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Protein

26S proteasome regulatory subunit 7 homolog

Gene

rpt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 227ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-6798695. Neutrophil degranulation.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit 7 homolog
Gene namesi
Name:rpt1
ORF Names:SPBC16C6.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16C6.07c.
PomBaseiSPBC16C6.07c. rpt1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847181 – 43826S proteasome regulatory subunit 7 homologAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO42931.
PRIDEiO42931.

PTM databases

iPTMnetiO42931.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276409. 12 interactors.
IntActiO42931. 1 interactor.
MINTiMINT-4674059.
STRINGi4896.SPBC16C6.07c.1.

Structurei

3D structure databases

ProteinModelPortaliO42931.
SMRiO42931.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

HOGENOMiHOG000225143.
InParanoidiO42931.
KOiK03061.
OMAiNKYQIHL.
OrthoDBiEOG092C19WS.
PhylomeDBiO42931.

Family and domain databases

InterProiView protein in InterPro
IPR005937. 26S_Psome_P45-like.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR035245. PSMC2.
PANTHERiPTHR23073:SF46. PTHR23073:SF46. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

O42931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKEDWEKY QKPVDTEEEN DKNPPPLDEG DIELLKSYAT GPYARELAAI
60 70 80 90 100
KEDTEAVLKR INDTVGIKES DTGLAPISFW DVAADRQRMS EEQPLQVARC
110 120 130 140 150
TKIIENEQSA EKNAYVINLK QIAKFVVSLG ERVSPTDIEE GMRVGCDRNK
160 170 180 190 200
YAIQLPLPPK IDPSVTMMQV EEKPDVTYGD VGGCKEQIER LREVVELPLL
210 220 230 240 250
SPERFVKLGI DPPKGIMLYG PPGTGKTLCA RAVANRTDAT FIRVIGSELV
260 270 280 290 300
QKYVGEGARM VRELFEMART KKACIIFFDE IDAIGGARFD DGAGGDNEVQ
310 320 330 340 350
RTMLELITQL DGFDPRGNIK VLFATNRPNT LDEALMRPGR IDRKVEFGLP
360 370 380 390 400
DLEGRAHILR IHAKSMAIDK DIRWELIARL CPSQTGAELR SVCTEAGMFA
410 420 430
IRARRRVATE KDFLDAVQKV VKGNQKFSST ADYMNMSS
Length:438
Mass (Da):48,965
Last modified:May 1, 2000 - v2
Checksum:iD1D5D24C926FC74D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16915.2.
PIRiT39558.
RefSeqiNP_596805.1. NM_001023826.2.

Genome annotation databases

EnsemblFungiiSPBC16C6.07c.1; SPBC16C6.07c.1:pep; SPBC16C6.07c.
GeneIDi2539862.
KEGGispo:SPBC16C6.07c.

Similar proteinsi

Entry informationi

Entry nameiPRS7_SCHPO
AccessioniPrimary (citable) accession number: O42931
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families