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Protein

Serine/threonine-protein kinase rio1

Gene

rio1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the final endonucleolytic cleavage at site D converting 20S pre-rRNA into the mature 18S rRNA.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei148 – 1481ATPBy similarity
Active sitei265 – 2651Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi126 – 1349ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase rio1 (EC:2.7.11.1)
Gene namesi
Name:rio1
ORF Names:SPAC10F6.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC10F6.10.
PomBaseiSPAC10F6.10. rio1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Serine/threonine-protein kinase rio1PRO_0000317085Add
BLAST

Proteomic databases

MaxQBiO42650.

Interactioni

Protein-protein interaction databases

MINTiMINT-4673164.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini120 – 415296Protein kinaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi443 – 49755Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Phylogenomic databases

HOGENOMiHOG000166501.
InParanoidiO42650.
KOiK07178.
OMAiVEPDHPR.
OrthoDBiEOG7WDNCV.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017407. Ser/Thr_kinase_Rio1.
[Graphical view]
PANTHERiPTHR10593:SF23. PTHR10593:SF23. 1 hit.
PIRSFiPIRSF038147. Ser/Thr_PK_RIO1. 1 hit.
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00109. PROTEIN_KINASE_TYR. 1 hit.
PS01245. RIO1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEELKNDAQ TNEEESEYSD FSDGSDNDYF REDDIDWNQA SSNYSARQEN
60 70 80 90 100
FGNNSSKINS VNDHVSTLSR YVNNIKLNDR FEAEDKSSIK DKSDRATSEQ
110 120 130 140 150
VLDPRTRMIL LKLINNGTIS EINGCISTGK EANVYHATNE DGKHFAIKIY
160 170 180 190 200
KTSILVFKDR DRYVSGEFRF RHGYNKRNPR KMVRLWAEKE IRNLKRVAAA
210 220 230 240 250
GIPCPEPILL KQHVLLMSFL GDKKGWAYPK LKDIDMTPGE ATKLYQLVAR
260 270 280 290 300
NMRILFHVCH LVHADLSEYN LLYHKGKVYF IDVSQSVEHD HPQSIDFLRM
310 320 330 340 350
DILNISTFFR RLNAGCLSLP QLFKFITEEG SCEKEAMKTR LNAIYEEEPT
360 370 380 390 400
TEEYEEEFLK TYVPRTLDEV YDIDRDTEIV NAGGVNSLVY KHLLNTDFQK
410 420 430 440 450
LDLNDTTKNQ NDQILPNETS ESDDDANSIS SMENEEERTS DSKSSAKQGK
460 470 480 490
GNGRAKETPE EKRARKKKTK EDKAEKRKSK IPKYEKKRKL KQSGRKK
Length:497
Mass (Da):57,498
Last modified:February 22, 2012 - v2
Checksum:i915DF9F7264CE8DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA15723.2.
PIRiT37504.
RefSeqiNP_593261.2. NM_001018658.2.

Genome annotation databases

EnsemblFungiiSPAC10F6.10.1; SPAC10F6.10.1:pep; SPAC10F6.10.
GeneIDi2542923.
KEGGispo:SPAC10F6.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA15723.2.
PIRiT37504.
RefSeqiNP_593261.2. NM_001018658.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4673164.

Proteomic databases

MaxQBiO42650.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC10F6.10.1; SPAC10F6.10.1:pep; SPAC10F6.10.
GeneIDi2542923.
KEGGispo:SPAC10F6.10.

Organism-specific databases

EuPathDBiFungiDB:SPAC10F6.10.
PomBaseiSPAC10F6.10. rio1.

Phylogenomic databases

HOGENOMiHOG000166501.
InParanoidiO42650.
KOiK07178.
OMAiVEPDHPR.
OrthoDBiEOG7WDNCV.

Miscellaneous databases

NextBioi20803959.
PROiO42650.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017407. Ser/Thr_kinase_Rio1.
[Graphical view]
PANTHERiPTHR10593:SF23. PTHR10593:SF23. 1 hit.
PIRSFiPIRSF038147. Ser/Thr_PK_RIO1. 1 hit.
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00109. PROTEIN_KINASE_TYR. 1 hit.
PS01245. RIO1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRIO1_SCHPO
AccessioniPrimary (citable) accession number: O42650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 22, 2012
Last modified: January 20, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.