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O42772 (SDHB_MYCGR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:SDH2
OrganismMycosphaerella graminicola (Speckled leaf blotch fungus) (Septoria tritici)
Taxonomic identifier1047171 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeCapnodialesMycosphaerellaceaeZymoseptoria

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 297Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000010349

Regions

Domain78 – 157802Fe-2S ferredoxin-type
Domain199 – 229314Fe-4S ferredoxin-type

Sites

Metal binding1171Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1221Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1251Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1371Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding2091Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding2121Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding2151Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding2191Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2661Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2721Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2761Iron-sulfur 2 (4Fe-4S) By similarity
Binding site2241Ubiquinone; shared with DHSD By similarity

Sequences

Sequence LengthMass (Da)Tools
O42772 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: A50010A24F48F6D4

FASTA29733,667
        10         20         30         40         50         60 
MALRLATRRF APIAFRRGMA TTIEHTKEPI SATAEALSAS RPPIKETKTS TVKEPQMDAD 

        70         80         90        100        110        120 
AKTKTFHIYR WNPDQPTDKP RMQSYTLDLN KTGPMMLDAL IRIKNEVDPT LTFRRSCREG 

       130        140        150        160        170        180 
ICGSCAMNID GVNTLACLCR IPTDTAKETR IYPLPHTYVV KDLVPDMTQF YKQYKSIKPY 

       190        200        210        220        230        240 
LQRDTAPPDG KENRQSVADR KKLDGLYECI LCACCSTSCP SYWWNSEEYL GPAVLLQSYR 

       250        260        270        280        290 
WINDSRDEKT AQRKDALNNS MSLYRCHTIL NCSRTCPKGL NPALAIAEIK KSMAFTG 

« Hide

References

[1]"A single amino-acid substitution in the iron-sulphur protein subunit of succinate dehydrogenase determines resistance to carboxin in Mycosphaerella graminicola."
Skinner W., Bailey A.M., Renwick A., Keon J.P.R., Gurr S.J., Hargreaves J.A.
Curr. Genet. 34:393-398(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF042062 Genomic DNA. Translation: AAB97419.1.

3D structure databases

ProteinModelPortalO42772.
SMRO42772. Positions 59-294.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL613815.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OMARERICGS.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_MYCGR
AccessionPrimary (citable) accession number: O42772
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: May 14, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways