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Reviewed, UniProtKB/Swiss-Prot O42890 (AMOH1_SCHPO)

Last modified January 19, 2010. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Putative primary amine oxidase 1
    EC=1.4.3.21
Alternative name(s):
    Copper amine oxidase 1
Gene names
ORF Names: SPBC1289.16c, SPBC8E4.06
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

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Protein attributes

Sequence length794 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2.

Cofactor

Binds 1 copper ion per subunit By similarity.

Contains 1 topaquinone per subunit By similarity.

Post-translational modification

Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue By similarity.

Sequence similarities

Belongs to the copper/topaquinone oxidase family.

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Ontologies

Keywords
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   PTMTPQ
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processamine metabolic process

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytosol

Inferred from direct assay. Source: GeneDB_SPombe

   Molecular functionamine oxidase activity

Inferred from electronic annotation. Source: EC

copper ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

quinone binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 794794Putative primary amine oxidase 1
PRO_0000064107

Sites

Active site3091Proton acceptor By similarity
Active site3941Schiff-base intermediate with substrate; via topaquinone By similarity
Metal binding4451Copper By similarity
Metal binding4471Copper By similarity
Metal binding6041Copper By similarity

Amino acid modifications

Modified residue39412',4',5'-topaquinone By similarity

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Sequences

Sequence LengthMass (Da)Tools
O42890-1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 81E0E1CAD73F54F9

FASTA79490,127
        10         20         30         40         50         60 
MAEESKAAEY FDPLDPLSFN ELRYVVNLVR KSYPEKQISF DVVTLSEPHK EEYVHWRYSS 

        70         80         90        100        110        120 
AHEGIPDRRA YVIVLEKEVP GVFEGIVNLT TGKIEKWEHS VDTCPIITAD LLAITDEIVR 

       130        140        150        160        170        180 
NDANVIEQCK ICGVPESGLS NVYCDPWTIG YDERYGSGRR LQQALMYYKP GDSGHLRSIP 

       190        200        210        220        230        240 
LDFCPIIDVD QKKVIAIDIP KVRRPIPQDV NSDNNLKKLE QEMEAMKMLK PLRITQPEGV 

       250        260        270        280        290        300 
NFRIKGRYIE WQNFCFHIGF NYREGIVLSD VVFNEDGHLR PLFYRISLTE MAVPFGAKGH 

       310        320        330        340        350        360 
SHHRKHAYDL GEYGVGYRTN PLSFTCGCEG VIHYMDADFV NYRGEITTIK NAISIHEEDD 

       370        380        390        400        410        420 
GVLFKYSDLR DRNANISARS IKLVVSQVFT AANYEYLVYW IFRMDGVIEC EIRLTGILNT 

       430        440        450        460        470        480 
NAINEDEDLK GHGTQVYPKI SAENHEHLFC LRINPMLDGL RNSVATVDAL RDKNGTLVSK 

       490        500        510        520        530        540 
YIIPETVTEA ISNYDSSTGR TWDICNLNKL HPYSGKPVSY KLISRDTSPV LSQPGTTNSD 

       550        560        570        580        590        600 
CSGFAENNIY VTPYMDDQIF PTGDYAPQAS DDTPKGLSKW ISDDPNAQIK NTDIVVWHTF 

       610        620        630        640        650        660 
GMIHFPAPED FPIMPAESIH LFLQPRNFFK HNPALDTSSS VNSTSEATSP NTHHENLRDT 

       670        680        690        700        710        720 
SQKRESHSTP HDYEPHVSDK NDKSVEDKLH FVQKDESRPK EPVVDAAQKH EGRSETLAQP 

       730        740        750        760        770        780 
GQQNANQSEE KQGGQNGSNG GHHHHHHHHY ITGHVYGGYH KHSGSGGHLV DMMKNISDVT 

       790 
HDFAMGNFRY HKYD

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References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329671 Genomic DNA. Translation: CAB38696.1.
PIRT39367.
T39171. T50376.
RefSeqNP_596841.2.

3D structure databases

SMRO42890. Positions 11-647.
ModBaseSearch...

Protein-protein interaction databases

STRINGO42890.

Genome annotation databases

GeneID2539624.
KEGGspo:SPBC1289.16c.

Organism-specific databases

GeneDB_SpombeSPBC1289.16c.

Phylogenomic databases

eggNOGfuNOG06311.
HOGENOMHBG325455.
OrthoDBEOG9MGTQT.
PhylomeDBO42890.

Enzyme and pathway databases

BRENDA1.4.3.6. 653.

Gene expression databases

ArrayExpressO42890.

Family and domain databases

InterProIPR000269. Cu_amine_oxidase.
IPR015798. Cu_amine_oxidase_C.
IPR016182. Cu_amine_oxidase_N-reg.
IPR015800. Cu_amine_oxidase_N2.
IPR015801. Cu_amine_oxidase_N2/3.
IPR015802. Cu_amine_oxidase_N3.
[Graphical view]
Gene3DG3DSA:3.10.450.40. CuNH_oxidase. 2 hits.
G3DSA:2.70.98.20. Lyase_8_central. 1 hit.
PANTHERPTHR10638. CuNH_oxidase. 1 hit.
PfamPF01179. Cu_amine_oxid. 1 hit.
PF02727. Cu_amine_oxidN2. 1 hit.
PF02728. Cu_amine_oxidN3. 1 hit.
[Graphical view]
PROSITEPS01164. COPPER_AMINE_OXID_1. 1 hit.
PS01165. COPPER_AMINE_OXID_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameAMOH1_SCHPO
AccessionPrimary (citable) accession number: O42890
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 1998
Last modified: January 19, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents