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O42773

- PP2B1_CRYNH

UniProt

O42773 - PP2B1_CRYNH

Protein

Serine/threonine-protein phosphatase 2B catalytic subunit A1

Gene

CNA1

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 1 Fe3+ ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201IronBy similarity
    Metal bindingi122 – 1221IronBy similarity
    Metal bindingi148 – 1481IronBy similarity
    Metal bindingi148 – 1481ZincBy similarity
    Metal bindingi180 – 1801ZincBy similarity
    Active sitei181 – 1811Proton donorBy similarity
    Metal bindingi229 – 2291ZincBy similarity
    Metal bindingi311 – 3111ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Calmodulin-binding, Iron, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit A1 (EC:3.1.3.16)
    Alternative name(s):
    Calcineurin A1
    Gene namesi
    Name:CNA1
    ORF Names:CNAG_04796
    OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
    Taxonomic identifieri235443 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
    ProteomesiUP000010091: Chromosome 10

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 639639Serine/threonine-protein phosphatase 2B catalytic subunit A1PRO_0000058832Add
    BLAST

    Interactioni

    Subunit structurei

    Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

    Structurei

    3D structure databases

    ProteinModelPortaliO42773.
    SMRiO42773. Positions 39-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

    Phylogenomic databases

    OrthoDBiEOG77M8X9.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42773-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPATQTAN AIAAINNRSN LVIPEIDFTQ HQLENGEIVS TTERVIKDVQ    50
    APAMYVPTDD QFWSKVDKTK PDIAFLKNHF YREGRLTEEQ ALYILEKGGE 100
    LLRSEPNLLE VDAPITVCGD IHGQYYDLMK LFEVGGNPAD TRYLFLGDYV 150
    DRGYFSIECV LYLWSLKMWY PDTLFLLRGN HECRHLTDYF TFKLECKHKY 200
    SETVYNACME SFCNLPLAAV MNKQFLCIHG GLSPELHTLD DLRSINRFRE 250
    PPTQGLMCDI LWADPLEDFG SEKTNENFLH NHVRGCSYFF TYNAACQFLE 300
    RNNLLSIIRA HEAQDAGYRM YRKTKTTGFP SVMTIFSAPN YLDVYSNKAA 350
    VLKYESNVMN IRQFNCTPHP YWLPNFMDVF TWSLPFVGEK ITDMLIAILN 400
    CCTKEELEEE DEEFPLNAPE PTDAESAAER RQIIKNKILA VGRMSRVFSL 450
    LREESERVSE LKSISGSNAL PAGMLASGAE GIKEAIQGFE DARKSDIENE 500
    RLPPDIIDPD EDKPASPSAS PIMPATPEEI PSEIPYDSPI TGTPRTPISS 550
    AIASGSPGSP GTPTSPSIGG PPLTAWRPGH GRRTSLGTTK TSPSTRRRSL 600
    ENTMHLIRDV VGGKDAQGDG QLERLAEVIS SPTKGGQGE 639
    Length:639
    Mass (Da):71,500
    Last modified:June 1, 1998 - v1
    Checksum:i4B92EBE361C80579
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042082 Genomic DNA. Translation: AAB97372.1.
    CP003829 Genomic DNA. Translation: AFR97420.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042082 Genomic DNA. Translation: AAB97372.1 .
    CP003829 Genomic DNA. Translation: AFR97420.1 .

    3D structure databases

    ProteinModelPortali O42773.
    SMRi O42773. Positions 39-402.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG77M8X9.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Calcineurin is required for virulence of Cryptococcus neoformans."
      Odom A., Muir S., Lim E., Toffaletti D.L., Perfect J.R., Heitman J.
      EMBO J. 16:2576-2589(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: H99 / ATCC 208821 / CBS 10515 / FGSC 9487.
    2. "Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation."
      Janbon G., Ormerod K.L., Paulet D., Byrnes E.J. III, Yadav V., Chatterjee G., Mullapudi N., Hon C.-C., Billmyre R.B., Brunel F., Bahn Y.-S., Chen W., Chen Y., Chow E.W.L., Coppee J.-Y., Floyd-Averette A., Gaillardin C., Gerik K.J.
      , Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L., Hsueh Y.-P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W., Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C., Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q., Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A., Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A., Cuomo C.A., Dietrich F.S.
      PLoS Genet. 10:E1004261-E1004261(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H99 / ATCC 208821 / CBS 10515 / FGSC 9487.

    Entry informationi

    Entry nameiPP2B1_CRYNH
    AccessioniPrimary (citable) accession number: O42773
    Secondary accession number(s): J9W089
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3