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Protein

Transaldolase

Gene

tal1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.By similarity

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (tal1)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321Schiff-base intermediate with substrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pentose shunt

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiR-SPO-163754. Insulin effects increased synthesis of Xylulose-5-Phosphate.
R-SPO-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:tal1
ORF Names:SPCC1020.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1020.06c.
PomBaseiSPCC1020.06c. tal1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322TransaldolasePRO_0000173573Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei268 – 2681Phosphoserine1 Publication
Modified residuei269 – 2691Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO42700.
PRIDEiO42700.

PTM databases

iPTMnetiO42700.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi275551. 36 interactions.
MINTiMINT-4673343.

Structurei

3D structure databases

ProteinModelPortaliO42700.
SMRiO42700. Positions 2-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000281234.
InParanoidiO42700.
KOiK00616.
OMAiFRNIDEI.
OrthoDBiEOG092C3F92.
PhylomeDBiO42700.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLEQLKAT GTVVVSDTGD FESIAKYKPQ DATTNPSLIL AASKKPQYAA
60 70 80 90 100
LVDAAVDYAK AKGGSINSQI EIAFDRLLIE FGTKILAIVP GRVSTEVDAR
110 120 130 140 150
YSFDTQTTIE KARHLIKLYE AEGIGRERVL IKIASTYEGI QAAKQLEEEG
160 170 180 190 200
IHCNLTLLFS FVQAVACAEA NVTLISPFVG RILDFYKAKN NRDYTAQEDP
210 220 230 240 250
GVVSVSNIFN YYKKFGYKTI VMGASFRNVG EIKELAGVDF LTISPALLEQ
260 270 280 290 300
LNNSTDAVPK KLDASKASSL NLEKVSYLTD EPKFRFDFNN DEMAVVKLST
310 320
GIAAFAKDAD TLRTILKAKL EA
Length:322
Mass (Da):35,238
Last modified:November 1, 1998 - v2
Checksum:i0807DC610EEB2E7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA18994.1.
AB010049 mRNA. Translation: BAA24182.1.
PIRiT40834.
T43308.
RefSeqiNP_587953.1. NM_001022944.2.

Genome annotation databases

EnsemblFungiiSPCC1020.06c.1; SPCC1020.06c.1:pep; SPCC1020.06c.
GeneIDi2538977.
KEGGispo:SPCC1020.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA18994.1.
AB010049 mRNA. Translation: BAA24182.1.
PIRiT40834.
T43308.
RefSeqiNP_587953.1. NM_001022944.2.

3D structure databases

ProteinModelPortaliO42700.
SMRiO42700. Positions 2-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275551. 36 interactions.
MINTiMINT-4673343.

PTM databases

iPTMnetiO42700.

Proteomic databases

MaxQBiO42700.
PRIDEiO42700.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1020.06c.1; SPCC1020.06c.1:pep; SPCC1020.06c.
GeneIDi2538977.
KEGGispo:SPCC1020.06c.

Organism-specific databases

EuPathDBiFungiDB:SPCC1020.06c.
PomBaseiSPCC1020.06c. tal1.

Phylogenomic databases

HOGENOMiHOG000281234.
InParanoidiO42700.
KOiK00616.
OMAiFRNIDEI.
OrthoDBiEOG092C3F92.
PhylomeDBiO42700.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.
ReactomeiR-SPO-163754. Insulin effects increased synthesis of Xylulose-5-Phosphate.
R-SPO-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

PROiO42700.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAL1_SCHPO
AccessioniPrimary (citable) accession number: O42700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.