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Protein

Serine/threonine-protein kinase ppk19

Gene

ppk19

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521ATPPROSITE-ProRule annotation
Active sitei146 – 1461Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 389ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-1632852. Macroautophagy.
R-SPO-1660514. Synthesis of PIPs at the Golgi membrane.
R-SPO-1660516. Synthesis of PIPs at the early endosome membrane.
R-SPO-1660517. Synthesis of PIPs at the late endosome membrane.
R-SPO-5668599. RHO GTPases Activate NADPH Oxidases.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ppk19 (EC:2.7.11.1)
Gene namesi
Name:ppk19
ORF Names:SPBC119.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC119.07.
PomBaseiSPBC119.07. ppk19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17061706Serine/threonine-protein kinase ppk19PRO_0000256820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei957 – 9571Phosphoserine1 Publication
Modified residuei958 – 9581Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO42900.

PTM databases

iPTMnetiO42900.

Interactioni

Protein-protein interaction databases

BioGridi276540. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO42900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 293270Protein kinasePROSITE-ProRule annotationAdd
BLAST
Repeati56 – 9439HEAT 1Add
BLAST
Repeati426 – 46540HEAT 2Add
BLAST
Repeati466 – 50439HEAT 3Add
BLAST
Repeati511 – 54939HEAT 4Add
BLAST
Repeati587 – 62539HEAT 5Add
BLAST
Repeati626 – 66439HEAT 6Add
BLAST
Repeati665 – 70339HEAT 7Add
BLAST
Repeati705 – 74339HEAT 8Add
BLAST
Repeati1213 – 125240WD 1Add
BLAST
Repeati1368 – 140740WD 2Add
BLAST
Repeati1577 – 162246WD 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1448 – 14558Poly-Ser

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 8 HEAT repeats.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 3 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiO42900.
KOiK08333.
OrthoDBiEOG77WWMQ.
PhylomeDBiO42900.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
2.130.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIQLSTIQT PQFHELFEEE LPEYHNERSL GDSHFLRTFR MQDRKGYDVL
60 70 80 90 100
IKVFVNKLPE ISLSSIVNLL KEEQENISYR VPNAVPYIKT LVTLRAAYLV
110 120 130 140 150
RPYVTHNLYD RISTRPFLEL TEKKWIMFQL LKGISDCHRL GVCHGDIKSE
160 170 180 190 200
NILITSWNWA YLSDFSSFKP TYLPEDNPAD YGYFFDTSSR RVCNIAPERF
210 220 230 240 250
VPASQLQPAP LSPAMDIFSL GCVFAELLLE ESPLFTLSQL FSYKAHGSYD
260 270 280 290 300
LQSVLEQIED KSTQNMILSM LDRDPSQRLS ADAYLQKYRG TVFPACFYDT
310 320 330 340 350
LYDYCIGLVD PSGILSAKQP NDACSLYGSR IDDIYRDIMP PNNNDISNLM
360 370 380 390 400
HTPHEYNGID SYSVPLFTTL DEFYNKNPAA KNWYLRLYNT MQEKKGFEDK
410 420 430 440 450
EQGSTPAPSP SVIEDISSIE TDENHLYGAA VLLPIVLSTI RHVNTRESKI
460 470 480 490 500
NALSLVQILS RNICDESKLD TVLPFVMTLL RDQYADVRIS ALITITRLVS
510 520 530 540 550
NVTSIAPINA FLFQEYLFPD LQHFLFDMNS RTRATYASCL PILAKQASKF
560 570 580 590 600
LNLAQSLRNA GILSFPESEY ENINHGKAEL LFETGRHDLV VTVERHVSTL
610 620 630 640 650
LADSSSIVRR SLLNALAPLC VFFGKAKSND LILSHLITYL NDTDWMLRCA
660 670 680 690 700
FFESITGLSI FIGPRSVDEY ILPLMLQALV DPEPAVLESV LGSFSGLIEL
710 720 730 740 750
HLFEKLVVVD ILQLVLPLVA VPNAYIRRAA LSVIYSAYQS FDDIDRDCIV
760 770 780 790 800
TPLLRPYLMS NLCDINSLEK LDQFILPMVS DSVWSTLTRW YEESENSSFW
810 820 830 840 850
KCDKDASYSS LDVSNDSLLG RTKNLQKREI MHHAEVYTHK KISLTGHVII
860 870 880 890 900
TSTEMLELSE DDQKWADIIK EMGVDVKHLW VLANLRDYVK KTKINLNGIN
910 920 930 940 950
YKRQSGLREL NTYPNAPLHI LPETIFWNPE RPPSSSIANE TFLDRNSYAE
960 970 980 990 1000
SIQTSRSYND DLIARDPIAY VGTDMTNAFG TTTKPKDVSQ SDIKVDINRE
1010 1020 1030 1040 1050
SNSDNGETIT GTHDVYRQTD NPEIKLPSDT ASSKVDTHNP TVTQPTDDTG
1060 1070 1080 1090 1100
GLNSYNTENP LLTNNTLEPS SVEAIVSSKD SDKHAKESKG KSLAPLISSR
1110 1120 1130 1140 1150
VSTNDTTNVA GIRSQRSFTT HIDLKKLTTR QNGAKKSSYT GTNPCVLNYL
1160 1170 1180 1190 1200
NKIYAEAAAS TLNVGAAVSP SWASNIPLRR RTKVSAKAAN KIVQTHEWHP
1210 1220 1230 1240 1250
EGSRVAQIYL GSLLDGGTKK VLVSPDSSFF VTLGSDGVVR AWQLVESVRH
1260 1270 1280 1290 1300
ISTMRCECRL SYGHTRRNGE RNRFSVVNGC FLGNTYAFAS VTQDGSVEVH
1310 1320 1330 1340 1350
RLDVNNQRHT LISAGRIPNL DFSDSVTSME ASTFHDGSIR LVVVTKWSRI
1360 1370 1380 1390 1400
VYLDVGMMRV LSSDQLPLQC GSATSVVVSE GCNWALIGTT KGWLLLWDLR
1410 1420 1430 1440 1450
FGTLSCSWHM PARIDQMHLL LDVTKKRSNV NEYTSGNNNS PVTKVPGSSS
1460 1470 1480 1490 1500
TSSSSTQPIN STIPINPLEN HGMLNSFGST TVSISFSVLT NLDNKEVNLE
1510 1520 1530 1540 1550
DAVPASHRSA SGIVNFDVEK GKTEEVFLEN WNSSLTSPIP VSVGIDAFNE
1560 1570 1580 1590 1600
KKKFDIDSGN DMGLRDLNTK FDSPWPCISS PIYRYRGPSA GSVEREPLFL
1610 1620 1630 1640 1650
IAASGSPHAF IWNPHNVSAS SSVTNDSESS KLSLIHNKPP IYQKVSEQQN
1660 1670 1680 1690 1700
VRPKSSGVSR PLLFLQQQKN LPSENRLHPI VDMAFLYQPY AIVLIVDAFG

