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Protein

cAMP-dependent protein kinase regulatory subunit

Gene

PKAR

Organism
Colletotrichum trifolii
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

cAMP-dependent protein kinase PKA regulatory subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei223 – 2231cAMP 1By similarity
Binding sitei232 – 2321cAMP 1By similarity
Binding sitei344 – 3441cAMP 2By similarity
Binding sitei353 – 3531cAMP 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi145 – 276132cAMP 1Add
BLAST
Nucleotide bindingi277 – 398122cAMP 2Add
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase regulatory subunit
Short name:
PKA regulatory subunit
Gene namesi
Name:PKAR
OrganismiColletotrichum trifolii
Taxonomic identifieri5466 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesGlomerellaceaeColletotrichum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404cAMP-dependent protein kinase regulatory subunitPRO_0000205406Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO42794.

Interactioni

Subunit structurei

Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO42794.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 144131Dimerization and phosphorylationSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR012198. cAMP_dep_PK_reg_su.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
[Graphical view]
PIRSFiPIRSF000548. PK_regulatory. 1 hit.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPTYRPVQ CSKLTDHELL RIPHSPSLEP LDYCIEPISY LRRTVYDLHT
60 70 80 90 100
TVANRSSSRA LLHKQPPVMF KSPFGANANP FGGASDGATV GGNAMHQYNF
110 120 130 140 150
SRRTSVSAES LKPSADTYDN WTPPVHDKTN EQLSRLKTAI AGNFLFSHLD
160 170 180 190 200
DEQSAQILGA LIEKPIPAKD IKVISQGDAG EYFYVVEKGS FDVYVNEKGT
210 220 230 240 250
LQPGPEGMGE KVGTIQAGGS FGELALMYNA PRAATVISAE PGCTLWALDR
260 270 280 290 300
LTFRRILMES TFLAAACTRT SSEKFPCCRH SHHMSAQKSP TRWKLRSTPL
310 320 330 340 350
VRRLSRRETR VTRFTCSRWR GRCLPGEMAR ESVKHYSKGD FFGELALLND
360 370 380 390 400
APRAASIVAT TDVKVASLGK SAFQRLLGPV EGIMRRTKYD DIKTGVEEMD

PLQV
Length:404
Mass (Da):44,778
Last modified:June 1, 1998 - v1
Checksum:i4A60317816E3FF04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046922 Genomic DNA. Translation: AAC04356.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046922 Genomic DNA. Translation: AAC04356.1.

3D structure databases

ProteinModelPortaliO42794.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO42794.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR012198. cAMP_dep_PK_reg_su.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
[Graphical view]
PIRSFiPIRSF000548. PK_regulatory. 1 hit.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKAPR_COLTR
AccessioniPrimary (citable) accession number: O42794
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 16, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.