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O42898

- COMT1_SCHPO

UniProt

O42898 - COMT1_SCHPO

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Protein
Probable catechol O-methyltransferase 1
Gene
SPBC119.03
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.

Cofactori

Binds 1 magnesium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei78 – 781S-adenosyl-L-methionine By similarity
Binding sitei86 – 861S-adenosyl-L-methionine By similarity
Binding sitei106 – 1061S-adenosyl-L-methionine By similarity
Binding sitei107 – 1071S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei135 – 1351S-adenosyl-L-methionine; via amide nitrogen By similarity
Metal bindingi162 – 1621Magnesium By similarity
Binding sitei162 – 1621S-adenosyl-L-methionine By similarity
Binding sitei165 – 1651Substrate By similarity
Metal bindingi190 – 1901Magnesium By similarity
Metal bindingi191 – 1911Magnesium By similarity
Binding sitei191 – 1911Substrate By similarity

GO - Molecular functioni

  1. catechol O-methyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. catecholamine metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Catecholamine metabolism

Keywords - Ligandi

Magnesium, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable catechol O-methyltransferase 1 (EC:2.1.1.6)
Gene namesi
ORF Names:SPBC119.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC119.03.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Probable catechol O-methyltransferase 1
PRO_0000318148Add
BLAST

Proteomic databases

MaxQBiO42898.
PaxDbiO42898.

Interactioni

Protein-protein interaction databases

MINTiMINT-4673835.
STRINGi4896.SPBC119.03-1.

Structurei

3D structure databases

ProteinModelPortaliO42898.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4122.
HOGENOMiHOG000171638.
OMAiNIITPGA.
OrthoDBiEOG7KM644.
PhylomeDBiO42898.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025782. Catechol_O-MeTrfase.
IPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10509. PTHR10509. 1 hit.
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42898-1 [UniParc]FASTAAdd to Basket

« Hide

MPHMEDNGSE KEQLFLQHIQ NLPQERLDAI RGHPELVLKE IDEFTYPDGS    50
GVRMCIGDVK GGFIVGKIRE RKPKIMVELG GYLGYSAILF GNEISKIPGG 100
RYYSLEVNED YAKIAYELVK LAGLDEIVTI MIGKACDSLV ELQQKLLHKD 150
LGFQALDMVF IDHWKDLYVP DLRVIESLNM IAPGTLLVAD NIITPGAPEY 200
HKYVNMSPEE RRGYQAKVRN VNGFDFIGRW DLIYKTETKE FEGVIRNKHR 250
KDAVDVTECV GYAKKD 266
Length:266
Mass (Da):30,267
Last modified:June 1, 1998 - v1
Checksum:i99316BCF4FAED5EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA17918.1.
PIRiT39301.
RefSeqiNP_595284.1. NM_001021191.2.

Genome annotation databases

EnsemblFungiiSPBC119.03.1; SPBC119.03.1:pep; SPBC119.03.
GeneIDi2540074.
KEGGispo:SPBC119.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA17918.1 .
PIRi T39301.
RefSeqi NP_595284.1. NM_001021191.2.

3D structure databases

ProteinModelPortali O42898.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4673835.
STRINGi 4896.SPBC119.03-1.

Proteomic databases

MaxQBi O42898.
PaxDbi O42898.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC119.03.1 ; SPBC119.03.1:pep ; SPBC119.03 .
GeneIDi 2540074.
KEGGi spo:SPBC119.03.

Organism-specific databases

PomBasei SPBC119.03.

Phylogenomic databases

eggNOGi COG4122.
HOGENOMi HOG000171638.
OMAi NIITPGA.
OrthoDBi EOG7KM644.
PhylomeDBi O42898.

Miscellaneous databases

NextBioi 20801211.
PROi O42898.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025782. Catechol_O-MeTrfase.
IPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10509. PTHR10509. 1 hit.
Pfami PF01596. Methyltransf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51682. SAM_OMT_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOMT1_SCHPO
AccessioniPrimary (citable) accession number: O42898
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3