Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-acetyltransferase eso1

Gene

eso1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. The relevance of acetyltransferase function remains unclear (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri653 – 677CCHH-typeAdd BLAST25

GO - Molecular functioni

  • damaged DNA binding Source: InterPro
  • DNA-directed DNA polymerase activity Source: PomBase
  • metal ion binding Source: UniProtKB-KW
  • peptidyl-lysine acetyltransferase activity Source: PomBase

GO - Biological processi

  • error-free translesion synthesis Source: PomBase
  • error-prone translesion synthesis Source: PomBase
  • establishment of mitotic sister chromatid cohesion Source: PomBase
  • peptidyl-lysine N6-acetylation Source: PomBase
  • positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric Source: PomBase
  • regulation of maintenance of mitotic sister chromatid cohesion Source: PomBase
  • translesion synthesis Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-110320. Translesion Synthesis by POLH.
R-SPO-5656169. Termination of translesion DNA synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyltransferase eso1 (EC:2.3.1.-)
Alternative name(s):
ECO1 homolog
Sister chromatid cohesion protein eso1
Gene namesi
Name:eso1
ORF Names:SPBC16A3.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16A3.11.
PomBaseiSPBC16A3.11. eso1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: PomBase
  • site of double-strand break Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001739941 – 872N-acetyltransferase eso1Add BLAST872

Proteomic databases

MaxQBiO42917.
PRIDEiO42917.

Interactioni

Subunit structurei

Interacts with pds5.1 Publication

Protein-protein interaction databases

BioGridi276221. 241 interactors.
IntActiO42917. 1 interactor.
MINTiMINT-4673961.

Structurei

3D structure databases

ProteinModelPortaliO42917.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 285UmuCPROSITE-ProRule annotationAdd BLAST257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 591Polymerase type-YAdd BLAST591
Regioni592 – 872AcetyltransferaseAdd BLAST281

Sequence similaritiesi

In the C-terminal section; belongs to the acetyltransferase family. ECO subfamily.Curated
In the N-terminal section; belongs to the DNA polymerase type-Y family.Curated
Contains 1 umuC domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri653 – 677CCHH-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiO42917.
KOiK03509.
OrthoDBiEOG092C18P5.
PhylomeDBiO42917.

