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Protein

Neutral trehalase

Gene

ntp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei283SubstrateBy similarity1
Binding sitei327SubstrateBy similarity1
Binding sitei336SubstrateBy similarity1
Binding sitei455Substrate; via carbonyl oxygenBy similarity1
Active sitei457Proton donor/acceptorBy similarity1
Active sitei652Proton donor/acceptorBy similarity1

GO - Molecular functioni

  • alpha,alpha-trehalase activity Source: PomBase
  • calcium ion binding Source: PomBase

GO - Biological processi

  • ascospore formation Source: PomBase
  • trehalose catabolic process Source: PomBase
  • trehalose catabolic process involved in cellular response to stress Source: PomBase

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH37 Glycoside Hydrolase Family 37

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral trehalase (EC:3.2.1.28)
Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase
Gene namesi
Name:ntp1
ORF Names:SPBC660.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC660.07
PomBaseiSPBC660.07 ntp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737971 – 735Neutral trehalaseAdd BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Phosphothreonine1 Publication1
Modified residuei49Phosphoserine1 Publication1
Modified residuei50Phosphothreonine1 Publication1
Modified residuei51Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO42893
PaxDbiO42893
PRIDEiO42893

PTM databases

iPTMnetiO42893

Interactioni

Protein-protein interaction databases

BioGridi277630, 33 interactors
STRINGi4896.SPBC660.07.1

Structurei

3D structure databases

ProteinModelPortaliO42893
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni290 – 291Substrate bindingBy similarity2
Regioni336 – 338Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the glycosyl hydrolase 37 family.Curated

Phylogenomic databases

HOGENOMiHOG000192885
InParanoidiO42893
KOiK01194
OMAiMMTTAFV
OrthoDBiEOG092C0UDQ
PhylomeDBiO42893

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR001661 Glyco_hydro_37
IPR018232 Glyco_hydro_37_CS
IPR011120 Trehalase_Ca-bd
PANTHERiPTHR23403 PTHR23403, 1 hit
PfamiView protein in Pfam
PF01204 Trehalase, 1 hit
PF07492 Trehalase_Ca-bi, 1 hit
PRINTSiPR00744 GLHYDRLASE37
SUPFAMiSSF48208 SSF48208, 1 hit
PROSITEiView protein in PROSITE
PS00927 TREHALASE_1, 1 hit
PS00928 TREHALASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

O42893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKFSSKYV DTEAISNDDD NPFATAKSYY SKDTDLSTRV SAGRPRTLST
60 70 80 90 100
SMEASAAPTI PELKNLRRRG SLDEHKQPRK FLVDVDKTLN ALLESEDTDR
110 120 130 140 150
NMQITIEDTG PKVVSLGSAS SGGYRLYELR GTYQLSNLLQ ELTLAKDYGR
160 170 180 190 200
RYILLDERRL NENPVNRLSR LIKGTFWDAL TRRIDASVLD VICRDTKDRS
210 220 230 240 250
GSHVNRIYVP KAEQEMYEYY VRAAKERPYL NLQVEYLPEE ITPEWVRDVN
260 270 280 290 300
DKPGLLALAM EKYQDDEGNT HLRGVPFVVP GGRFNELYGW DSYFESLGLL
310 320 330 340 350
VDDRVDLAKG MVENFIFEIT YYGKILNANR TYYLLRSQPP FLTDMALRVY
360 370 380 390 400
ERIKNEEGSL DFLHRAFSAT IKEYHTVWTA TPRLDPKTGL SRYRPGGLGI
410 420 430 440 450
PPETEASHFE HLLRPYMEKY HMTLEEFTHA YNYQQIHEPA LDEYFVHDRA
460 470 480 490 500
VRESGHDTTY RLEKVCADLA TVDLNSLLYK YETDISHVIL EYFDDKFVLP
510 520 530 540 550
NGTIETSAIW DRRARARRAA MEKYLWSEAD SMWYDYNTKL ETKSTYESAT
560 570 580 590 600
AFWALWAGVA TPRQAAKFVD VSLPKFEVAG GIVAGTKRSL GKVGLDNPSR
610 620 630 640 650
QWDYPNGWSP QQILAWYGLI RYGYEEETRR LVYRWLYTIT KSFVDFNGIV
660 670 680 690 700
VEKYDLTRPV DPHRVEAEYG NQGVNIKGVA REGFGWVNAS YEVGLTFCNS
710 720 730
HMRRALGACT TPDVFFAGIK EESLPAFENL SIHKN
Length:735
Mass (Da):84,603
Last modified:June 1, 1998 - v1
Checksum:i73FF979534E91BD4
GO

Sequence cautioni

The sequence BAA13934 differs from that shown. Reason: Frameshift at positions 556 and 643.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224339 Genomic DNA Translation: CAA11904.1
CU329671 Genomic DNA Translation: CAA22527.1
AB027837 Genomic DNA Translation: BAA87141.1
D89273 mRNA Translation: BAA13934.1 Frameshift.
PIRiT40619
T43203
RefSeqiNP_595086.1, NM_001020993.2

Genome annotation databases

EnsemblFungiiSPBC660.07.1; SPBC660.07.1:pep; SPBC660.07
GeneIDi2541115
KEGGispo:SPBC660.07

Similar proteinsi

Entry informationi

Entry nameiTREA_SCHPO
AccessioniPrimary (citable) accession number: O42893
Secondary accession number(s): P78922, Q9UU37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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