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Protein

Tryptophan--tRNA ligase, mitochondrial

Gene

msw1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21ATPBy similarity1
Binding sitei165L-tryptophanBy similarity1
Binding sitei228ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 30ATPBy similarity4
Nucleotide bindingi177 – 179ATPBy similarity3
Nucleotide bindingi225 – 229ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase, mitochondrial (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:msw1Imported
ORF Names:SPAC3G9.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPAC3G9.13c
PomBaseiSPAC3G9.13c msw1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionBy similarityAdd BLAST16
ChainiPRO_000031463117 – 361Tryptophan--tRNA ligase, mitochondrialAdd BLAST345

Proteomic databases

MaxQBiO42875
PaxDbiO42875
PRIDEiO42875

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi4896.SPAC3G9.13c.1

Structurei

3D structure databases

ProteinModelPortaliO42875
SMRiO42875
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 30"HIGH" regionSequence analysis9
Motifi225 – 229"KMSKS" regionSequence analysis5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.Sequence analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000059940
InParanoidiO42875
KOiK01867
OMAiQRMTQFK
OrthoDBiEOG092C3VLE
PhylomeDBiO42875

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLPKITSL LPHSRVVSGI QPTGIPHIGN YLGSLKQWVQ LQEEAARTPF
60 70 80 90 100
SKCFFFVADL HALTVPQDPL KFRQARLDML AALLAIGINP QKSTLFFQSD
110 120 130 140 150
VAQHSELAWL LACSTSMGQL NRMTQWKSKL HLHDHDDLSF LDASATSSTR
160 170 180 190 200
FNLGLFSYPV LQAADILLYG ATHIPVGKDQ SQHVELTRSI ARSFNSSYKE
210 220 230 240 250
KILTVPDIIL NSSSSIMALC QPEKKMSKSD INSKNYILLS DSTGEIRKKI
260 270 280 290 300
SRAQTDNIKG ITYGDSNRPG INNLINIFAA ISDSTPSDIA QANASCSNAE
310 320 330 340 350
FKEKVSSAII RCLQPISTSF NEWRQNRELL RDIAKKGAEE AVAEASSCMH
360
KLKTLTGLSV Y
Length:361
Mass (Da):39,870
Last modified:June 1, 1998 - v1
Checksum:i7889FCC85731CA72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA15922.1
PIRiT11649
RefSeqiNP_594085.1, NM_001019500.2

Genome annotation databases

EnsemblFungiiSPAC3G9.13c.1; SPAC3G9.13c.1:pep; SPAC3G9.13c
GeneIDi2543249
KEGGispo:SPAC3G9.13c

Similar proteinsi

Entry informationi

Entry nameiSYWM_SCHPO
AccessioniPrimary (citable) accession number: O42875
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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