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Protein

26S protease regulatory subunit 7 homolog

Gene

rpt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi220 – 2278ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S protease regulatory subunit 7 homolog
Gene namesi
Name:rpt1
ORF Names:SPBC16C6.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16C6.07c.
PomBaseiSPBC16C6.07c. rpt1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • cytosolic proteasome complex Source: GO_Central
  • nuclear proteasome complex Source: GO_Central
  • nucleus Source: PomBase
  • proteasome regulatory particle, base subcomplex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 43843826S protease regulatory subunit 7 homologPRO_0000084718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO42931.
PRIDEiO42931.

PTM databases

iPTMnetiO42931.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276409. 12 interactions.
IntActiO42931. 1 interaction.
MINTiMINT-4674059.

Structurei

3D structure databases

ProteinModelPortaliO42931.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

HOGENOMiHOG000225143.
InParanoidiO42931.
KOiK03061.
OMAiARTNIFR.
OrthoDBiEOG7X3R1G.
PhylomeDBiO42931.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKEDWEKY QKPVDTEEEN DKNPPPLDEG DIELLKSYAT GPYARELAAI
60 70 80 90 100
KEDTEAVLKR INDTVGIKES DTGLAPISFW DVAADRQRMS EEQPLQVARC
110 120 130 140 150
TKIIENEQSA EKNAYVINLK QIAKFVVSLG ERVSPTDIEE GMRVGCDRNK
160 170 180 190 200
YAIQLPLPPK IDPSVTMMQV EEKPDVTYGD VGGCKEQIER LREVVELPLL
210 220 230 240 250
SPERFVKLGI DPPKGIMLYG PPGTGKTLCA RAVANRTDAT FIRVIGSELV
260 270 280 290 300
QKYVGEGARM VRELFEMART KKACIIFFDE IDAIGGARFD DGAGGDNEVQ
310 320 330 340 350
RTMLELITQL DGFDPRGNIK VLFATNRPNT LDEALMRPGR IDRKVEFGLP
360 370 380 390 400
DLEGRAHILR IHAKSMAIDK DIRWELIARL CPSQTGAELR SVCTEAGMFA
410 420 430
IRARRRVATE KDFLDAVQKV VKGNQKFSST ADYMNMSS
Length:438
Mass (Da):48,965
Last modified:May 1, 2000 - v2
Checksum:iD1D5D24C926FC74D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16915.2.
PIRiT39558.
RefSeqiNP_596805.1. NM_001023826.2.

Genome annotation databases

EnsemblFungiiSPBC16C6.07c.1; SPBC16C6.07c.1:pep; SPBC16C6.07c.
GeneIDi2539862.
KEGGispo:SPBC16C6.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16915.2.
PIRiT39558.
RefSeqiNP_596805.1. NM_001023826.2.

3D structure databases

ProteinModelPortaliO42931.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276409. 12 interactions.
IntActiO42931. 1 interaction.
MINTiMINT-4674059.

PTM databases

iPTMnetiO42931.

Proteomic databases

MaxQBiO42931.
PRIDEiO42931.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC16C6.07c.1; SPBC16C6.07c.1:pep; SPBC16C6.07c.
GeneIDi2539862.
KEGGispo:SPBC16C6.07c.

Organism-specific databases

EuPathDBiFungiDB:SPBC16C6.07c.
PomBaseiSPBC16C6.07c. rpt1.

Phylogenomic databases

HOGENOMiHOG000225143.
InParanoidiO42931.
KOiK03061.
OMAiARTNIFR.
OrthoDBiEOG7X3R1G.
PhylomeDBiO42931.

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiO42931.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPRS7_SCHPO
AccessioniPrimary (citable) accession number: O42931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.