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Protein

Uncharacterized oxidoreductase C8E4.04

Gene

SPBC8E4.04

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei59Proton donorBy similarity1
Sitei84Lowers pKa of active site TyrBy similarity1
Binding sitei117SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

ReactomeiR-SPO-156590. Glutathione conjugation.
R-SPO-193144. Estrogen biosynthesis.
R-SPO-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-SPO-193775. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
R-SPO-193807. Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
R-SPO-196108. Pregnenolone biosynthesis.
R-SPO-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
R-SPO-5365859. RA biosynthesis pathway.
R-SPO-5652227. Fructose biosynthesis.
R-SPO-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized oxidoreductase C8E4.04 (EC:1.-.-.-)
Gene namesi
ORF Names:SPBC8E4.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC8E4.04.
PomBaseiSPBC8E4.04.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003103091 – 325Uncharacterized oxidoreductase C8E4.04Add BLAST325

Proteomic databases

MaxQBiO42888.
PRIDEiO42888.

Interactioni

Protein-protein interaction databases

MINTiMINT-4673760.

Structurei

3D structure databases

ProteinModelPortaliO42888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

HOGENOMiHOG000250272.
InParanoidiO42888.
OrthoDBiEOG092C324N.
PhylomeDBiO42888.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIKEFAKNA REAYFTLPNG DKIPSIGLGT WRSGKDETKN AVCAALKAGY
60 70 80 90 100
RHIDTAHIYG NEKEIGEGIR ESGVPRTDIW VTSKLWCNAH RAGLVPLALE
110 120 130 140 150
KTLQDLNLEY IDAYLIHWPF ALLSGPEELP RNEKGELIYE DVPIEETWQA
160 170 180 190 200
MEELLETGKV RYIGISNFNN EYLDRVLKIA KVKPTIHQME LHPYLPQTEY
210 220 230 240 250
LEKHKKLQIH VSAYSPLANQ NDAYNSDISK LIEHKTLVDI ANARGEGITP
260 270 280 290 300
ANIAISWAVK RGTSVLPKSV NESRIVSNFL YIPLTDKEME AINNIGVVRR
310 320
FSHGKFAPKP MFVGLQDGTP KQTHA
Length:325
Mass (Da):36,629
Last modified:June 1, 1998 - v1
Checksum:i68ED211F1E4D08D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16997.1.
PIRiT50378. T39169.
RefSeqiNP_596843.1. NM_001023865.2.

Genome annotation databases

EnsemblFungiiSPBC8E4.04.1; SPBC8E4.04.1:pep; SPBC8E4.04.
GeneIDi2541256.
KEGGispo:SPBC8E4.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16997.1.
PIRiT50378. T39169.
RefSeqiNP_596843.1. NM_001023865.2.

3D structure databases

ProteinModelPortaliO42888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4673760.

Proteomic databases

MaxQBiO42888.
PRIDEiO42888.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC8E4.04.1; SPBC8E4.04.1:pep; SPBC8E4.04.
GeneIDi2541256.
KEGGispo:SPBC8E4.04.

Organism-specific databases

EuPathDBiFungiDB:SPBC8E4.04.
PomBaseiSPBC8E4.04.

Phylogenomic databases

HOGENOMiHOG000250272.
InParanoidiO42888.
OrthoDBiEOG092C324N.
PhylomeDBiO42888.

Enzyme and pathway databases

ReactomeiR-SPO-156590. Glutathione conjugation.
R-SPO-193144. Estrogen biosynthesis.
R-SPO-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-SPO-193775. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
R-SPO-193807. Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
R-SPO-196108. Pregnenolone biosynthesis.
R-SPO-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
R-SPO-5365859. RA biosynthesis pathway.
R-SPO-5652227. Fructose biosynthesis.
R-SPO-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Miscellaneous databases

PROiO42888.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYBN4_SCHPO
AccessioniPrimary (citable) accession number: O42888
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.