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O42933

- PMT4_SCHPO

UniProt

O42933 - PMT4_SCHPO

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Protein

Dolichyl-phosphate-mannose--protein mannosyltransferase 4

Gene

ogm4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Required for normal cell wall and septum formation.2 Publications

Catalytic activityi

Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein.

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall mannoprotein biosynthetic process Source: PomBase
  2. protein O-linked mannosylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.109. 5615.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-phosphate-mannose--protein mannosyltransferase 4 (EC:2.4.1.109)
Gene namesi
Name:ogm4
Synonyms:oma4
ORF Names:SPBC16C6.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC16C6.09.

Subcellular locationi

Endoplasmic reticulum membrane 3 Publications; Multi-pass membrane protein 3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence AnalysisAdd
BLAST
Transmembranei248 – 26821HelicalSequence AnalysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence AnalysisAdd
BLAST
Transmembranei608 – 62821HelicalSequence AnalysisAdd
BLAST
Transmembranei644 – 66421HelicalSequence AnalysisAdd
BLAST
Transmembranei669 – 68921HelicalSequence AnalysisAdd
BLAST
Transmembranei726 – 74621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. dolichyl-phosphate-mannose-protein mannosyltransferase complex Source: PomBase
  2. endomembrane system Source: PomBase
  3. endoplasmic reticulum Source: PomBase
  4. endoplasmic reticulum membrane Source: PomBase
  5. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 778778Dolichyl-phosphate-mannose--protein mannosyltransferase 4PRO_0000121500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO42933.

Interactioni

Protein-protein interaction databases

BioGridi276312. 1 interaction.
MINTiMINT-4674080.
STRINGi4896.SPBC16C6.09-1.

Structurei

3D structure databases

ProteinModelPortaliO42933.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini336 – 39661MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini408 – 46760MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini474 – 52956MIR 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 39 family.Curated
Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000157526.
InParanoidiO42933.
KOiK00728.
OMAiHVPYVGM.
OrthoDBiEOG7BP89X.
PhylomeDBiO42933.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 2 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42933-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKSEKAVK KAQKLSKEPS VELTDTKSSD NVTPKQKSPN STEEDVSLNL
60 70 80 90 100
KTLKAKKFKL AFVLITVLSF ITRFWNLNLP GEVVFDEVHF GKFASYYLQG
110 120 130 140 150
KYFFDLHPPF AKLLLALVAK LAGYDGHYLF DNIGDNYKDN GVPYVTIRAW
160 170 180 190 200
PALLSSLVPP VVFLIMKESG YDLLACIVSS SLVLFDNAHV TEGRLILLDA
210 220 230 240 250
TLLFSMVCAI YCYVRFFKLR HTPFSRPWWA WLFFTGFFLS CTISTKYVGF
260 270 280 290 300
FTFLSIGLSV CLELWYLWDI KTGLTVERFF QHFLARFFCL IFFPFLFFLF
310 320 330 340 350
WFYMHFNILT ISGPGDSFMS LEFQETLSDN PITANSTILN YYDIVTIKHM
360 370 380 390 400
GTNAFLHSHP EKYPIPYDDG RISSGGQQVT GYQFDDENNY WMILPADHYD
410 420 430 440 450
PPIEAKLNVP VKNMDYIKLH HVGTNTDLMT HDVASPYHPT NEEFTTVSVD
460 470 480 490 500
ESAGKKHEYT LFQVVMSDNT DPQRPLYTKA SSFKLIHKLT HVAMWSDPKP
510 520 530 540 550
LPDWAFKQLE INGAKNIQTG SIFWTFDDII GLKDSRLKKE KKIPKKLPFW
560 570 580 590 600
KKYLELQLTM FRQNNMLTEF HPYSSNPSDW FTLHHGIAFW AKSEENKQIY
610 620 630 640 650
LLGNPIGWWI IAGTVLSTTV VAAAEILLRQ RGIRTLPETV RNHFYRSTMF
660 670 680 690 700
FYMTYVFHYL PFFIMGRQLF LHHYLPAHLA GSLLVGAFIQ LACRKSFRSP
710 720 730 740 750
VSAGVPIPKD VDEKGHSKCH RKYGHVIELI CTLLLIFVVI YCFTFFAPMT
760 770
YGDKSLSVDE WTRRKWLDSW VFQYQKQN
Length:778
Mass (Da):90,091
Last modified:June 1, 1998 - v1
Checksum:i7A0A79377D2AA8A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16916.1.
AB027986 Genomic DNA. Translation: BAA87290.1.
PIRiT39560.
RefSeqiNP_596807.1. NM_001023828.2.

Genome annotation databases

EnsemblFungiiSPBC16C6.09.1; SPBC16C6.09.1:pep; SPBC16C6.09.
GeneIDi2539761.
KEGGispo:SPBC16C6.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16916.1 .
AB027986 Genomic DNA. Translation: BAA87290.1 .
PIRi T39560.
RefSeqi NP_596807.1. NM_001023828.2.

3D structure databases

ProteinModelPortali O42933.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276312. 1 interaction.
MINTi MINT-4674080.
STRINGi 4896.SPBC16C6.09-1.

Protein family/group databases

CAZyi GT39. Glycosyltransferase Family 39.

Proteomic databases

MaxQBi O42933.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC16C6.09.1 ; SPBC16C6.09.1:pep ; SPBC16C6.09 .
GeneIDi 2539761.
KEGGi spo:SPBC16C6.09.

Organism-specific databases

PomBasei SPBC16C6.09.

Phylogenomic databases

HOGENOMi HOG000157526.
InParanoidi O42933.
KOi K00728.
OMAi HVPYVGM.
OrthoDBi EOG7BP89X.
PhylomeDBi O42933.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BRENDAi 2.4.1.109. 5615.

Miscellaneous databases

NextBioi 20800911.
PROi O42933.

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
Pfami PF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view ]
SMARTi SM00472. MIR. 2 hits.
[Graphical view ]
SUPFAMi SSF82109. SSF82109. 1 hit.
PROSITEi PS50919. MIR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-105, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.
  3. "Characterization of O-mannosyltransferase family in Schizosaccharomyces pombe."
    Tanaka N., Fujita Y., Suzuki S., Morishita M., Giga-Hama Y., Shimoda C., Takegawa K.
    Biochem. Biophys. Res. Commun. 330:813-820(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "Protein O-mannosylation is crucial for cell wall integrity, septation and viability in fission yeast."
    Willer T., Brandl M., Sipiczki M., Strahl S.
    Mol. Microbiol. 57:156-170(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPMT4_SCHPO
AccessioniPrimary (citable) accession number: O42933
Secondary accession number(s): Q9US82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3