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Protein

Serine/threonine-protein phosphatase 2B catalytic subunit A1

Gene

CNA1

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe3+By similarityNote: Binds 1 Fe3+ ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi120IronBy similarity1
Metal bindingi122IronBy similarity1
Metal bindingi148IronBy similarity1
Metal bindingi148ZincBy similarity1
Metal bindingi180ZincBy similarity1
Active sitei181Proton donorBy similarity1
Metal bindingi229ZincBy similarity1
Metal bindingi311ZincBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCalmodulin-binding, Hydrolase, Protein phosphatase
LigandIron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2B catalytic subunit A1 (EC:3.1.3.16)
Alternative name(s):
Calcineurin A1
Gene namesi
Name:CNA1
ORF Names:CNAG_04796
OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Taxonomic identifieri235443 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000010091 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiFungiDB:CNAG_04796

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588321 – 639Serine/threonine-protein phosphatase 2B catalytic subunit A1Add BLAST639

Proteomic databases

PRIDEiO42773

Interactioni

Subunit structurei

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO42773
SMRiO42773
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

Phylogenomic databases

OrthoDBiEOG092C1CSB

Family and domain databases

Gene3Di3.60.21.10, 2 hits
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

O42773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPATQTAN AIAAINNRSN LVIPEIDFTQ HQLENGEIVS TTERVIKDVQ
60 70 80 90 100
APAMYVPTDD QFWSKVDKTK PDIAFLKNHF YREGRLTEEQ ALYILEKGGE
110 120 130 140 150
LLRSEPNLLE VDAPITVCGD IHGQYYDLMK LFEVGGNPAD TRYLFLGDYV
160 170 180 190 200
DRGYFSIECV LYLWSLKMWY PDTLFLLRGN HECRHLTDYF TFKLECKHKY
210 220 230 240 250
SETVYNACME SFCNLPLAAV MNKQFLCIHG GLSPELHTLD DLRSINRFRE
260 270 280 290 300
PPTQGLMCDI LWADPLEDFG SEKTNENFLH NHVRGCSYFF TYNAACQFLE
310 320 330 340 350
RNNLLSIIRA HEAQDAGYRM YRKTKTTGFP SVMTIFSAPN YLDVYSNKAA
360 370 380 390 400
VLKYESNVMN IRQFNCTPHP YWLPNFMDVF TWSLPFVGEK ITDMLIAILN
410 420 430 440 450
CCTKEELEEE DEEFPLNAPE PTDAESAAER RQIIKNKILA VGRMSRVFSL
460 470 480 490 500
LREESERVSE LKSISGSNAL PAGMLASGAE GIKEAIQGFE DARKSDIENE
510 520 530 540 550
RLPPDIIDPD EDKPASPSAS PIMPATPEEI PSEIPYDSPI TGTPRTPISS
560 570 580 590 600
AIASGSPGSP GTPTSPSIGG PPLTAWRPGH GRRTSLGTTK TSPSTRRRSL
610 620 630
ENTMHLIRDV VGGKDAQGDG QLERLAEVIS SPTKGGQGE
Length:639
Mass (Da):71,500
Last modified:June 1, 1998 - v1
Checksum:i4B92EBE361C80579
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042082 Genomic DNA Translation: AAB97372.1
CP003829 Genomic DNA Translation: AFR97420.1
RefSeqiXP_012052213.1, XM_012196823.1

Genome annotation databases

EnsemblFungiiAFR97420; AFR97420; CNAG_04796
GeneIDi23888175

Similar proteinsi

Entry informationi

Entry nameiPP2B1_CRYNH
AccessioniPrimary (citable) accession number: O42773
Secondary accession number(s): J9W089
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health