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O42890 (AMOH1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative primary amine oxidase 1
EC=1.4.3.21
Alternative name(s):
Copper amine oxidase 1
Gene names
ORF Names:SPBC1289.16c, SPBC8E4.06
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length794 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2.

Cofactor

Binds 1 copper ion per subunit By similarity.

Contains 1 topaquinone per subunit By similarity.

Post-translational modification

Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue By similarity.

Sequence similarities

Belongs to the copper/topaquinone oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 794794Putative primary amine oxidase 1
PRO_0000064107

Sites

Active site3091Proton acceptor By similarity
Active site3941Schiff-base intermediate with substrate; via topaquinone By similarity
Metal binding4451Copper By similarity
Metal binding4471Copper By similarity
Metal binding6041Copper By similarity

Amino acid modifications

Modified residue39412',4',5'-topaquinone By similarity

Sequences

Sequence LengthMass (Da)Tools
O42890 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 81E0E1CAD73F54F9

FASTA79490,127
        10         20         30         40         50         60 
MAEESKAAEY FDPLDPLSFN ELRYVVNLVR KSYPEKQISF DVVTLSEPHK EEYVHWRYSS 

        70         80         90        100        110        120 
AHEGIPDRRA YVIVLEKEVP GVFEGIVNLT TGKIEKWEHS VDTCPIITAD LLAITDEIVR 

       130        140        150        160        170        180 
NDANVIEQCK ICGVPESGLS NVYCDPWTIG YDERYGSGRR LQQALMYYKP GDSGHLRSIP 

       190        200        210        220        230        240 
LDFCPIIDVD QKKVIAIDIP KVRRPIPQDV NSDNNLKKLE QEMEAMKMLK PLRITQPEGV 

       250        260        270        280        290        300 
NFRIKGRYIE WQNFCFHIGF NYREGIVLSD VVFNEDGHLR PLFYRISLTE MAVPFGAKGH 

       310        320        330        340        350        360 
SHHRKHAYDL GEYGVGYRTN PLSFTCGCEG VIHYMDADFV NYRGEITTIK NAISIHEEDD 

       370        380        390        400        410        420 
GVLFKYSDLR DRNANISARS IKLVVSQVFT AANYEYLVYW IFRMDGVIEC EIRLTGILNT 

       430        440        450        460        470        480 
NAINEDEDLK GHGTQVYPKI SAENHEHLFC LRINPMLDGL RNSVATVDAL RDKNGTLVSK 

       490        500        510        520        530        540 
YIIPETVTEA ISNYDSSTGR TWDICNLNKL HPYSGKPVSY KLISRDTSPV LSQPGTTNSD 

       550        560        570        580        590        600 
CSGFAENNIY VTPYMDDQIF PTGDYAPQAS DDTPKGLSKW ISDDPNAQIK NTDIVVWHTF 

       610        620        630        640        650        660 
GMIHFPAPED FPIMPAESIH LFLQPRNFFK HNPALDTSSS VNSTSEATSP NTHHENLRDT 

       670        680        690        700        710        720 
SQKRESHSTP HDYEPHVSDK NDKSVEDKLH FVQKDESRPK EPVVDAAQKH EGRSETLAQP 

       730        740        750        760        770        780 
GQQNANQSEE KQGGQNGSNG GHHHHHHHHY ITGHVYGGYH KHSGSGGHLV DMMKNISDVT 

       790 
HDFAMGNFRY HKYD

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329671 Genomic DNA. Translation: CAB38696.1.
PIRT39367.
T39171. T50376.
RefSeqNP_596841.2. NM_001023862.2.

3D structure databases

ProteinModelPortalO42890.
ModBaseSearch...

Protein-protein interaction databases

STRINGO42890.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC1289.16c.1; SPBC1289.16c.1:pep; SPBC1289.16c.
GeneID2539624.
KEGGspo:SPBC1289.16c.

Organism-specific databases

GeneDB_SpombeSPBC1289.16c.

Phylogenomic databases

eggNOGfuNOG06311.
GeneTreeEFGT00050000002396.
HOGENOMHBG325455.
OrthoDBEOG45MRDH.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-004821-MONOMER.

Gene expression databases

ArrayExpressO42890.

Family and domain databases

InterProIPR000269. Cu_amine_oxidase.
IPR015798. Cu_amine_oxidase_C.
IPR016182. Cu_amine_oxidase_N-reg.
IPR015800. Cu_amine_oxidase_N2.
IPR015801. Cu_amine_oxidase_N2/3.
IPR015802. Cu_amine_oxidase_N3.
[Graphical view]
Gene3DG3DSA:3.10.450.40. CuNH_oxidase. 2 hits.
G3DSA:2.70.98.20. Lyase_8_central. 1 hit.
KOK00276.
PANTHERPTHR10638. CuNH_oxidase. 1 hit.
PfamPF01179. Cu_amine_oxid. 1 hit.
PF02727. Cu_amine_oxidN2. 1 hit.
PF02728. Cu_amine_oxidN3. 1 hit.
[Graphical view]
SUPFAMSSF54416. Cu_amine_oxidase_N-reg. 2 hits.
SSF49998. CuNH_oxidase. 1 hit.
PROSITEPS01164. COPPER_AMINE_OXID_1. 1 hit.
PS01165. COPPER_AMINE_OXID_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMOH1_SCHPO
AccessionPrimary (citable) accession number: O42890
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 1998
Last modified: December 14, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents