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Protein

Aspartate aminotransferase, cytoplasmic

Gene

aat2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a key role in amino acid metabolism.By similarity

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.Curated

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.By similarity

Cofactori

pyridoxal 5'-phosphateBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38Aspartate; via amide nitrogenBy similarity1
Binding sitei138AspartateBy similarity1
Binding sitei191AspartateBy similarity1
Binding sitei383AspartateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-SPO-70263 Gluconeogenesis
R-SPO-70614 Amino acid synthesis and interconversion (transamination)

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase, cytoplasmic (EC:2.6.1.1)
Alternative name(s):
Transaminase A
Gene namesi
Name:aat2By similarity
ORF Names:SPAC10F6.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC10F6.13c
PomBaseiSPAC10F6.13c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003094512 – 409Aspartate aminotransferase, cytoplasmicBy similarityAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei255N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei385PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO42652
PaxDbiO42652
PRIDEiO42652

PTM databases

iPTMnetiO42652

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi279456, 57 interactors
STRINGi4896.SPAC10F6.13c.1

Structurei

3D structure databases

ProteinModelPortaliO42652
SMRiO42652
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000185898
InParanoidiO42652
KOiK14454
OMAiELFKEWT
OrthoDBiEOG092C2B7X
PhylomeDBiO42652

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR000796 Asp_trans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11879 PTHR11879, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PRINTSiPR00799 TRANSAMINASE
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYGFANIE EAKADAIFKL NAQYHQDEDP KKVNMSVGAY RDDTGKPWIL
60 70 80 90 100
PAVKKASKIV EEQASFNHEY LPIAGLPRFT KAAAEVLFRP NPHLLSEDRV
110 120 130 140 150
ASMQSVSGTG ANFLAASFIE TFYVKHTGAH VYISNPTWPV HRTLWEKLGV
160 170 180 190 200
TVDTYPYWDA KNRSFDYEGM LSTIKSAPEG SIFLLHACAH NPTGIDPTRE
210 220 230 240 250
QWLSIFESLL SRKHLVVFDI AYQGFASGDL NRDSWALNEF VKYNKDFFVC
260 270 280 290 300
QSFAKNMGLY GERTGCMHYV AKDASTKNKV LSQLCIVQRN TISNPPAYGA
310 320 330 340 350
RIAAEILNSP QLFAEWEQDL KTMSSRIIEM RKRLRDSLVA LKTPGSWDHI
360 370 380 390 400
TQQIGMFSFT GLTPAQVQFC QERYHLYFSA NGRISMAGLN NSNVEHVAQA

FNHAVRELP
Length:409
Mass (Da):46,140
Last modified:June 1, 1998 - v1
Checksum:i6CE10FFCC18D3E4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA15726.1
PIRiT37507
RefSeqiNP_593264.1, NM_001018661.2

Genome annotation databases

EnsemblFungiiSPAC10F6.13c.1; SPAC10F6.13c.1:pep; SPAC10F6.13c
GeneIDi2543020
KEGGispo:SPAC10F6.13c

Similar proteinsi

Entry informationi

Entry nameiAATC_SCHPO
AccessioniPrimary (citable) accession number: O42652
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health