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O42790 (PLB_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase

EC=3.1.1.5
Alternative name(s):
Phospholipase B
Gene names
Name:lpl
ORF Names:5C2.110, NCU03141
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length653 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the release of fatty acids from lysophospholipids By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the lysophospholipase family.

Contains 1 PLA2c domain.

Sequence caution

The sequence AAC03053.1 differs from that shown. Reason: Frameshift at positions 29, 373 and 391.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processphospholipid catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 653634Lysophospholipase
PRO_0000024638

Regions

Domain57 – 606550PLA2c

Amino acid modifications

Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1491N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation3281N-linked (GlcNAc...) Potential
Glycosylation3651N-linked (GlcNAc...) Potential
Glycosylation4071N-linked (GlcNAc...) Potential
Glycosylation4591N-linked (GlcNAc...) Potential
Glycosylation4761N-linked (GlcNAc...) Potential
Glycosylation5071N-linked (GlcNAc...) Potential
Glycosylation5331N-linked (GlcNAc...) Potential
Glycosylation5611N-linked (GlcNAc...) Potential
Glycosylation6021N-linked (GlcNAc...) Potential

Natural variations

Natural variant451D → N in strain: Lindegren 25a. Ref.1
Natural variant1151I → V in strain: Lindegren 25a. Ref.1
Natural variant5971E → D in strain: Lindegren 25a. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O42790 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: BF8EFCF1F6515A35

FASTA65370,111
        10         20         30         40         50         60 
MHLPSSLLIA APLLANVSAE PIRIPQRDVS VVSTSQQLAV RALPDSPSGG YAPAVVDCPK 

        70         80         90        100        110        120 
TKPTLRKAVD LSNEEKNWLS IRRKNTIQPM RDLLKRANIT GFDSETFMNE AANNISQLPN 

       130        140        150        160        170        180 
VAIAISGGGY RALMNGAGFV AAADNRIQNT TGAGGIGGLL QSSTYLAGLS GGGWLVGSLF 

       190        200        210        220        230        240 
SNNFSSIETL LSENKVWDFE NSIFKGPKEA GLSTVNRIQY WSEVAKEVAK KKDAGFETSI 

       250        260        270        280        290        300 
TDYWGRALSY QLIGADMGGP AYTFSSIAQT DNFQKAETPF PILVADGRAP GDTIISLNAT 

       310        320        330        340        350        360 
NYEFNPFETG SWDPTVYGFA PTKYLGANFS NGVIPSGGKC VEGLDQAGFV MGTSSTLFNQ 

       370        380        390        400        410        420 
FLLANISSYD GVPDVLIEAV TSVLKEIGAK RDDVSQIIPN PFLDWNNRTN PNADTLELDL 

       430        440        450        460        470        480 
VDGGEDLQNI PLNPLTQPVR AVDVIFAVDS SADVTNWPNG TALRATYERT FGSISNGTLF 

       490        500        510        520        530        540 
PSIPDDWTFI NLGLNNRPSF FGCDVKNFTL NANQKVPPLI VYVPNAPYTA LSNVSTFDPS 

       550        560        570        580        590        600 
YTMSQRNDII GNGWNSATQG NGTLDSEWPT CVACAVISRS LDRLGRQTPA ACKTCFERYC 

       610        620        630        640        650 
WNGTVNSKDT GVYMPEFKIA DAHALDSGAV AIGKMVNVWS SVVVGVVAAT LLL 

« Hide

References

« Hide 'large scale' references
[1]"Polymorphism around cog extends into adjacent structural genes."
Catcheside D.E.A., Yeadon P.J.
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-45; VAL-115 AND ASP-597.
Strain: 74-OR23-1VA / FGSC 2489 and Lindegren 25a.
[2]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF045574 Genomic DNA. Translation: AAC03052.1. Frameshift.
AF045575 Genomic DNA. Translation: AAC03053.1. Frameshift.
BX842637 Genomic DNA. Translation: CAE76554.1.
CM002236 Genomic DNA. Translation: EAA34954.2.
RefSeqXP_964190.2. XM_959097.2.
UniGeneNcr.14976.

3D structure databases

ProteinModelPortalO42790.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU03141.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000002857; EFNCRP00000002857; EFNCRG00000002854.
GeneID3880339.
KEGGncr:NCU03141.

Phylogenomic databases

eggNOGNOG271081.
HOGENOMHOG000189547.
KOK13333.
OMAVYLNNFT.
OrthoDBEOG7N37NC.

Family and domain databases

InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMSSF52151. SSF52151. 1 hit.
PROSITEPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLB_NEUCR
AccessionPrimary (citable) accession number: O42790
Secondary accession number(s): O42791, Q6MUU7, Q7RW01
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 7, 2005
Last modified: February 19, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families