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Protein

Probable catechol O-methyltransferase 1

Gene

SPBC119.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei78S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei86S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei106S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei107S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei135S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi162MagnesiumBy similarity1
Binding sitei162S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei165SubstrateBy similarity1
Metal bindingi190MagnesiumBy similarity1
Metal bindingi191MagnesiumBy similarity1
Binding sitei191SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCatecholamine metabolism
LigandMagnesium, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-SPO-156581 Methylation
R-SPO-379397 Enzymatic degradation of dopamine by COMT
R-SPO-379398 Enzymatic degradation of Dopamine by monoamine oxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable catechol O-methyltransferase 1 (EC:2.1.1.6)
Gene namesi
ORF Names:SPBC119.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC119.03
PomBaseiSPBC119.03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003181481 – 266Probable catechol O-methyltransferase 1Add BLAST266

Proteomic databases

MaxQBiO42898
PaxDbiO42898
PRIDEiO42898

PTM databases

iPTMnetiO42898

Interactioni

Protein-protein interaction databases

BioGridi2766121 interactor.
STRINGi4896.SPBC119.03.1

Structurei

3D structure databases

ProteinModelPortaliO42898
SMRiO42898
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000171638
InParanoidiO42898
KOiK00545
OMAiIDAYSHT
OrthoDBiEOG092C4KCD
PhylomeDBiO42898

Family and domain databases

InterProiView protein in InterPro
IPR002935 O-MeTrfase_3
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01596 Methyltransf_3, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51682 SAM_OMT_I, 1 hit

Sequencei

Sequence statusi: Complete.

O42898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHMEDNGSE KEQLFLQHIQ NLPQERLDAI RGHPELVLKE IDEFTYPDGS
60 70 80 90 100
GVRMCIGDVK GGFIVGKIRE RKPKIMVELG GYLGYSAILF GNEISKIPGG
110 120 130 140 150
RYYSLEVNED YAKIAYELVK LAGLDEIVTI MIGKACDSLV ELQQKLLHKD
160 170 180 190 200
LGFQALDMVF IDHWKDLYVP DLRVIESLNM IAPGTLLVAD NIITPGAPEY
210 220 230 240 250
HKYVNMSPEE RRGYQAKVRN VNGFDFIGRW DLIYKTETKE FEGVIRNKHR
260
KDAVDVTECV GYAKKD
Length:266
Mass (Da):30,267
Last modified:June 1, 1998 - v1
Checksum:i99316BCF4FAED5EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA17918.1
PIRiT39301
RefSeqiNP_595284.1, NM_001021191.2

Genome annotation databases

EnsemblFungiiSPBC119.03.1; SPBC119.03.1:pep; SPBC119.03
GeneIDi2540074
KEGGispo:SPBC119.03

Entry informationi

Entry nameiCOMT1_SCHPO
AccessioniPrimary (citable) accession number: O42898
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome