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O42790

- PLB_NEUCR

UniProt

O42790 - PLB_NEUCR

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Protein

Lysophospholipase

Gene

lpl

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase (EC:3.1.1.5)
Alternative name(s):
Phospholipase B
Gene namesi
Name:lpl
ORF Names:5C2.110, NCU03141
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 653634LysophospholipasePRO_0000024638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi507 – 5071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi533 – 5331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi602 – 6021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU03141.1.

Structurei

3D structure databases

ProteinModelPortaliO42790.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 606550PLA2cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG271081.
HOGENOMiHOG000189547.
InParanoidiO42790.
KOiK13333.
OMAiVYLNNFT.
OrthoDBiEOG7N37NC.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42790-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLPSSLLIA APLLANVSAE PIRIPQRDVS VVSTSQQLAV RALPDSPSGG
60 70 80 90 100
YAPAVVDCPK TKPTLRKAVD LSNEEKNWLS IRRKNTIQPM RDLLKRANIT
110 120 130 140 150
GFDSETFMNE AANNISQLPN VAIAISGGGY RALMNGAGFV AAADNRIQNT
160 170 180 190 200
TGAGGIGGLL QSSTYLAGLS GGGWLVGSLF SNNFSSIETL LSENKVWDFE
210 220 230 240 250
NSIFKGPKEA GLSTVNRIQY WSEVAKEVAK KKDAGFETSI TDYWGRALSY
260 270 280 290 300
QLIGADMGGP AYTFSSIAQT DNFQKAETPF PILVADGRAP GDTIISLNAT
310 320 330 340 350
NYEFNPFETG SWDPTVYGFA PTKYLGANFS NGVIPSGGKC VEGLDQAGFV
360 370 380 390 400
MGTSSTLFNQ FLLANISSYD GVPDVLIEAV TSVLKEIGAK RDDVSQIIPN
410 420 430 440 450
PFLDWNNRTN PNADTLELDL VDGGEDLQNI PLNPLTQPVR AVDVIFAVDS
460 470 480 490 500
SADVTNWPNG TALRATYERT FGSISNGTLF PSIPDDWTFI NLGLNNRPSF
510 520 530 540 550
FGCDVKNFTL NANQKVPPLI VYVPNAPYTA LSNVSTFDPS YTMSQRNDII
560 570 580 590 600
GNGWNSATQG NGTLDSEWPT CVACAVISRS LDRLGRQTPA ACKTCFERYC
610 620 630 640 650
WNGTVNSKDT GVYMPEFKIA DAHALDSGAV AIGKMVNVWS SVVVGVVAAT

LLL
Length:653
Mass (Da):70,111
Last modified:June 7, 2005 - v2
Checksum:iBF8EFCF1F6515A35
GO

Sequence cautioni

The sequence AAC03053.1 differs from that shown. Reason: Frameshift at positions 29, 373 and 391. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451D → N in strain: Lindegren 25a. 1 Publication
Natural varianti115 – 1151I → V in strain: Lindegren 25a. 1 Publication
Natural varianti597 – 5971E → D in strain: Lindegren 25a. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045574 Genomic DNA. Translation: AAC03052.1. Frameshift.
AF045575 Genomic DNA. Translation: AAC03053.1. Frameshift.
BX842637 Genomic DNA. Translation: CAE76554.1.
CM002236 Genomic DNA. Translation: EAA34954.2.
RefSeqiXP_964190.2. XM_959097.2.
UniGeneiNcr.14976.

Genome annotation databases

EnsemblFungiiEFNCRT00000002857; EFNCRP00000002857; EFNCRG00000002854.
GeneIDi3880339.
KEGGincr:NCU03141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045574 Genomic DNA. Translation: AAC03052.1 . Frameshift.
AF045575 Genomic DNA. Translation: AAC03053.1 . Frameshift.
BX842637 Genomic DNA. Translation: CAE76554.1 .
CM002236 Genomic DNA. Translation: EAA34954.2 .
RefSeqi XP_964190.2. XM_959097.2.
UniGenei Ncr.14976.

3D structure databases

ProteinModelPortali O42790.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU03141.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000002857 ; EFNCRP00000002857 ; EFNCRG00000002854 .
GeneIDi 3880339.
KEGGi ncr:NCU03141.

Phylogenomic databases

eggNOGi NOG271081.
HOGENOMi HOG000189547.
InParanoidi O42790.
KOi K13333.
OMAi VYLNNFT.
OrthoDBi EOG7N37NC.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Polymorphism around cog extends into adjacent structural genes."
    Catcheside D.E.A., Yeadon P.J.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-45; VAL-115 AND ASP-597.
    Strain: 74-OR23-1VA / FGSC 2489 and Lindegren 25a.
  2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  3. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiPLB_NEUCR
AccessioniPrimary (citable) accession number: O42790
Secondary accession number(s): O42791, Q6MUU7, Q7RW01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 7, 2005
Last modified: October 29, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3