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O42772

- SDHB_MYCGR

UniProt

O42772 - SDHB_MYCGR

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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

SDH2

Organism
Mycosphaerella graminicola (Speckled leaf blotch fungus) (Septoria tritici)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster.By similarity
Binds 1 3Fe-4S cluster.By similarity
Binds 1 4Fe-4S cluster.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi117 – 1171Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi122 – 1221Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi125 – 1251Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi137 – 1371Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi209 – 2091Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi212 – 2121Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi215 – 2151Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi219 – 2191Iron-sulfur 3 (3Fe-4S)By similarity
Binding sitei224 – 2241Ubiquinone; shared with DHSDBy similarity
Metal bindingi266 – 2661Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi272 – 2721Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi276 – 2761Iron-sulfur 2 (4Fe-4S)By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:SDH2
OrganismiMycosphaerella graminicola (Speckled leaf blotch fungus) (Septoria tritici)
Taxonomic identifieri1047171 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeCapnodialesMycosphaerellaceaeZymoseptoria

Subcellular locationi

Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 297Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000010349
Transit peptidei1 – ?MitochondrionSequence Analysis

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliO42772.
SMRiO42772. Positions 59-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 157802Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST
Domaini199 – 229314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

OMAiRERICGS.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42772-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALRLATRRF APIAFRRGMA TTIEHTKEPI SATAEALSAS RPPIKETKTS
60 70 80 90 100
TVKEPQMDAD AKTKTFHIYR WNPDQPTDKP RMQSYTLDLN KTGPMMLDAL
110 120 130 140 150
IRIKNEVDPT LTFRRSCREG ICGSCAMNID GVNTLACLCR IPTDTAKETR
160 170 180 190 200
IYPLPHTYVV KDLVPDMTQF YKQYKSIKPY LQRDTAPPDG KENRQSVADR
210 220 230 240 250
KKLDGLYECI LCACCSTSCP SYWWNSEEYL GPAVLLQSYR WINDSRDEKT
260 270 280 290
AQRKDALNNS MSLYRCHTIL NCSRTCPKGL NPALAIAEIK KSMAFTG
Length:297
Mass (Da):33,667
Last modified:June 1, 1998 - v1
Checksum:iA50010A24F48F6D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042062 Genomic DNA. Translation: AAB97419.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042062 Genomic DNA. Translation: AAB97419.1 .

3D structure databases

ProteinModelPortali O42772.
SMRi O42772. Positions 59-294.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL613815.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OMAi RERICGS.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A single amino-acid substitution in the iron-sulphur protein subunit of succinate dehydrogenase determines resistance to carboxin in Mycosphaerella graminicola."
    Skinner W., Bailey A.M., Renwick A., Keon J.P.R., Gurr S.J., Hargreaves J.A.
    Curr. Genet. 34:393-398(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSDHB_MYCGR
AccessioniPrimary (citable) accession number: O42772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3