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Protein

Putative agmatinase 2

Gene

SPBC8E4.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Mn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi206Manganese 1PROSITE-ProRule annotation1
Metal bindingi229Manganese 1PROSITE-ProRule annotation1
Metal bindingi229Manganese 2PROSITE-ProRule annotation1
Metal bindingi231Manganese 2PROSITE-ProRule annotation1
Metal bindingi233Manganese 1PROSITE-ProRule annotation1
Metal bindingi331Manganese 1PROSITE-ProRule annotation1
Metal bindingi331Manganese 2PROSITE-ProRule annotation1
Metal bindingi333Manganese 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-351143. Agmatine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative agmatinase 2 (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase 2
Short name:
AUH 2
Gene namesi
ORF Names:SPBC8E4.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC8E4.03.
PomBaseiSPBC8E4.03.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: PomBase
  • fungal-type vacuole Source: PomBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000209223 – 413Putative agmatinase 2Add BLAST391

Proteomic databases

MaxQBiO42887.
PRIDEiO42887.

Interactioni

Protein-protein interaction databases

BioGridi277792. 19 interactors.
MINTiMINT-4673750.

Structurei

3D structure databases

ProteinModelPortaliO42887.
SMRiO42887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000204320.
InParanoidiO42887.
KOiK01480.
OMAiQFNHGSM.
OrthoDBiEOG092C3B4E.
PhylomeDBiO42887.

Family and domain databases

InterProiView protein in InterPro
IPR006035. Ureohydrolase.
IPR020855. Ureohydrolase_Mn_BS.
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiView protein in Pfam
PF00491. Arginase. 1 hit.
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
PROSITEiView protein in PROSITE
PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTYQKIIQL ALLLSGVCGA LASIDTDSHL SPKVLEKLRP TENLAYEDDS
60 70 80 90 100
LDDDTWRSKR WEFDYQYSGI STFAHLPHVR CLVEQSEDFD IAIIGVPFDT
110 120 130 140 150
AVSHRPGARF GPKGIRSASS RQMAIRGFNP SLNVNPYESW AKILDCGDIP
160 170 180 190 200
VSSYDNQLAV RQMTEGYIDL LSRKATASPA SNNLKTAGLA KDGIFHPRLI
210 220 230 240 250
TLGGDHSIGL ASLRALGHFY GNVSVIHFDS HLDTWNPKRY YPSYWHSDRA
260 270 280 290 300
DFTHGTMFWM ASKEGLINNG TSIHAGLRTR LSGTDYYDYE EDNRVGFTFI
310 320 330 340 350
EAQEIDEIGV NGIVERIKQV VGDTLVYLSI DIDVVDPGLA PGTGTPETGG
360 370 380 390 400
WTTREMKSIL RKLDGHLNLV GAEVVEVSPP YDDRAESTSL AASDFIFEIL
410
SSMVKHPLYD VKK
Length:413
Mass (Da):45,902
Last modified:June 1, 1998 - v1
Checksum:i577EF7AF936E1346
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16996.1.
PIRiT50379. T39168.
RefSeqiNP_596844.1. NM_001023866.2.

Genome annotation databases

EnsemblFungiiSPBC8E4.03.1; SPBC8E4.03.1:pep; SPBC8E4.03.
GeneIDi2541279.
KEGGispo:SPBC8E4.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16996.1.
PIRiT50379. T39168.
RefSeqiNP_596844.1. NM_001023866.2.

3D structure databases

ProteinModelPortaliO42887.
SMRiO42887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277792. 19 interactors.
MINTiMINT-4673750.

Proteomic databases

MaxQBiO42887.
PRIDEiO42887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC8E4.03.1; SPBC8E4.03.1:pep; SPBC8E4.03.
GeneIDi2541279.
KEGGispo:SPBC8E4.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC8E4.03.
PomBaseiSPBC8E4.03.

Phylogenomic databases

HOGENOMiHOG000204320.
InParanoidiO42887.
KOiK01480.
OMAiQFNHGSM.
OrthoDBiEOG092C3B4E.
PhylomeDBiO42887.

Enzyme and pathway databases

ReactomeiR-SPO-351143. Agmatine biosynthesis.

Miscellaneous databases

PROiPR:O42887.

Family and domain databases

InterProiView protein in InterPro
IPR006035. Ureohydrolase.
IPR020855. Ureohydrolase_Mn_BS.
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiView protein in Pfam
PF00491. Arginase. 1 hit.
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
PROSITEiView protein in PROSITE
PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPEB2_SCHPO
AccessioniPrimary (citable) accession number: O42887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: April 12, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.