Family and domain databases

Gene3Di3.30.1490.100. 1 hit.
InterProiIPR028005. AcTrfase_ESCO_Znf_dom.
IPR017961. DNA_pol_Y-fam_little_finger.
IPR028009. ESCO_Acetyltransf_dom.
IPR001126. UmuC.
[Graphical view]
PfamiPF13880. Acetyltransf_13. 1 hit.
PF00817. IMS. 1 hit.
PF11799. IMS_C. 1 hit.
PF13878. zf-C2H2_3. 1 hit.
[Graphical view]
SUPFAMiSSF100879. SSF100879. 1 hit.
PROSITEiPS50173. UMUC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGKSKFSW KDLQYCDKAG TQNSPLRVVA HIDQDAFYAQ VESVRLGLDH
60 70 80 90 100
SVPLAVQQWQ GLIAVNYAAR AANISRHETV TEAKKKCPEL CTAHVKTWKA
110 120 130 140 150
GESEAKYHEN PNPNYYKTCL DPYRHESVKI LNIIKKHAPV VKKASIDECF
160 170 180 190 200
IELTSDVKRI VLEEYPYLKI PSEDSNVALP QAPVLLWPAE FGMVIEEEVV
210 220 230 240 250
DRTKEDYERD WDDVFLFYAA KIVKEIRDDI YLQLKYTCSA GVSFNPMLSK
260 270 280 290 300
LVSSRNKPNK QTILTKNAIQ DYLVSLKITD IRMLGGKFGE EIINLLGTDS
310 320 330 340 350
IKDVWNMSMD FLIDKLGQTN GPLVWNLCHG IDNTEITTQV QIKSMLSAKN
360 370 380 390 400
FSQQKVKSEE DAINWFQVFA SDLRSRFLEL EGMRRPKTIC LTVVSRFLRK
410 420 430 440 450
SRSSQIPMNV DISTQFIVEA TSKLLRQLQQ EFDVYPISNL SISFQNIIEV
460 470 480 490 500
DRNSRGIEGF LKKSNDEIYM STSVSPSIEG RAKLLNENMR ENNSFELSSE
510 520 530 540 550
KDIKSPKRLK RGKGKGIFDM LQQTAVSKPT ENSADETYTC EECEQKITLS
560 570 580 590 600
ERNEHEDYHI ALSISRKERY NNLVPPSHDK PKQVKPKTYG RKTGSKHYAP
610 620 630 640 650
LSDETNNKRA FLDAFLGNGG NLTPNWKKQT PKAISNSSDN MTQLHLDLAN
660 670 680 690 700
STVTCSECSM EYNSTSEEDI LLHSRFHSRV LGGVTVSFQC SPIYRVNYGL
710 720 730 740 750
SSDCIYSINS ESSLIDQRKA EEALSFVNNE LSSEPIETIG VDKYTTFLFI
760 770 780 790 800
SDKKCVGLLL AERISSAYIV DELELNNNNS TSSAVYIKNE NLRKGFVLGI
810 820 830 840 850
SRIWVSASRR KQGIASLLLD NALKKFIYGY VISPAEVAFS QPSESGKQFI
860 870
ISWHRSRNNG SSKSLRYAVY ES
Length:872
Mass (Da):98,909
Last modified:June 1, 1998 - v1
Checksum:i36ECCD2BC0AEFE94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039861 mRNA. Translation: BAA95122.1.
CU329671 Genomic DNA. Translation: CAA16862.1.
PIRiT39541.
RefSeqiNP_596778.1. NM_001023799.2.

Genome annotation databases

EnsemblFungiiSPBC16A3.11.1; SPBC16A3.11.1:pep; SPBC16A3.11.
GeneIDi2539666.
KEGGispo:SPBC16A3.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039861 mRNA. Translation: BAA95122.1.
CU329671 Genomic DNA. Translation: CAA16862.1.
PIRiT39541.
RefSeqiNP_596778.1. NM_001023799.2.

3D structure databases

ProteinModelPortaliO42917.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276221. 241 interactors.
IntActiO42917. 1 interactor.
MINTiMINT-4673961.

Proteomic databases

MaxQBiO42917.
PRIDEiO42917.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC16A3.11.1; SPBC16A3.11.1:pep; SPBC16A3.11.
GeneIDi2539666.
KEGGispo:SPBC16A3.11.

Organism-specific databases

EuPathDBiFungiDB:SPBC16A3.11.
PomBaseiSPBC16A3.11. eso1.

Phylogenomic databases

InParanoidiO42917.
KOiK03509.
OrthoDBiEOG092C18P5.
PhylomeDBiO42917.

Enzyme and pathway databases

ReactomeiR-SPO-110320. Translesion Synthesis by POLH.
R-SPO-5656169. Termination of translesion DNA synthesis.

Miscellaneous databases

PROiO42917.

Family and domain databases

Gene3Di3.30.1490.100. 1 hit.
InterProiIPR028005. AcTrfase_ESCO_Znf_dom.
IPR017961. DNA_pol_Y-fam_little_finger.
IPR028009. ESCO_Acetyltransf_dom.
IPR001126. UmuC.
[Graphical view]
PfamiPF13880. Acetyltransf_13. 1 hit.
PF00817. IMS. 1 hit.
PF11799. IMS_C. 1 hit.
PF13878. zf-C2H2_3. 1 hit.
[Graphical view]
SUPFAMiSSF100879. SSF100879. 1 hit.
PROSITEiPS50173. UMUC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESO1_SCHPO
AccessioniPrimary (citable) accession number: O42917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.