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Protein

Lysophospholipase

Gene

lpl

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase (EC:3.1.1.5)
Alternative name(s):
Phospholipase B
Gene namesi
Name:lpl
ORF Names:5C2.110, NCU03141
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU03141.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002463820 – 653LysophospholipaseAdd BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi298N-linked (GlcNAc...)Sequence analysis1
Glycosylationi328N-linked (GlcNAc...)Sequence analysis1
Glycosylationi365N-linked (GlcNAc...)Sequence analysis1
Glycosylationi407N-linked (GlcNAc...)Sequence analysis1
Glycosylationi459N-linked (GlcNAc...)Sequence analysis1
Glycosylationi476N-linked (GlcNAc...)Sequence analysis1
Glycosylationi507N-linked (GlcNAc...)Sequence analysis1
Glycosylationi533N-linked (GlcNAc...)Sequence analysis1
Glycosylationi561N-linked (GlcNAc...)Sequence analysis1
Glycosylationi602N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO42790.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 606PLA2cPROSITE-ProRule annotationAdd BLAST550

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189547.
InParanoidiO42790.
KOiK13333.
OMAiSVYLNNF.
OrthoDBiEOG092C2IZ9.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLPSSLLIA APLLANVSAE PIRIPQRDVS VVSTSQQLAV RALPDSPSGG
60 70 80 90 100
YAPAVVDCPK TKPTLRKAVD LSNEEKNWLS IRRKNTIQPM RDLLKRANIT
110 120 130 140 150
GFDSETFMNE AANNISQLPN VAIAISGGGY RALMNGAGFV AAADNRIQNT
160 170 180 190 200
TGAGGIGGLL QSSTYLAGLS GGGWLVGSLF SNNFSSIETL LSENKVWDFE
210 220 230 240 250
NSIFKGPKEA GLSTVNRIQY WSEVAKEVAK KKDAGFETSI TDYWGRALSY
260 270 280 290 300
QLIGADMGGP AYTFSSIAQT DNFQKAETPF PILVADGRAP GDTIISLNAT
310 320 330 340 350
NYEFNPFETG SWDPTVYGFA PTKYLGANFS NGVIPSGGKC VEGLDQAGFV
360 370 380 390 400
MGTSSTLFNQ FLLANISSYD GVPDVLIEAV TSVLKEIGAK RDDVSQIIPN
410 420 430 440 450
PFLDWNNRTN PNADTLELDL VDGGEDLQNI PLNPLTQPVR AVDVIFAVDS
460 470 480 490 500
SADVTNWPNG TALRATYERT FGSISNGTLF PSIPDDWTFI NLGLNNRPSF
510 520 530 540 550
FGCDVKNFTL NANQKVPPLI VYVPNAPYTA LSNVSTFDPS YTMSQRNDII
560 570 580 590 600
GNGWNSATQG NGTLDSEWPT CVACAVISRS LDRLGRQTPA ACKTCFERYC
610 620 630 640 650
WNGTVNSKDT GVYMPEFKIA DAHALDSGAV AIGKMVNVWS SVVVGVVAAT

LLL
Length:653
Mass (Da):70,111
Last modified:June 7, 2005 - v2
Checksum:iBF8EFCF1F6515A35
GO

Sequence cautioni

The sequence AAC03053 differs from that shown. Reason: Frameshift at positions 29, 373 and 391.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti45D → N in strain: Lindegren 25a. 1 Publication1
Natural varianti115I → V in strain: Lindegren 25a. 1 Publication1
Natural varianti597E → D in strain: Lindegren 25a. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045574 Genomic DNA. Translation: AAC03052.1. Frameshift.
AF045575 Genomic DNA. Translation: AAC03053.1. Frameshift.
BX842637 Genomic DNA. Translation: CAE76554.1.
CM002236 Genomic DNA. Translation: EAA34954.2.
RefSeqiXP_964190.2. XM_959097.3.

Genome annotation databases

EnsemblFungiiEAA34954; EAA34954; NCU03141.
GeneIDi3880339.
KEGGincr:NCU03141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045574 Genomic DNA. Translation: AAC03052.1. Frameshift.
AF045575 Genomic DNA. Translation: AAC03053.1. Frameshift.
BX842637 Genomic DNA. Translation: CAE76554.1.
CM002236 Genomic DNA. Translation: EAA34954.2.
RefSeqiXP_964190.2. XM_959097.3.

3D structure databases

ProteinModelPortaliO42790.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA34954; EAA34954; NCU03141.
GeneIDi3880339.
KEGGincr:NCU03141.

Organism-specific databases

EuPathDBiFungiDB:NCU03141.

Phylogenomic databases

HOGENOMiHOG000189547.
InParanoidiO42790.
KOiK13333.
OMAiSVYLNNF.
OrthoDBiEOG092C2IZ9.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLB_NEUCR
AccessioniPrimary (citable) accession number: O42790
Secondary accession number(s): O42791, Q6MUU7, Q7RW01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.