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O42772

- SDHB_MYCGR

UniProt

O42772 - SDHB_MYCGR

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Protein
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Gene
SDH2
Organism
Mycosphaerella graminicola (Speckled leaf blotch fungus) (Septoria tritici)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster By similarity.
Binds 1 3Fe-4S cluster By similarity.
Binds 1 4Fe-4S cluster By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi117 – 1171Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi122 – 1221Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi125 – 1251Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi137 – 1371Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi209 – 2091Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi212 – 2121Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi215 – 2151Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi219 – 2191Iron-sulfur 3 (3Fe-4S) By similarity
Binding sitei224 – 2241Ubiquinone; shared with DHSD By similarity
Metal bindingi266 – 2661Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi272 – 2721Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi276 – 2761Iron-sulfur 2 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:SDH2
OrganismiMycosphaerella graminicola (Speckled leaf blotch fungus) (Septoria tritici)
Taxonomic identifieri1047171 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeCapnodialesMycosphaerellaceaeZymoseptoria

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 297Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000010349
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliO42772.
SMRiO42772. Positions 59-294.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 157802Fe-2S ferredoxin-type
Add
BLAST
Domaini199 – 229314Fe-4S ferredoxin-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

OMAiRERICGS.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42772-1 [UniParc]FASTAAdd to Basket

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MALRLATRRF APIAFRRGMA TTIEHTKEPI SATAEALSAS RPPIKETKTS    50
TVKEPQMDAD AKTKTFHIYR WNPDQPTDKP RMQSYTLDLN KTGPMMLDAL 100
IRIKNEVDPT LTFRRSCREG ICGSCAMNID GVNTLACLCR IPTDTAKETR 150
IYPLPHTYVV KDLVPDMTQF YKQYKSIKPY LQRDTAPPDG KENRQSVADR 200
KKLDGLYECI LCACCSTSCP SYWWNSEEYL GPAVLLQSYR WINDSRDEKT 250
AQRKDALNNS MSLYRCHTIL NCSRTCPKGL NPALAIAEIK KSMAFTG 297
Length:297
Mass (Da):33,667
Last modified:June 1, 1998 - v1
Checksum:iA50010A24F48F6D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042062 Genomic DNA. Translation: AAB97419.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042062 Genomic DNA. Translation: AAB97419.1 .

3D structure databases

ProteinModelPortali O42772.
SMRi O42772. Positions 59-294.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL613815.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OMAi RERICGS.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A single amino-acid substitution in the iron-sulphur protein subunit of succinate dehydrogenase determines resistance to carboxin in Mycosphaerella graminicola."
    Skinner W., Bailey A.M., Renwick A., Keon J.P.R., Gurr S.J., Hargreaves J.A.
    Curr. Genet. 34:393-398(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSDHB_MYCGR
AccessioniPrimary (citable) accession number: O42772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: May 14, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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