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Protein

Putative inosine-5'-monophosphate dehydrogenase-like protein YAR075W

Gene

YAR075W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_301060. Purine ribonucleoside monophosphate biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inosine-5'-monophosphate dehydrogenase-like protein YAR075W
Gene namesi
Ordered Locus Names:YAR075W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome I

Organism-specific databases

SGDiS000002145. YAR075W.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Putative inosine-5'-monophosphate dehydrogenase-like protein YAR075WPRO_0000248413Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiO42831. 1 interaction.
MINTiMINT-2491807.
STRINGi4932.YAR075W.

Structurei

3D structure databases

ProteinModelPortaliO42831.
SMRiO42831. Positions 6-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.Curated

Phylogenomic databases

HOGENOMiHOG000083425.
OMAiFKNIGHI.
OrthoDBiEOG793BHK.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVFKNIGHI ITKALALGSS TVMMGGMLAG TTESPGEYLY QDGKRLKAYR
60 70 80 90 100
GMGSIDAMQK TGTKGNASTS RYFSESDSVL VAQGVSGAVV DKGSIKKFIP
110 120 130 140 150
YLYNGLQHSC QDIGCRSLTL LKENVQSGKV RFEFRTASAQ LEGGVNNLHS

YEKRLHN
Length:157
Mass (Da):17,003
Last modified:June 1, 1998 - v1
Checksum:i90F3FCF03C244FCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28920 Genomic DNA. Translation: AAC09511.1.
AY692623 Genomic DNA. Translation: AAT92642.1.
BK006935 Genomic DNA. No translation available.
PIRiS78078.

Genome annotation databases

EnsemblFungiiYAR075W; YAR075W; YAR075W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28920 Genomic DNA. Translation: AAC09511.1.
AY692623 Genomic DNA. Translation: AAT92642.1.
BK006935 Genomic DNA. No translation available.
PIRiS78078.

3D structure databases

ProteinModelPortaliO42831.
SMRiO42831. Positions 6-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO42831. 1 interaction.
MINTiMINT-2491807.
STRINGi4932.YAR075W.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAR075W; YAR075W; YAR075W.

Organism-specific databases

SGDiS000002145. YAR075W.

Phylogenomic databases

HOGENOMiHOG000083425.
OMAiFKNIGHI.
OrthoDBiEOG793BHK.

Enzyme and pathway databases

ReactomeiREACT_301060. Purine ribonucleoside monophosphate biosynthesis.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52 Kbp CDC15-FLO1-PHO11-YAR074 region."
    Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B., Kaback D.B., Clark M.W.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast."
    Hyle J.W., Shaw R.J., Reines D.
    J. Biol. Chem. 278:28470-28478(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS PSEUDOGENE.

Entry informationi

Entry nameiYA075_YEAST
AccessioniPrimary (citable) accession number: O42831
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 1998
Last modified: June 24, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene. In strain S288c, this gene has a frameshift compared to the other IMD alleles, producing 2 ORFs YAR073W and YAR075W.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.