SLELWT
Length:1,706
Mass (Da):191,094
Last modified:June 1, 1998 - v1
Checksum:iBFB1676379C74634
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA17922.1.
PIRiT39305.
RefSeqiNP_595288.1. NM_001021195.2.

Genome annotation databases

EnsemblFungiiSPBC119.07.1; SPBC119.07.1:pep; SPBC119.07.
GeneIDi2539996.
KEGGispo:SPBC119.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA17922.1.
PIRiT39305.
RefSeqiNP_595288.1. NM_001021195.2.

3D structure databases

ProteinModelPortaliO42900.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276540. 2 interactions.

PTM databases

iPTMnetiO42900.

Proteomic databases

MaxQBiO42900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC119.07.1; SPBC119.07.1:pep; SPBC119.07.
GeneIDi2539996.
KEGGispo:SPBC119.07.

Organism-specific databases

EuPathDBiFungiDB:SPBC119.07.
PomBaseiSPBC119.07. ppk19.

Phylogenomic databases

InParanoidiO42900.
KOiK08333.
OrthoDBiEOG77WWMQ.
PhylomeDBiO42900.

Enzyme and pathway databases

ReactomeiR-SPO-1632852. Macroautophagy.
R-SPO-1660514. Synthesis of PIPs at the Golgi membrane.
R-SPO-1660516. Synthesis of PIPs at the early endosome membrane.
R-SPO-1660517. Synthesis of PIPs at the late endosome membrane.
R-SPO-5668599. RHO GTPases Activate NADPH Oxidases.

Miscellaneous databases

PROiO42900.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
2.130.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Cited for: IDENTIFICATION.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-957 AND TYR-958, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPPK19_SCHPO
AccessioniPrimary (citable) accession number: O42900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.