O42831 (YA075_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative inosine-5'-monophosphate dehydrogenase-like protein YAR075W

Gene names

Ordered Locus Names:

YAR075W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	157 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Sequence similarities	Belongs to the IMPDH/GMPR family.
Caution	Could be the product of a pseudogene. In strain S288c, this gene has a frameshift compared to the other IMD alleles, producing 2 ORFs YAR073W and YAR075W.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	IMP dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 157	157	Putative inosine-5'-monophosphate dehydrogenase-like protein YAR075W		PRO_0000248413
Amino acid modifications
	Modified residue	54	1	Phosphoserine Ref.5
	Modified residue	74	1	Phosphoserine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	O42831 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 90F3FCF03C244FCF	FASTA	157	17,003
	10 20 30 40 50 60 MVVFKNIGHI ITKALALGSS TVMMGGMLAG TTESPGEYLY QDGKRLKAYR GMGSIDAMQK 70 80 90 100 110 120 TGTKGNASTS RYFSESDSVL VAQGVSGAVV DKGSIKKFIP YLYNGLQHSC QDIGCRSLTL 130 140 150 LKENVQSGKV RFEFRTASAQ LEGGVNNLHS YEKRLHN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52 Kbp CDC15-FLO1-PHO11-YAR074 region." Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B., Kaback D.B., Clark M.W. Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K. Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast." Hyle J.W., Shaw R.J., Reines D. J. Biol. Chem. 278:28470-28478(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS PSEUDOGENE.
[5]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54 AND SER-74, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L28920 Genomic DNA. Translation: AAC09511.1. AY692623 Genomic DNA. Translation: AAT92642.1.
PIR	S78078.
3D structure databases
ProteinModelPortal	O42831.
SMR	O42831. Positions 6-138.
ModBase	Search...
Protein-protein interaction databases
IntAct	O42831. 1 interaction.
MINT	MINT-2491807.
STRING	4932.YAR075W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YAR075W; YAR075W; YAR075W.
Organism-specific databases
SGD	S000002145. YAR075W.
Phylogenomic databases
HOGENOM	HOG000083425.
Gene expression databases
Genevestigator	O42831.
GermOnline	YAR075W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR005990. IMP_DH. IPR001093. IMP_DH_GMPRt. [Graphical view]
PANTHER	PTHR11911:SF6. PTHR11911:SF6. 1 hit.
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YA075_YEAST

Accession

Primary (citable) accession number: O42831

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	June 1, 1998
Last modified:	May 29, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program