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O42868

- SSU72_SCHPO

UniProt

O42868 - SSU72_SCHPO

Protein

RNA polymerase II subunit A C-terminal domain phosphatase ssu72

Gene

ssu72

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (rpb1).By similarity
    Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Ssu72 is required for 3'-end formation of snoRNAs By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW
    2. phosphoric ester hydrolase activity Source: PomBase

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: PomBase
    2. mRNA processing Source: UniProtKB-KW
    3. termination of RNA polymerase II transcription Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    mRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase ssu72 (EC:3.1.3.16)
    Short name:
    CTD phosphatase ssu72
    Alternative name(s):
    Suppressor of SUA7 protein 2 homolog
    Gene namesi
    Name:ssu72
    ORF Names:SPAC3G9.04
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC3G9.04.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. mRNA cleavage and polyadenylation specificity factor complex Source: PomBase
    3. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 197197RNA polymerase II subunit A C-terminal domain phosphatase ssu72PRO_0000255612Add
    BLAST

    Proteomic databases

    MaxQBiO42868.

    Interactioni

    Subunit structurei

    Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of cft1, cft2, ysh1, pta1, swd2, pfs2, dis2, yth1, ssu72, and fip1.1 Publication

    Protein-protein interaction databases

    BioGridi279872. 172 interactions.
    MINTiMINT-4673625.
    STRINGi4896.SPAC3G9.04-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO42868.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SSU72 phosphatase family.Curated

    Phylogenomic databases

    eggNOGiCOG5211.
    HOGENOMiHOG000183445.
    KOiK15544.
    OMAiMAKSNDI.
    OrthoDBiEOG7GTTG0.
    PhylomeDBiO42868.

    Family and domain databases

    InterProiIPR006811. RNA_pol_II_suA.
    [Graphical view]
    PANTHERiPTHR20383. PTHR20383. 1 hit.
    PfamiPF04722. Ssu72. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42868-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPKTNLQIS VICASNQNRS MEAHNVLKNA GYQVDSFGTG SAVRLPGPSI    50
    DKPNIYQFGY PYDEIYKELE AQDSRLYTAN GLLKMLDRNR RIKRAPCRWQ 100
    DQDSIYNIVI TCEERCYDAI CEDLYRRGET LNRPVYLINV DIKDNHEEAS 150
    VGGKAILDLV NKLTEAQDKL EELFPSIMAD FQSNHPKLPV LYTIHFF 197
    Length:197
    Mass (Da):22,596
    Last modified:June 1, 1998 - v1
    Checksum:i04BE20BEF08D76BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA15913.1.
    PIRiT11640.
    RefSeqiNP_594076.1. NM_001019509.2.

    Genome annotation databases

    EnsemblFungiiSPAC3G9.04.1; SPAC3G9.04.1:pep; SPAC3G9.04.
    GeneIDi2543452.
    KEGGispo:SPAC3G9.04.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA15913.1 .
    PIRi T11640.
    RefSeqi NP_594076.1. NM_001019509.2.

    3D structure databases

    ProteinModelPortali O42868.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279872. 172 interactions.
    MINTi MINT-4673625.
    STRINGi 4896.SPAC3G9.04-1.

    Proteomic databases

    MaxQBi O42868.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC3G9.04.1 ; SPAC3G9.04.1:pep ; SPAC3G9.04 .
    GeneIDi 2543452.
    KEGGi spo:SPAC3G9.04.

    Organism-specific databases

    PomBasei SPAC3G9.04.

    Phylogenomic databases

    eggNOGi COG5211.
    HOGENOMi HOG000183445.
    KOi K15544.
    OMAi MAKSNDI.
    OrthoDBi EOG7GTTG0.
    PhylomeDBi O42868.

    Miscellaneous databases

    NextBioi 20804465.
    PROi O42868.

    Family and domain databases

    InterProi IPR006811. RNA_pol_II_suA.
    [Graphical view ]
    PANTHERi PTHR20383. PTHR20383. 1 hit.
    Pfami PF04722. Ssu72. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe."
      Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F., Shevchenko A.
      Mol. Cell. Proteomics 3:125-132(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CPF COMPLEX.
    3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSSU72_SCHPO
    AccessioniPrimary (citable) accession number: O42868
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3