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Protein

DNA helicase

Gene

nimQ

Organism
Emericella nidulans (Aspergillus nidulans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase

Keywords - Biological processi

DNA replicationSAAS annotation

Keywords - Ligandi

ATP-binding, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
Gene namesi
Name:nimQImported
OrganismiEmericella nidulans (Aspergillus nidulans)Imported
Taxonomic identifieri162425 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00009214.

Structurei

3D structure databases

ProteinModelPortaliO42723.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini482 – 688207MCMInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MCM family.UniRule annotationSAAS annotation
Contains MCM domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0477. Eukaryota.
COG1241. LUCA.

Family and domain databases

Gene3Di2.40.50.140. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR031327. MCM.
IPR008045. MCM2.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11630:SF44. PTHR11630:SF44. 2 hits.
PfamiPF00493. MCM. 1 hit.
PF12619. MCM2_N. 1 hit.
PF14551. MCM_N. 1 hit.
[Graphical view]
PRINTSiPR01657. MCMFAMILY.
PR01658. MCMPROTEIN2.
SMARTiSM00350. MCM. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42723-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPLRQSTS AANRGLGNLN RRKRSREPDD DASSVVPPSS PPPSSPPMLP
60 70 80 90 100
FDEDEDEPDE EAELDIDDIE EMAEDEDGID LFGDTFERDY RGGKDDRYRH
110 120 130 140 150
DTLTTMSKKK STLVPDESWR LAWIEEIENL LGRRMPAAFL QDDEDGDIDL
160 170 180 190 200
TAQPRRRRHA YDEDRDDIEM ADDGLEELSL EELVDIKSSN ITDWVTQPQV
210 220 230 240 250
LRSIYREFKA FLTEFTDPTG SSVYGNKIKT LGEVNSASLE VSYTHLSSTK
260 270 280 290 300
AVLGYFLANE PTEVLKVFDQ VALDVTLFHY PQYHDIHNEI HVRITDLPIV
310 320 330 340 350
YTLRQLRQSH LNCLVRVSGV VTRRTGVFPQ LKYVMFICQK CNMTLGPYQQ
360 370 380 390 400
ESSSEVKVTM CQNCQSRGPF TVSSEKTVYR NYQKLTLQES PGSVPAGRLP
410 420 430 440 450
RQREVILLAD LIDSAKPGDE IEITGIYRNS YDAQLNNKNG FPVFATIIEA
460 470 480 490 500
NHVIKSHDQQ AGFQLTEEDE REIRALSRDP DIVEKIIRSI APSIYGHQDV
510 520 530 540 550
KTAVALSLFG GVRKETQGKM SIRGDINVLL LGDPGTAKSQ ILKYVEKTAH
560 570 580 590 600
RAVFATGQGA SAVGLTASVR RDPLTSEWTL EGGALVLADR GTCLIDEFDK
610 620 630 640 650
MNDQDRTSIH EAMEQQTISI SKAGIVTTLQ ARCAVVAAAN PIGGRYNSSA
660 670 680 690 700
PFSENVQLTE PILSRFDILC VVRDLVDPSE DERLASFVIE SHHRANPSKP
710 720 730 740 750
LRDEHGNLIN ADGERIDEEG YRIDDDGIRL PLRPDEIEAR NAARDNDDEK
760 770 780 790 800
EGEIPQELLR KYILYAREHC RPKLYQIDQD KVARLFADMR RESLATGAYP
810 820 830 840 850
ITVRHLEAIM RIAEAFCKMR LSEYCSAQDI DRAIAVTVDS FIGSQKVSAK
860 870 880
RALSRAFAKY TLSRPKPQSK RRAGIPAPVS FERRPQAAR
Length:889
Mass (Da):99,968
Last modified:June 1, 1998 - v1
Checksum:i62BDA1118DDB5281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014813 mRNA. Translation: AAB94861.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014813 mRNA. Translation: AAB94861.1.

3D structure databases

ProteinModelPortaliO42723.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00009214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0477. Eukaryota.
COG1241. LUCA.

Family and domain databases

Gene3Di2.40.50.140. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR031327. MCM.
IPR008045. MCM2.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11630:SF44. PTHR11630:SF44. 2 hits.
PfamiPF00493. MCM. 1 hit.
PF12619. MCM2_N. 1 hit.
PF14551. MCM_N. 1 hit.
[Graphical view]
PRINTSiPR01657. MCMFAMILY.
PR01658. MCMPROTEIN2.
SMARTiSM00350. MCM. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Proteolysis and tyrosine phosphorylation of p34cdc2/cyclin B. The role of MCM2 and initiation of DNA replication to allow tyrosine phosphorylation of p34cdc2."
    Ye X.S., Fincher R.R., Tang A., McNeal K.K., Gygax S.E., Wexler A.N., Ryan K.B., James S.W., Osmani S.A.
    J. Biol. Chem. 272:33384-33393(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: R153Imported.

Entry informationi

Entry nameiO42723_EMEND
AccessioniPrimary (citable) accession number: O42723
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.