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Protein

Tetratricopeptide repeat protein 1

Gene

tpr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in promoting potassiumm ion uptake.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Protein family/group databases

TCDBi8.A.13.1.1. the tetratricopeptide repeat (tpr1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 1
Gene namesi
Name:tpr1
ORF Names:SPAC27D7.14c, SPAC637.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC27D7.14c.
PomBaseiSPAC27D7.14c. tpr1.

Subcellular locationi

GO - Cellular componenti

  • Cdc73/Paf1 complex Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10391039Tetratricopeptide repeat protein 1PRO_0000106375Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei930 – 9301Phosphoserine1 Publication
Modified residuei932 – 9321Phosphoserine1 Publication
Modified residuei959 – 9591Phosphoserine1 Publication
Modified residuei961 – 9611Phosphoserine1 Publication
Modified residuei964 – 9641Phosphoserine1 Publication
Modified residuei998 – 9981Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO42668.

PTM databases

iPTMnetiO42668.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278554. 14 interactions.
MINTiMINT-4673313.

Structurei

3D structure databases

ProteinModelPortaliO42668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 8434TPR 1Add
BLAST
Repeati175 – 20834TPR 2Add
BLAST
Repeati210 – 24334TPR 3Add
BLAST
Repeati251 – 28838TPR 4Add
BLAST
Repeati326 – 35934TPR 5Add
BLAST
Repeati361 – 39333TPR 6Add
BLAST
Repeati437 – 46933TPR 7Add
BLAST
Repeati514 – 54734TPR 8Add
BLAST
Repeati634 – 66734TPR 9Add
BLAST
Repeati701 – 73434TPR 10Add
BLAST
Repeati737 – 77034TPR 11Add
BLAST
Repeati799 – 83234TPR 12Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili838 – 92992Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 12 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

InParanoidiO42668.
KOiK15176.
OMAiELAYTEG.
OrthoDBiEOG092C0EHT.
PhylomeDBiO42668.

Family and domain databases

Gene3Di1.25.40.10. 5 hits.
InterProiIPR031101. Ctr9.
IPR016137. RGS.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR14027:SF2. PTHR14027:SF2. 1 hit.
PfamiPF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 10 hits.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF48452. SSF48452. 5 hits.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGFTLETHA SRIIEVPLLG QEDQSVEIDC SSLPSDATEL CEILVNEQAP
60 70 80 90 100
REFWTKFAHE YYIRGLREQA ILILKSGLET LKDSESLCIL NANIAAIYLS
110 120 130 140 150
MAREAMLKKD TDLRDEQLRN VRTYLEAANN IDSKSEINVL LHGIYRILLN
160 170 180 190 200
PTDKESLENA ARCFDFVLQK SGGNILGFLG KARILYAKGN YRSALKLYQR
210 220 230 240 250
ALVSNPQFKP DPRIGIGLCF WNLDMKTDAL SAWTRVQQLD PKNTVVDTYI
260 270 280 290 300
GLYYYDLAFQ NVNNDSFVQN YGKALQHIQR AFKTRNNDPV ASSILERYVY
310 320 330 340 350
SKKNYEGCIK LAENVIQNSF SSSLIADGYY WMGRAYHQMG NNEKAMASYQ
360 370 380 390 400
KAKAADDRHL LSSVGIGQIQ ILQNDLTSAK LTFERIAEQN QSCFEALVVL
410 420 430 440 450
GCLHASDSKP DLTKARMLLD RAFNLVGSSK LPRVVDSDLY ITQARLWEKE
460 470 480 490 500
DTKKSLGFLT RALDFLESAH MSVGPELLNN IAVLQYHLGL IPEAHGNIIK
510 520 530 540 550
AKSVLPDANP ELSLLLDYNL ARCEEELGNT SVASEAYVSI LEKHPSFIDA
560 570 580 590 600
RIRKCLLQLS NPNEETFKEI RHIMNADSQN LEVRAFFGWY LSKQKRRPVE
610 620 630 640 650
DPEVRHCSQT LRHWHDDIYS LVQLGNAYMR QAREFRVHND REKLKRQKLY
660 670 680 690 700
IKAIQSYDQA IKFDPKNAHA AQGIAIILAQ NRQFSKALLI LSKVREAIKD
710 720 730 740 750
ATTLINIGNC LAELKQFSRA IEVFETVYSS TGESDTYGVL SCLGRVWLQR
760 770 780 790 800
GRESKNVDYL KESVRYATLA LEKNPENPSL LFNVAFVQFQ LCELIRQKPE
810 820 830 840 850
NSRTVEDLNF AMQQLDASIE TFTKLVSVEH PPYSPTSIEQ RAKMAKNTTK
860 870 880 890 900
RQLERAIQAQ IEYEKSVAAK LEDARIQREK EKARRLAEEE ALLKEKQERE
910 920 930 940 950
RQLQEERQKM QEEVLEWRKS QQKASEDDMS LSDDEEKQSG KKKKKDRKKR
960 970 980 990 1000
KSKSKQESSD SGVSEDDEIP LSDARNKTKK RRVNRRVISE EYTFDQDSDA
1010 1020 1030
EGNQEEEVSR TIEEKQDNDI TDNQDDNKEL NLFSEEDEE
Length:1,039
Mass (Da):119,151
Last modified:June 1, 1998 - v1
Checksum:i81363F2E45C391BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1274YLEA → NLGG in AAC03120 (PubMed:10471809).Curated
Sequence conflicti195 – 1962LK → FR in AAC03120 (PubMed:10471809).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047464 mRNA. Translation: AAC03120.1.
CU329670 Genomic DNA. Translation: CAA15833.1.
PIRiT38447.
T43678.
RefSeqiNP_594620.1. NM_001020048.2.

Genome annotation databases

EnsemblFungiiSPAC27D7.14c.1; SPAC27D7.14c.1:pep; SPAC27D7.14c.
GeneIDi2542077.
KEGGispo:SPAC27D7.14c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047464 mRNA. Translation: AAC03120.1.
CU329670 Genomic DNA. Translation: CAA15833.1.
PIRiT38447.
T43678.
RefSeqiNP_594620.1. NM_001020048.2.

3D structure databases

ProteinModelPortaliO42668.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278554. 14 interactions.
MINTiMINT-4673313.

Protein family/group databases

TCDBi8.A.13.1.1. the tetratricopeptide repeat (tpr1) family.

PTM databases

iPTMnetiO42668.

Proteomic databases

MaxQBiO42668.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC27D7.14c.1; SPAC27D7.14c.1:pep; SPAC27D7.14c.
GeneIDi2542077.
KEGGispo:SPAC27D7.14c.

Organism-specific databases

EuPathDBiFungiDB:SPAC27D7.14c.
PomBaseiSPAC27D7.14c. tpr1.

Phylogenomic databases

InParanoidiO42668.
KOiK15176.
OMAiELAYTEG.
OrthoDBiEOG092C0EHT.
PhylomeDBiO42668.

Miscellaneous databases

PROiO42668.

Family and domain databases

Gene3Di1.25.40.10. 5 hits.
InterProiIPR031101. Ctr9.
IPR016137. RGS.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR14027:SF2. PTHR14027:SF2. 1 hit.
PfamiPF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 10 hits.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF48452. SSF48452. 5 hits.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPR1_SCHPO
AccessioniPrimary (citable) accession number: O42668
Secondary accession number(s): O42796
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.