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O42887

- SPEB2_SCHPO

UniProt

O42887 - SPEB2_SCHPO

Protein

Putative agmatinase 2

Gene

SPBC8E4.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Agmatine + H2O = putrescine + urea.

    Cofactori

    Manganese.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi206 – 2061Manganese 1PROSITE-ProRule annotation
    Metal bindingi229 – 2291Manganese 1PROSITE-ProRule annotation
    Metal bindingi229 – 2291Manganese 2PROSITE-ProRule annotation
    Metal bindingi231 – 2311Manganese 2PROSITE-ProRule annotation
    Metal bindingi233 – 2331Manganese 1PROSITE-ProRule annotation
    Metal bindingi331 – 3311Manganese 1PROSITE-ProRule annotation
    Metal bindingi331 – 3311Manganese 2PROSITE-ProRule annotation
    Metal bindingi333 – 3331Manganese 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. agmatinase activity Source: UniProtKB-EC
    2. manganese ion binding Source: PomBase

    GO - Biological processi

    1. cellular amino acid metabolic process Source: PomBase
    2. urea metabolic process Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative agmatinase 2 (EC:3.5.3.11)
    Alternative name(s):
    Agmatine ureohydrolase 2
    Short name:
    AUH 2
    Gene namesi
    ORF Names:SPBC8E4.03
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC8E4.03.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: PomBase
    2. fungal-type vacuole Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 413391Putative agmatinase 2PRO_0000002092Add
    BLAST

    Proteomic databases

    MaxQBiO42887.

    Interactioni

    Protein-protein interaction databases

    BioGridi277792. 18 interactions.
    MINTiMINT-4673750.
    STRINGi4896.SPBC8E4.03-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO42887.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arginase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0010.
    HOGENOMiHOG000204320.
    KOiK01480.
    OMAiCGPIHRI.
    OrthoDBiEOG718KPD.
    PhylomeDBiO42887.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    InterProiIPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    PRINTSiPR00116. ARGINASE.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O42887-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTYQKIIQL ALLLSGVCGA LASIDTDSHL SPKVLEKLRP TENLAYEDDS    50
    LDDDTWRSKR WEFDYQYSGI STFAHLPHVR CLVEQSEDFD IAIIGVPFDT 100
    AVSHRPGARF GPKGIRSASS RQMAIRGFNP SLNVNPYESW AKILDCGDIP 150
    VSSYDNQLAV RQMTEGYIDL LSRKATASPA SNNLKTAGLA KDGIFHPRLI 200
    TLGGDHSIGL ASLRALGHFY GNVSVIHFDS HLDTWNPKRY YPSYWHSDRA 250
    DFTHGTMFWM ASKEGLINNG TSIHAGLRTR LSGTDYYDYE EDNRVGFTFI 300
    EAQEIDEIGV NGIVERIKQV VGDTLVYLSI DIDVVDPGLA PGTGTPETGG 350
    WTTREMKSIL RKLDGHLNLV GAEVVEVSPP YDDRAESTSL AASDFIFEIL 400
    SSMVKHPLYD VKK 413
    Length:413
    Mass (Da):45,902
    Last modified:June 1, 1998 - v1
    Checksum:i577EF7AF936E1346
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA16996.1.
    PIRiT50379. T39168.
    RefSeqiNP_596844.1. NM_001023866.2.

    Genome annotation databases

    EnsemblFungiiSPBC8E4.03.1; SPBC8E4.03.1:pep; SPBC8E4.03.
    GeneIDi2541279.
    KEGGispo:SPBC8E4.03.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA16996.1 .
    PIRi T50379. T39168.
    RefSeqi NP_596844.1. NM_001023866.2.

    3D structure databases

    ProteinModelPortali O42887.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277792. 18 interactions.
    MINTi MINT-4673750.
    STRINGi 4896.SPBC8E4.03-1.

    Proteomic databases

    MaxQBi O42887.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC8E4.03.1 ; SPBC8E4.03.1:pep ; SPBC8E4.03 .
    GeneIDi 2541279.
    KEGGi spo:SPBC8E4.03.

    Organism-specific databases

    PomBasei SPBC8E4.03.

    Phylogenomic databases

    eggNOGi COG0010.
    HOGENOMi HOG000204320.
    KOi K01480.
    OMAi CGPIHRI.
    OrthoDBi EOG718KPD.
    PhylomeDBi O42887.

    Miscellaneous databases

    NextBioi 20802390.

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    InterProi IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    PRINTSi PR00116. ARGINASE.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiSPEB2_SCHPO
    AccessioniPrimary (citable) accession number: O42887
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3