ID   HPPD_MYCGR              Reviewed;         419 AA.
AC   O42764;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   16-JUN-2009, entry version 45.
DE   RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE            Short=HPPDase;
DE            Short=4HPPD;
DE            Short=HPD;
DE            EC=1.13.11.27;
GN   Name=HPPD;
OS   Mycosphaerella graminicola (Septoria tritici).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Dothideomycetes; Dothideomycetidae; Capnodiales; Mycosphaerellaceae;
OC   Mycosphaerella.
OX   NCBI_TaxID=54734;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LAST93;
RX   PubMed=9570125; DOI=10.1111/j.1574-6968.1998.tb12966.x;
RA   Keon J.P.R., Hargreaves J.A.;
RT   "Isolation and heterologous expression of a gene encoding 4-
RT   hydroxyphenylpyruvate dioxygenase from the wheat leaf-spot pathogen,
RT   Mycosphaerella graminicola.";
RL   FEMS Microbiol. Lett. 161:337-343(1998).
CC   -!- CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O(2) = homogentisate
CC       + CO(2).
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
CC   -!- SIMILARITY: Belongs to the 4HPPD family.
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DR   EMBL; AF038152; AAC15884.1; -; Genomic_DNA.
DR   HSSP; P80064; 1CJX.
DR   BRENDA; 1.13.11.27; 279360.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR004360; Glyas_bleo-R_dOase.
DR   PANTHER; PTHR11959; HPP_dOase; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   TIGRFAMs; TIGR01263; 4HPPD; 1.
PE   3: Inferred from homology;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    419       4-hydroxyphenylpyruvate dioxygenase.
FT                                /FTId=PRO_0000088405.
FT   METAL       221    221       Iron (By similarity).
FT   METAL       304    304       Iron (By similarity).
FT   METAL       387    387       Iron (By similarity).
SQ   SEQUENCE   419 AA;  46740 MW;  07951CCE0CB50EE3 CRC64;
     MAPGALLVTS QNGRTSPLYD SDGYVPAPAA LVVGGEVNYR GYHHAEWWVG NAKQVAQFYI
     TRMGFEPVAH KGLETGSRFF ASHVVQNNGV RFVFTSPVRS SARQTLKAAP LADQARLDEM
     YDHLDKHGDG VKDVAFEVDD VLAVYENAVA NGAESVSSPH TDSCDEGDVI SAAIKTYGDT
     THTFIQRTTY TGPFLPGYRS CTTVDSANKF LPPVNLEAID HCVGNQDWDE MSDACDFYER
     CLGFHRFWSV DDKDICTEFS ALKSIVMSSP NQVVKMPINE PAHGKKKSQI EEYVDFYNGP
     GVQHIALRTP NIIEAVSNLR SRGVEFISVP DTYYENMRLR LKAAGMKLEE SFDIIQKLNI
     LIDFDEGGYL LQLFTKPLMD RPTVFIEIIQ RNNFDGFGAG NFKSLFEAIE REQDLRGNL
//