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Protein

Xylanolytic transcriptional activator xlnR

Gene

xlnR

Organism
Aspergillus niger
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator of the xylanolytic system. Involved in the regulation of extracellular cellulolytic and xylanolytic genes and in the regulation of the intracellular activities of D-xylose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of D-xylose. Binds to the DNA sequence 5'-GGNTAAA-3'.10 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi125 – 15127Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Xylanolytic transcriptional activator xlnR
Alternative name(s):
Xylanase regulator
Gene namesi
Name:xlnR
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Reduces growth on birchwod xylan, while growth is unaffected on D-xylose, xylitol and other carbon sources like D-glucose, L-arabinose or L-arabitol.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Xylanolytic transcriptional activator xlnRPRO_0000114989Add
BLAST

Proteomic databases

PaxDbiO42804.

Expressioni

Inductioni

Expressed in presence of xylose.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00012027.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi169 – 1757Poly-Ala

Sequence similaritiesi

Belongs to the xlnR/xlr1 family.Curated
Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IRWS. Eukaryota.
ENOG410YDEK. LUCA.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPSIPQFT SSFSPFSSGS HSTGMAPSQT VGLDTLAEGS QYVLEQLQLS
60 70 80 90 100
RDAAGTGAGD GATSTSLRNS MSHTKDQPPF DNEKNQSTGS GFRDALQRDP
110 120 130 140 150
LVEARSAVRK TSSSAPVRRR ISRACDQCNQ LRTKCDGQHP CAHCIEFGLT
160 170 180 190 200
CEYARERKKR GKASKKDLAA AAAAATQGSN GHSGQANASL MGERTSEDSR
210 220 230 240 250
PGQDVNGTYD SAFESHHLSS QPSHMQHAST AGISGLHESQ TAPSHSQSSL
260 270 280 290 300
GTTIDAMHLN HFNTMNDSGR PAMSISDLRS LPPSVLPPQG LSSGYNASAF
310 320 330 340 350
ALVNPQEPGS PANQFRLGSS AENPTAPFLG LSPPGQSPGW LPLPSPSPAN
360 370 380 390 400
FPSFSLHPFS STLRYPVLQP VLPHIASIIP QSLACDLLDV YFTSSSSSHL
410 420 430 440 450
SPLSPYVVGY IFRKQSFLHP TKPRICSPGL LASMLWVAAQ TSEAAFLTSP
460 470 480 490 500
PSARGRVCQK LLELTIGLLR PLVHGPATGE ASPNYAANMV INGVALGGFG
510 520 530 540 550
VSMDQLGAQS SATGAVDDVA TYVHLATVVS ASEYKAASMR WWTAAWSLAR
560 570 580 590 600
ELKLGRELPP NVSHARQDGE RDGDGEADKR HPPTLITSLG HGSGSSGINV
610 620 630 640 650
TEEEREERRR LWWLLYATDR HLALCYNRPL TLLDKECGGL LQPMNDDLWQ
660 670 680 690 700
VGDFAAAAYR QVGPPVECTG HSMYGYFLPL MTILGGIVDL HHAENHPRFG
710 720 730 740 750
LAFRNSPEWE RQVLDVTRQL DTYGRSLKEF EARYTSNLTL GATDNEPVVE
760 770 780 790 800
GAHLDHTSPS GRSSSTVGSR VSESIVHTRM VVAYGTHIMH VLHILLAGKW
810 820 830 840 850
DPVNLLEDHD LWISSESFVS AMSHAVGAAE AAAEILEYDP DLSFMPFFFG
860 870 880 890 900
IYLLQGSFLL LLAADKLQGD ASPSVVRACE TIVRAHEACV VTLNTEYQRT
910 920 930 940
FRKVMRSALA QVRGRIPEDF GEQQQRRREV LALYRWSGDG SGLAL
Length:945
Mass (Da):102,073
Last modified:March 23, 2010 - v2
Checksum:iFA5C85409EB98602
GO

Sequence cautioni

The sequence CAA05082.1 differs from that shown. Reason: Frameshift at position 12. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001909 Genomic DNA. Translation: CAA05082.1. Frameshift.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001909 Genomic DNA. Translation: CAA05082.1. Frameshift.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00012027.

Proteomic databases

PaxDbiO42804.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IRWS. Eukaryota.
ENOG410YDEK. LUCA.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and analysis of xlnR, encoding a transcriptional activator co-ordinating xylanolytic expression in Aspergillus niger."
    van Peij N.N.M.E., Visser J., De Graaff L.H.
    Mol. Microbiol. 27:131-142(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.
  2. "The transcriptional activator XlnR regulates both xylanolytic and endoglucanase gene expression in Aspergillus niger."
    van Peij N.N., Gielkens M.M., de Vries R.P., Visser J., de Graaff L.H.
    Appl. Environ. Microbiol. 64:3615-3619(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  3. "Two cellobiohydrolase-encoding genes from Aspergillus niger require D-xylose and the xylanolytic transcriptional activator XlnR for their expression."
    Gielkens M.M., Dekkers E., Visser J., de Graaff L.H.
    Appl. Environ. Microbiol. 65:4340-4345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "The Aspergillus niger transcriptional activator XlnR, which is involved in the degradation of the polysaccharides xylan and cellulose, also regulates D-xylose reductase gene expression."
    Hasper A.A., Visser J., de Graaff L.H.
    Mol. Microbiol. 36:193-200(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "EglC, a new endoglucanase from Aspergillus niger with major activity towards xyloglucan."
    Hasper A.A., Dekkers E., van Mil M., van de Vondervoort P.J., de Graaff L.H.
    Appl. Environ. Microbiol. 68:1556-1560(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Regulation of the a-glucuronidase encoding gene (aguA) from Aspergillus niger."
    de Vries R.P., van de Vondervoort P.J.I., Hendriks L., van de Belt M., Visser J.V.
    Mol. Genet. Genomics 268:96-102(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Spatial differentiation in the vegetative mycelium of Aspergillus niger."
    Levin A.M., de Vries R.P., Conesa A., de Bekker C., Talon M., Menke H.H., van Peij N.N., Wosten H.A.
    Eukaryot. Cell 6:2311-2322(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Regulation of pentose catabolic pathway genes of Aspergillus niger."
    de Groot M.J.L., van den Dool C., Woesten H.A.B., Levisson M., vanKuyk P.A., Ruijter G.J.G., de Vries R.P.
    Food Technol. Biotechnol. 45:134-138(2007)
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.
  9. "A trispecies Aspergillus microarray: comparative transcriptomics of three Aspergillus species."
    Andersen M.R., Vongsangnak W., Panagiotou G., Salazar M.P., Lehmann L., Nielsen J.
    Proc. Natl. Acad. Sci. U.S.A. 105:4387-4392(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, FUNCTION.
  10. "Regulation of pentose utilisation by AraR, but not XlnR, differs in Aspergillus nidulans and Aspergillus niger."
    Battaglia E., Hansen S.F., Leendertse A., Madrid S., Mulder H., Nikolaev I., de Vries R.P.
    Appl. Microbiol. Biotechnol. 91:387-397(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.
  11. "Analysis of regulation of pentose utilisation in Aspergillus niger reveals evolutionary adaptations in Eurotiales."
    Battaglia E., Visser L., Nijssen A., van Veluw G.J., Woesten H.A., de Vries R.P.
    Stud. Mycol. 69:31-38(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

Entry informationi

Entry nameiXLNR_ASPNG
AccessioniPrimary (citable) accession number: O42804
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 23, 2010
Last modified: November 11, 2015
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.