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O42898

- COMT1_SCHPO

UniProt

O42898 - COMT1_SCHPO

Protein

Probable catechol O-methyltransferase 1

Gene

SPBC119.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
    Binding sitei78 – 781S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei86 – 861S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei106 – 1061S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei107 – 1071S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
    Binding sitei135 – 1351S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
    Metal bindingi162 – 1621MagnesiumBy similarity
    Binding sitei162 – 1621S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei165 – 1651SubstrateBy similarity
    Metal bindingi190 – 1901MagnesiumBy similarity
    Metal bindingi191 – 1911MagnesiumBy similarity
    Binding sitei191 – 1911SubstrateBy similarity

    GO - Molecular functioni

    1. catechol O-methyltransferase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. catecholamine metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Catecholamine metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable catechol O-methyltransferase 1 (EC:2.1.1.6)
    Gene namesi
    ORF Names:SPBC119.03
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC119.03.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Probable catechol O-methyltransferase 1PRO_0000318148Add
    BLAST

    Proteomic databases

    MaxQBiO42898.
    PaxDbiO42898.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4673835.
    STRINGi4896.SPBC119.03-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO42898.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG4122.
    HOGENOMiHOG000171638.
    OMAiNIITPGA.
    OrthoDBiEOG7KM644.
    PhylomeDBiO42898.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025782. Catechol_O-MeTrfase.
    IPR002935. O-MeTrfase_3.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10509. PTHR10509. 1 hit.
    PfamiPF01596. Methyltransf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51682. SAM_OMT_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42898-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPHMEDNGSE KEQLFLQHIQ NLPQERLDAI RGHPELVLKE IDEFTYPDGS    50
    GVRMCIGDVK GGFIVGKIRE RKPKIMVELG GYLGYSAILF GNEISKIPGG 100
    RYYSLEVNED YAKIAYELVK LAGLDEIVTI MIGKACDSLV ELQQKLLHKD 150
    LGFQALDMVF IDHWKDLYVP DLRVIESLNM IAPGTLLVAD NIITPGAPEY 200
    HKYVNMSPEE RRGYQAKVRN VNGFDFIGRW DLIYKTETKE FEGVIRNKHR 250
    KDAVDVTECV GYAKKD 266
    Length:266
    Mass (Da):30,267
    Last modified:June 1, 1998 - v1
    Checksum:i99316BCF4FAED5EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA17918.1.
    PIRiT39301.
    RefSeqiNP_595284.1. NM_001021191.2.

    Genome annotation databases

    EnsemblFungiiSPBC119.03.1; SPBC119.03.1:pep; SPBC119.03.
    GeneIDi2540074.
    KEGGispo:SPBC119.03.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA17918.1 .
    PIRi T39301.
    RefSeqi NP_595284.1. NM_001021191.2.

    3D structure databases

    ProteinModelPortali O42898.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4673835.
    STRINGi 4896.SPBC119.03-1.

    Proteomic databases

    MaxQBi O42898.
    PaxDbi O42898.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC119.03.1 ; SPBC119.03.1:pep ; SPBC119.03 .
    GeneIDi 2540074.
    KEGGi spo:SPBC119.03.

    Organism-specific databases

    PomBasei SPBC119.03.

    Phylogenomic databases

    eggNOGi COG4122.
    HOGENOMi HOG000171638.
    OMAi NIITPGA.
    OrthoDBi EOG7KM644.
    PhylomeDBi O42898.

    Miscellaneous databases

    NextBioi 20801211.
    PROi O42898.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025782. Catechol_O-MeTrfase.
    IPR002935. O-MeTrfase_3.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10509. PTHR10509. 1 hit.
    Pfami PF01596. Methyltransf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51682. SAM_OMT_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOMT1_SCHPO
    AccessioniPrimary (citable) accession number: O42898
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3