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Protein

Mitotic checkpoint protein bub3

Gene

bub3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell cycle checkpoint enforcement. Involved in recruitment of checkpoint proteins bub1 and mad3 to the kinetochores, ensuring correct spindle checkpoint function.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cellular protein localization Source: PomBase
  • mitotic nuclear division Source: UniProtKB-KW
  • mitotic spindle assembly checkpoint Source: PomBase
  • signal transduction involved in mitotic spindle assembly checkpoint Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Mitotic checkpoint protein bub3
Gene namesi
Name:bub3
ORF Names:SPAC23H3.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23H3.08c.
PomBaseiSPAC23H3.08c. bub3.

Subcellular locationi

GO - Cellular componenti

  • bub1-bub3 complex Source: PomBase
  • condensed nuclear chromosome kinetochore Source: PomBase
  • mitotic checkpoint complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345601 – 320Mitotic checkpoint protein bub3Add BLAST320

Post-translational modificationi

Phosphorylated by bub1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO42860.
PRIDEiO42860.

Interactioni

Subunit structurei

Interacts with bub1 and mad3.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278347. 59 interactors.
DIPiDIP-39398N.
IntActiO42860. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliO42860.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 50WD 1Add BLAST41
Repeati53 – 91WD 2Add BLAST39
Repeati93 – 132WD 3Add BLAST40
Repeati231 – 270WD 4Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat BUB3 family.Curated
Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000208822.
InParanoidiO42860.
KOiK02180.
OMAiEGEKSHE.
OrthoDBiEOG092C4UMO.
PhylomeDBiO42860.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFSKTLLKN SKDGISSVIF SPSVKNELIA GCWDGSLLHY QISENPELLG
60 70 80 90 100
KYDLSSPILS LEYTDEKTAL VGNLDGTVTT LDLNTRNHEF LGNHGKGVSC
110 120 130 140 150
ISKLRLENCF ISGSWDKSFR VWDVRVKQPV EGQDIGKKIF ASSSRDNILV
160 170 180 190 200
LGCSERENLV YDIRNLKLPF QRRPSSFKYM TRSVCCNQNF EGFVSSSIEG
210 220 230 240 250
RTSVEYINPS QEAQSKNFTF KCHRQIQKDY DIVYPVNDLK FHPIHQTLAT
260 270 280 290 300
AGGDGVVAFW DIQVRKRLRV LNPSKINISS ISFNVDGSML AIATCAQEEA
310 320
AGNIYVHALE SNFAAPKLKS
Length:320
Mass (Da):35,804
Last modified:June 1, 1998 - v1
Checksum:iA5028C58CEBEED43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16243.1.
PIRiT38301.
RefSeqiNP_593798.1. NM_001019227.2.

Genome annotation databases

EnsemblFungiiSPAC23H3.08c.1; SPAC23H3.08c.1:pep; SPAC23H3.08c.
GeneIDi2541856.
KEGGispo:SPAC23H3.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16243.1.
PIRiT38301.
RefSeqiNP_593798.1. NM_001019227.2.

3D structure databases

ProteinModelPortaliO42860.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278347. 59 interactors.
DIPiDIP-39398N.
IntActiO42860. 1 interactor.

Proteomic databases

MaxQBiO42860.
PRIDEiO42860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23H3.08c.1; SPAC23H3.08c.1:pep; SPAC23H3.08c.
GeneIDi2541856.
KEGGispo:SPAC23H3.08c.

Organism-specific databases

EuPathDBiFungiDB:SPAC23H3.08c.
PomBaseiSPAC23H3.08c. bub3.

Phylogenomic databases

HOGENOMiHOG000208822.
InParanoidiO42860.
KOiK02180.
OMAiEGEKSHE.
OrthoDBiEOG092C4UMO.
PhylomeDBiO42860.

Miscellaneous databases

PROiO42860.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBUB3_SCHPO
AccessioniPrimary (citable) accession number: O42860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.