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O42887

- SPEB2_SCHPO

UniProt

O42887 - SPEB2_SCHPO

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Protein
Putative agmatinase 2
Gene
SPBC8E4.03
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Manganese Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi206 – 2061Manganese 1 By similarity
Metal bindingi229 – 2291Manganese 1 By similarity
Metal bindingi229 – 2291Manganese 2 By similarity
Metal bindingi231 – 2311Manganese 2 By similarity
Metal bindingi233 – 2331Manganese 1 By similarity
Metal bindingi331 – 3311Manganese 1 By similarity
Metal bindingi331 – 3311Manganese 2 By similarity
Metal bindingi333 – 3331Manganese 2 By similarity

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-EC
  2. manganese ion binding Source: PomBase

GO - Biological processi

  1. cellular amino acid metabolic process Source: PomBase
  2. urea metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative agmatinase 2 (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase 2
Short name:
AUH 2
Gene namesi
ORF Names:SPBC8E4.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC8E4.03.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
  2. fungal-type vacuole Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 413391Putative agmatinase 2
PRO_0000002092Add
BLAST

Proteomic databases

MaxQBiO42887.

Interactioni

Protein-protein interaction databases

BioGridi277792. 18 interactions.
MINTiMINT-4673750.
STRINGi4896.SPBC8E4.03-1.

Structurei

3D structure databases

ProteinModelPortaliO42887.

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204320.
KOiK01480.
OMAiCGPIHRI.
OrthoDBiEOG718KPD.
PhylomeDBiO42887.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42887-1 [UniParc]FASTAAdd to Basket

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MFTYQKIIQL ALLLSGVCGA LASIDTDSHL SPKVLEKLRP TENLAYEDDS    50
LDDDTWRSKR WEFDYQYSGI STFAHLPHVR CLVEQSEDFD IAIIGVPFDT 100
AVSHRPGARF GPKGIRSASS RQMAIRGFNP SLNVNPYESW AKILDCGDIP 150
VSSYDNQLAV RQMTEGYIDL LSRKATASPA SNNLKTAGLA KDGIFHPRLI 200
TLGGDHSIGL ASLRALGHFY GNVSVIHFDS HLDTWNPKRY YPSYWHSDRA 250
DFTHGTMFWM ASKEGLINNG TSIHAGLRTR LSGTDYYDYE EDNRVGFTFI 300
EAQEIDEIGV NGIVERIKQV VGDTLVYLSI DIDVVDPGLA PGTGTPETGG 350
WTTREMKSIL RKLDGHLNLV GAEVVEVSPP YDDRAESTSL AASDFIFEIL 400
SSMVKHPLYD VKK 413
Length:413
Mass (Da):45,902
Last modified:June 1, 1998 - v1
Checksum:i577EF7AF936E1346
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA16996.1.
PIRiT50379. T39168.
RefSeqiNP_596844.1. NM_001023866.2.

Genome annotation databases

EnsemblFungiiSPBC8E4.03.1; SPBC8E4.03.1:pep; SPBC8E4.03.
GeneIDi2541279.
KEGGispo:SPBC8E4.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA16996.1 .
PIRi T50379. T39168.
RefSeqi NP_596844.1. NM_001023866.2.

3D structure databases

ProteinModelPortali O42887.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277792. 18 interactions.
MINTi MINT-4673750.
STRINGi 4896.SPBC8E4.03-1.

Proteomic databases

MaxQBi O42887.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC8E4.03.1 ; SPBC8E4.03.1:pep ; SPBC8E4.03 .
GeneIDi 2541279.
KEGGi spo:SPBC8E4.03.

Organism-specific databases

PomBasei SPBC8E4.03.

Phylogenomic databases

eggNOGi COG0010.
HOGENOMi HOG000204320.
KOi K01480.
OMAi CGPIHRI.
OrthoDBi EOG718KPD.
PhylomeDBi O42887.

Miscellaneous databases

NextBioi 20802390.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
InterProi IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
PRINTSi PR00116. ARGINASE.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiSPEB2_SCHPO
AccessioniPrimary (citable) accession number: O42887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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