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Protein

RNA polymerase II subunit A C-terminal domain phosphatase ssu72

Gene

ssu72

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (rpb1).By similarity
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Ssu72 is required for 3'-end formation of snoRNAs (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW
  2. phosphoric ester hydrolase activity Source: PomBase

GO - Biological processi

  1. DNA-templated transcription, initiation Source: PomBase
  2. mRNA processing Source: UniProtKB-KW
  3. negative regulation of chromosome condensation Source: PomBase
  4. termination of RNA polymerase II transcription Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase ssu72 (EC:3.1.3.16)
Short name:
CTD phosphatase ssu72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:ssu72
ORF Names:SPAC3G9.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

PomBaseiSPAC3G9.04.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. mRNA cleavage and polyadenylation specificity factor complex Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197RNA polymerase II subunit A C-terminal domain phosphatase ssu72PRO_0000255612Add
BLAST

Proteomic databases

MaxQBiO42868.

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of cft1, cft2, ysh1, pta1, swd2, pfs2, dis2, yth1, ssu72, and fip1.1 Publication

Protein-protein interaction databases

BioGridi279872. 176 interactions.
MINTiMINT-4673625.
STRINGi4896.SPAC3G9.04-1.

Structurei

3D structure databases

ProteinModelPortaliO42868.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
InParanoidiO42868.
KOiK15544.
OMAiGEYNRPI.
OrthoDBiEOG7GTTG0.
PhylomeDBiO42868.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKTNLQIS VICASNQNRS MEAHNVLKNA GYQVDSFGTG SAVRLPGPSI
60 70 80 90 100
DKPNIYQFGY PYDEIYKELE AQDSRLYTAN GLLKMLDRNR RIKRAPCRWQ
110 120 130 140 150
DQDSIYNIVI TCEERCYDAI CEDLYRRGET LNRPVYLINV DIKDNHEEAS
160 170 180 190
VGGKAILDLV NKLTEAQDKL EELFPSIMAD FQSNHPKLPV LYTIHFF
Length:197
Mass (Da):22,596
Last modified:May 31, 1998 - v1
Checksum:i04BE20BEF08D76BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA15913.1.
PIRiT11640.
RefSeqiNP_594076.1. NM_001019509.2.

Genome annotation databases

EnsemblFungiiSPAC3G9.04.1; SPAC3G9.04.1:pep; SPAC3G9.04.
GeneIDi2543452.
KEGGispo:SPAC3G9.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA15913.1.
PIRiT11640.
RefSeqiNP_594076.1. NM_001019509.2.

3D structure databases

ProteinModelPortaliO42868.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279872. 176 interactions.
MINTiMINT-4673625.
STRINGi4896.SPAC3G9.04-1.

Proteomic databases

MaxQBiO42868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC3G9.04.1; SPAC3G9.04.1:pep; SPAC3G9.04.
GeneIDi2543452.
KEGGispo:SPAC3G9.04.

Organism-specific databases

PomBaseiSPAC3G9.04.

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
InParanoidiO42868.
KOiK15544.
OMAiGEYNRPI.
OrthoDBiEOG7GTTG0.
PhylomeDBiO42868.

Miscellaneous databases

NextBioi20804465.
PROiO42868.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe."
    Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F., Shevchenko A.
    Mol. Cell. Proteomics 3:125-132(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CPF COMPLEX.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSSU72_SCHPO
AccessioniPrimary (citable) accession number: O42868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 30, 2006
Last sequence update: May 31, 1998
Last modified: March 31, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.