O42658 (PHS_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pterin-4-alpha-carbinolamine dehydratase
Short name=PHS
EC=4.2.1.96

Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase
Overlapping meiotic transcript 2
Pterin carbinolamine dehydratase
Short name=PCD

Gene names

Name:	omt2
ORF Names:	SPAC27D7.04

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	96 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has a role in spore wall formation. Ref.1
Catalytic activity	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.
Subcellular location	Spore wall. Note: Inner spore wall. Ref.1
Sequence similarities	Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ascospore wall assembly Inferred from mutant phenotype. Source: GeneDB_Spombe tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	ascospore wall Inferred from direct assay. Source: GeneDB_Spombe cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 96	96	Pterin-4-alpha-carbinolamine dehydratase		PRO_0000063063

Sequences

	Sequence		Length	Mass (Da)
	O42658 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 09113B5FB3DF9F4F	FASTA	96	11,101
	10 20 30 40 50 60 MNTSARLLAL VSKSKNNWIL QQGDTKLFKS FRFKNFIEAW GFMSCVALRA QQLNHHPEWT 70 80 90 NVYNKVDITL TTHDTKGLTE KDLKLAEFID TLAKDN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Overlapping omt1+ and omt2+ genes are required for spore wall maturation in Schizosaccharomyces pombe." Kakihara Y., Nabeshima K., Hirata A., Nojima H. Genes Cells 8:547-558(2003) [PubMed: 12786945] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329670 Genomic DNA. Translation: CAA15823.1.
PIR	T38437.
RefSeq	NP_594610.1. NM_001020038.3.
3D structure databases
ProteinModelPortal	O42658.
SMR	O42658. Positions 27-93.
ModBase	Search...
Protein-protein interaction databases
STRING	O42658.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC27D7.04.1; SPAC27D7.04.1:pep; SPAC27D7.04.
GeneID	2541617.
GenomeReviews	Gene locus omt2 in contig CU329670_GR.
KEGG	spo:SPAC27D7.04.
NMPDR	fig|4896.1.peg.4580.
Organism-specific databases
GeneDB_Spombe	SPAC27D7.04.
Phylogenomic databases
eggNOG	fuNOG13403.
GeneTree	EFGT00050000000975.
HOGENOM	HBG705804.
OMA	DWEEREN.
OrthoDB	EOG45MRG1.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-002702-MONOMER.
Gene expression databases
ArrayExpress	O42658.
Family and domain databases
InterPro	IPR001533. Trans/pterin_deHydtase. [Graphical view]
Gene3D	G3DSA:3.30.1360.20. Trans_pterinDh. 1 hit.
KO	K01724.
PANTHER	PTHR12599. Trans_pterinDh. 1 hit.
Pfam	PF01329. Pterin_4a. 1 hit. [Graphical view]
SUPFAM	SSF55248. Trans_pterinDh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PHS_SCHPO

Accession

Primary (citable) accession number: O42658

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	June 1, 1998
Last modified:	December 14, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program