Reviewed, UniProtKB/Swiss-Prot O42764 (HPPD_MYCGR)

Names and origin

Protein names

Recommended name:
    4-hydroxyphenylpyruvate dioxygenase
      Short name=HPPDase
      Short name=4HPPD
      Short name=HPD
    EC=1.13.11.27

Gene names

Name:

HPPD

Organism

Mycosphaerella graminicola (Septoria tritici)

Taxonomic identifier

54734 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Dothideomycetidae › Capnodiales › Mycosphaerellaceae › Mycosphaerella

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	4-hydroxyphenylpyruvate dioxygenase		PRO_0000088405
Sites
	Metal binding	221	1	Iron By similarity
	Metal binding	304	1	Iron By similarity
	Metal binding	387	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	O42764-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 07951CCE0CB50EE3	FASTA	419	46,740
	10 20 30 40 50 60 MAPGALLVTS QNGRTSPLYD SDGYVPAPAA LVVGGEVNYR GYHHAEWWVG NAKQVAQFYI 70 80 90 100 110 120 TRMGFEPVAH KGLETGSRFF ASHVVQNNGV RFVFTSPVRS SARQTLKAAP LADQARLDEM 130 140 150 160 170 180 YDHLDKHGDG VKDVAFEVDD VLAVYENAVA NGAESVSSPH TDSCDEGDVI SAAIKTYGDT 190 200 210 220 230 240 THTFIQRTTY TGPFLPGYRS CTTVDSANKF LPPVNLEAID HCVGNQDWDE MSDACDFYER 250 260 270 280 290 300 CLGFHRFWSV DDKDICTEFS ALKSIVMSSP NQVVKMPINE PAHGKKKSQI EEYVDFYNGP 310 320 330 340 350 360 GVQHIALRTP NIIEAVSNLR SRGVEFISVP DTYYENMRLR LKAAGMKLEE SFDIIQKLNI 370 380 390 400 410 LIDFDEGGYL LQLFTKPLMD RPTVFIEIIQ RNNFDGFGAG NFKSLFEAIE REQDLRGNL

References

[1]

"Isolation and heterologous expression of a gene encoding 4-hydroxyphenylpyruvate dioxygenase from the wheat leaf-spot pathogen, Mycosphaerella graminicola." Keon J.P.R., Hargreaves J.A. FEMS Microbiol. Lett. 161:337-343(1998) [PubMed: 9570125] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LAST93.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF038152 Genomic DNA. Translation: AAC15884.1.
3D structure databases
HSSP	HSSP built from PDB template 1CJX based on UniProtKB P80064.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.13.11.27. 279360.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_bleo-R_dOase. [Graphical view]
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD_MYCGR

Accession

Primary (citable) accession number: O42764

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	June 1, 1998
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)