFF QHFLARFFCL IFFPFLFFLF 300
    WFYMHFNILT ISGPGDSFMS LEFQETLSDN PITANSTILN YYDIVTIKHM 350
    GTNAFLHSHP EKYPIPYDDG RISSGGQQVT GYQFDDENNY WMILPADHYD 400
    PPIEAKLNVP VKNMDYIKLH HVGTNTDLMT HDVASPYHPT NEEFTTVSVD 450
    ESAGKKHEYT LFQVVMSDNT DPQRPLYTKA SSFKLIHKLT HVAMWSDPKP 500
    LPDWAFKQLE INGAKNIQTG SIFWTFDDII GLKDSRLKKE KKIPKKLPFW 550
    KKYLELQLTM FRQNNMLTEF HPYSSNPSDW FTLHHGIAFW AKSEENKQIY 600
    LLGNPIGWWI IAGTVLSTTV VAAAEILLRQ RGIRTLPETV RNHFYRSTMF 650
    FYMTYVFHYL PFFIMGRQLF LHHYLPAHLA GSLLVGAFIQ LACRKSFRSP 700
    VSAGVPIPKD VDEKGHSKCH RKYGHVIELI CTLLLIFVVI YCFTFFAPMT 750
    YGDKSLSVDE WTRRKWLDSW VFQYQKQN 778
    Length:778
    Mass (Da):90,091
    Last modified:June 1, 1998 - v1
    Checksum:i7A0A79377D2AA8A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA16916.1.
    AB027986 Genomic DNA. Translation: BAA87290.1.
    PIRiT39560.
    RefSeqiNP_596807.1. NM_001023828.2.

    Genome annotation databases

    EnsemblFungiiSPBC16C6.09.1; SPBC16C6.09.1:pep; SPBC16C6.09.
    GeneIDi2539761.
    KEGGispo:SPBC16C6.09.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA16916.1 .
    AB027986 Genomic DNA. Translation: BAA87290.1 .
    PIRi T39560.
    RefSeqi NP_596807.1. NM_001023828.2.

    3D structure databases

    ProteinModelPortali O42933.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276312. 1 interaction.
    MINTi MINT-4674080.
    STRINGi 4896.SPBC16C6.09-1.

    Protein family/group databases

    CAZyi GT39. Glycosyltransferase Family 39.

    Proteomic databases

    MaxQBi O42933.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC16C6.09.1 ; SPBC16C6.09.1:pep ; SPBC16C6.09 .
    GeneIDi 2539761.
    KEGGi spo:SPBC16C6.09.

    Organism-specific databases

    PomBasei SPBC16C6.09.

    Phylogenomic databases

    HOGENOMi HOG000157526.
    KOi K00728.
    OMAi HVPYVGM.
    OrthoDBi EOG7BP89X.
    PhylomeDBi O42933.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BRENDAi 2.4.1.109. 5615.

    Miscellaneous databases

    NextBioi 20800911.
    PROi O42933.

    Family and domain databases

    InterProi IPR027005. GlyclTrfase_39_like.
    IPR003342. Glyco_trans_39.
    IPR016093. MIR_motif.
    [Graphical view ]
    PANTHERi PTHR10050. PTHR10050. 1 hit.
    Pfami PF02815. MIR. 1 hit.
    PF02366. PMT. 1 hit.
    [Graphical view ]
    SMARTi SM00472. MIR. 2 hits.
    [Graphical view ]
    SUPFAMi SSF82109. SSF82109. 1 hit.
    PROSITEi PS50919. MIR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
      Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
      Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-105, SUBCELLULAR LOCATION.
      Strain: ATCC 38364 / 968.
    3. "Characterization of O-mannosyltransferase family in Schizosaccharomyces pombe."
      Tanaka N., Fujita Y., Suzuki S., Morishita M., Giga-Hama Y., Shimoda C., Takegawa K.
      Biochem. Biophys. Res. Commun. 330:813-820(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. "Protein O-mannosylation is crucial for cell wall integrity, septation and viability in fission yeast."
      Willer T., Brandl M., Sipiczki M., Strahl S.
      Mol. Microbiol. 57:156-170(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPMT4_SCHPO
    AccessioniPrimary (citable) accession number: O42933
    Secondary accession number(s): Q9US82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3