UniProtKB - O42898 (COMT1_SCHPO)
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Protein
Probable catechol O-methyltransferase 1
Gene
SPBC119.03
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Catalytic activityi
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
Cofactori
Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 56 | S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation | 1 | |
Binding sitei | 78 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 86 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 106 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 107 | S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation | 1 | |
Binding sitei | 135 | S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 162 | MagnesiumBy similarity | 1 | |
Binding sitei | 162 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 165 | SubstrateBy similarity | 1 | |
Metal bindingi | 190 | MagnesiumBy similarity | 1 | |
Metal bindingi | 191 | MagnesiumBy similarity | 1 | |
Binding sitei | 191 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- O-methyltransferase activity Source: PomBase
GO - Biological processi
- catecholamine metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Catecholamine metabolism |
Ligand | Magnesium, Metal-binding, S-adenosyl-L-methionine |
Enzyme and pathway databases
Reactomei | R-SPO-156581 Methylation R-SPO-379397 Enzymatic degradation of dopamine by COMT R-SPO-379398 Enzymatic degradation of Dopamine by monoamine oxidase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:SPBC119.03 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPBC119.03 |
PomBasei | SPBC119.03 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318148 | 1 – 266 | Probable catechol O-methyltransferase 1Add BLAST | 266 |
Proteomic databases
MaxQBi | O42898 |
PaxDbi | O42898 |
PRIDEi | O42898 |
PTM databases
iPTMneti | O42898 |
Interactioni
Protein-protein interaction databases
BioGridi | 2766121 interactor. |
STRINGi | 4896.SPBC119.03.1 |
Structurei
3D structure databases
ProteinModelPortali | O42898 |
SMRi | O42898 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation
Phylogenomic databases
HOGENOMi | HOG000171638 |
InParanoidi | O42898 |
KOi | K00545 |
OMAi | IDAYSHT |
OrthoDBi | EOG092C4KCD |
PhylomeDBi | O42898 |
Family and domain databases
InterProi | View protein in InterPro IPR002935 O-MeTrfase_3 IPR029063 SAM-dependent_MTases |
Pfami | View protein in Pfam PF01596 Methyltransf_3, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51682 SAM_OMT_I, 1 hit |
i Sequence
Sequence statusi: Complete.
O42898-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPHMEDNGSE KEQLFLQHIQ NLPQERLDAI RGHPELVLKE IDEFTYPDGS
60 70 80 90 100
GVRMCIGDVK GGFIVGKIRE RKPKIMVELG GYLGYSAILF GNEISKIPGG
110 120 130 140 150
RYYSLEVNED YAKIAYELVK LAGLDEIVTI MIGKACDSLV ELQQKLLHKD
160 170 180 190 200
LGFQALDMVF IDHWKDLYVP DLRVIESLNM IAPGTLLVAD NIITPGAPEY
210 220 230 240 250
HKYVNMSPEE RRGYQAKVRN VNGFDFIGRW DLIYKTETKE FEGVIRNKHR
260
KDAVDVTECV GYAKKD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAA17918.1 |
PIRi | T39301 |
RefSeqi | NP_595284.1, NM_001021191.2 |
Genome annotation databases
EnsemblFungii | SPBC119.03.1; SPBC119.03.1:pep; SPBC119.03 |
GeneIDi | 2540074 |
KEGGi | spo:SPBC119.03 |
Similar proteinsi
Entry informationi
Entry namei | COMT1_SCHPO | |
Accessioni | O42898Primary (citable) accession number: O42898 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | June 1, 1998 | |
Last modified: | March 28, 2018 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |