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O42868

- SSU72_SCHPO

UniProt

O42868 - SSU72_SCHPO

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Protein

RNA polymerase II subunit A C-terminal domain phosphatase ssu72

Gene
ssu72, SPAC3G9.04
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (rpb1) By similarity.
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Ssu72 is required for 3'-end formation of snoRNAs By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW
  2. phosphoric ester hydrolase activity Source: PomBase

GO - Biological processi

  1. DNA-templated transcription, initiation Source: PomBase
  2. mRNA processing Source: UniProtKB-KW
  3. termination of RNA polymerase II transcription Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase ssu72 (EC:3.1.3.16)
Short name:
CTD phosphatase ssu72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:ssu72
ORF Names:SPAC3G9.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC3G9.04.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. mRNA cleavage and polyadenylation specificity factor complex Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197RNA polymerase II subunit A C-terminal domain phosphatase ssu72PRO_0000255612Add
BLAST

Proteomic databases

MaxQBiO42868.

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of cft1, cft2, ysh1, pta1, swd2, pfs2, dis2, yth1, ssu72, and fip1.1 Publication

Protein-protein interaction databases

BioGridi279872. 172 interactions.
MINTiMINT-4673625.
STRINGi4896.SPAC3G9.04-1.

Structurei

3D structure databases

ProteinModelPortaliO42868.

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
KOiK15544.
OMAiMAKSNDI.
OrthoDBiEOG7GTTG0.
PhylomeDBiO42868.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42868-1 [UniParc]FASTAAdd to Basket

« Hide

MAPKTNLQIS VICASNQNRS MEAHNVLKNA GYQVDSFGTG SAVRLPGPSI    50
DKPNIYQFGY PYDEIYKELE AQDSRLYTAN GLLKMLDRNR RIKRAPCRWQ 100
DQDSIYNIVI TCEERCYDAI CEDLYRRGET LNRPVYLINV DIKDNHEEAS 150
VGGKAILDLV NKLTEAQDKL EELFPSIMAD FQSNHPKLPV LYTIHFF 197
Length:197
Mass (Da):22,596
Last modified:June 1, 1998 - v1
Checksum:i04BE20BEF08D76BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA15913.1.
PIRiT11640.
RefSeqiNP_594076.1. NM_001019509.2.

Genome annotation databases

EnsemblFungiiSPAC3G9.04.1; SPAC3G9.04.1:pep; SPAC3G9.04.
GeneIDi2543452.
KEGGispo:SPAC3G9.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA15913.1 .
PIRi T11640.
RefSeqi NP_594076.1. NM_001019509.2.

3D structure databases

ProteinModelPortali O42868.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279872. 172 interactions.
MINTi MINT-4673625.
STRINGi 4896.SPAC3G9.04-1.

Proteomic databases

MaxQBi O42868.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC3G9.04.1 ; SPAC3G9.04.1:pep ; SPAC3G9.04 .
GeneIDi 2543452.
KEGGi spo:SPAC3G9.04.

Organism-specific databases

PomBasei SPAC3G9.04.

Phylogenomic databases

eggNOGi COG5211.
HOGENOMi HOG000183445.
KOi K15544.
OMAi MAKSNDI.
OrthoDBi EOG7GTTG0.
PhylomeDBi O42868.

Miscellaneous databases

NextBioi 20804465.
PROi O42868.

Family and domain databases

InterProi IPR006811. RNA_pol_II_suA.
[Graphical view ]
PANTHERi PTHR20383. PTHR20383. 1 hit.
Pfami PF04722. Ssu72. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe."
    Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F., Shevchenko A.
    Mol. Cell. Proteomics 3:125-132(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CPF COMPLEX.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSSU72_SCHPO
AccessioniPrimary (citable) accession number: O42868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 1998
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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