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Protein

Mitotic checkpoint protein bub3

Gene

bub3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cell cycle checkpoint enforcement. Involved in recruitment of checkpoint proteins bub1 and mad3 to the kinetochores, ensuring correct spindle checkpoint function.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cellular protein localization Source: PomBase
  • mitotic spindle assembly checkpoint Source: PomBase
  • signal transduction involved in mitotic spindle assembly checkpoint Source: PomBase

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Mitotic checkpoint protein bub3
Gene namesi
Name:bub3
ORF Names:SPAC23H3.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23H3.08c
PomBaseiSPAC23H3.08c bub3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345601 – 320Mitotic checkpoint protein bub3Add BLAST320

Post-translational modificationi

Phosphorylated by bub1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO42860
PaxDbiO42860
PRIDEiO42860

Interactioni

Subunit structurei

Interacts with bub1 and mad3.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278347, 60 interactors
DIPiDIP-39398N
IntActiO42860, 3 interactors
STRINGi4896.SPAC23H3.08c.1

Structurei

3D structure databases

ProteinModelPortaliO42860
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 50WD 1Add BLAST41
Repeati53 – 91WD 2Add BLAST39
Repeati93 – 132WD 3Add BLAST40
Repeati231 – 270WD 4Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat BUB3 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000208822
InParanoidiO42860
KOiK02180
OMAiCMPNDAG
OrthoDBiEOG092C4UMO
PhylomeDBiO42860

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

O42860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFSKTLLKN SKDGISSVIF SPSVKNELIA GCWDGSLLHY QISENPELLG
60 70 80 90 100
KYDLSSPILS LEYTDEKTAL VGNLDGTVTT LDLNTRNHEF LGNHGKGVSC
110 120 130 140 150
ISKLRLENCF ISGSWDKSFR VWDVRVKQPV EGQDIGKKIF ASSSRDNILV
160 170 180 190 200
LGCSERENLV YDIRNLKLPF QRRPSSFKYM TRSVCCNQNF EGFVSSSIEG
210 220 230 240 250
RTSVEYINPS QEAQSKNFTF KCHRQIQKDY DIVYPVNDLK FHPIHQTLAT
260 270 280 290 300
AGGDGVVAFW DIQVRKRLRV LNPSKINISS ISFNVDGSML AIATCAQEEA
310 320
AGNIYVHALE SNFAAPKLKS
Length:320
Mass (Da):35,804
Last modified:June 1, 1998 - v1
Checksum:iA5028C58CEBEED43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16243.1
PIRiT38301
RefSeqiNP_593798.1, NM_001019227.2

Genome annotation databases

EnsemblFungiiSPAC23H3.08c.1; SPAC23H3.08c.1:pep; SPAC23H3.08c
GeneIDi2541856
KEGGispo:SPAC23H3.08c

Similar proteinsi

Entry informationi

Entry nameiBUB3_SCHPO
AccessioniPrimary (citable) accession number: O42860
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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