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Protein

CTP synthase

Gene

ura7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes CTP from UDP.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. CTP synthase (ura7)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from UDP, the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei403 – 4031For GATase activityPROSITE-ProRule annotation
Active sitei532 – 5321For GATase activityPROSITE-ProRule annotation
Active sitei534 – 5341For GATase activityPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.
UniPathwayiUPA00159; UER00277.

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthase (EC:6.3.4.2)
Alternative name(s):
CTP synthetase
UTP--ammonia ligase
Gene namesi
Name:ura7
ORF Names:SPAC10F6.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC10F6.03c.
PomBaseiSPAC10F6.03c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600CTP synthasePRO_0000138282Add
BLAST

Proteomic databases

MaxQBiO42644.

Interactioni

Protein-protein interaction databases

BioGridi279378. 2 interactions.
MINTiMINT-4673109.

Structurei

3D structure databases

ProteinModelPortaliO42644.
SMRiO42644. Positions 1-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini304 – 570267Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CTP synthase family.Curated
Contains 1 glutamine amidotransferase type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

HOGENOMiHOG000077514.
InParanoidiO42644.
KOiK01937.
OMAiDERTTHP.
OrthoDBiEOG7HMS8X.
PhylomeDBiO42644.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 1 hit.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYVLVSGGV ISGIGKGVIA SSTGLLLKTL GLKVTSIKID PYMNIDAGTM
60 70 80 90 100
SPLEHGEVFV LNDGGEVDLD LGNYERYLNV TLTHDNNITT GKVYSNVIQK
110 120 130 140 150
ERRGDYLGKT VQIVPHVTNE IQDWVERVAR IPVDQSGEEP DVCIVELGGT
160 170 180 190 200
VGDIESAAFV EAMRQFQFRV GHENFVSIHV SLVPVINGEQ KTKPTQQAIR
210 220 230 240 250
DLRSLGITPD LIACRCKQPL EKSVIDKISL FCHVGPEQVL AVHDVSSTYH
260 270 280 290 300
VPQLLEDKLL EYLKIRFALD KISVSRELAL AGENMWSSWK HLTQGYDHLF
310 320 330 340 350
KKVTIVLVGK YTHLQDSYIS VIKALEHSAM RCGRKLDLQW VEASHLEAST
360 370 380 390 400
NTSDPLSYHK AWHLVCSANG ILVPGGFGSR GVEGMIAAAK WARENNTPYL
410 420 430 440 450
GICLGMQVAV IEFARSVCGI EGAFSEEFDK ECENNVVVYM PEIDKDKLGG
460 470 480 490 500
TMRLGLRPTF FQPNSEWSKL RKLHKMVDEV LERHRHRYEI NPAFVSRLEQ
510 520 530 540 550
GGISFIGKDE RGERMEIIEK RDHPYFVGVQ YHPEYLSKPL KPSPPIFGLV
560 570 580 590 600
AASAGLLDEF IQSGEEVEWS NFSHFNAESA LADMNDSVEV TEEATVVTIS
Length:600
Mass (Da):66,867
Last modified:June 1, 1998 - v1
Checksum:i72D7EE95B678E4EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA15716.1.
PIRiT37497.
RefSeqiNP_593254.1. NM_001018651.2.

Genome annotation databases

EnsemblFungiiSPAC10F6.03c.1; SPAC10F6.03c.1:pep; SPAC10F6.03c.
GeneIDi2542937.
KEGGispo:SPAC10F6.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA15716.1.
PIRiT37497.
RefSeqiNP_593254.1. NM_001018651.2.

3D structure databases

ProteinModelPortaliO42644.
SMRiO42644. Positions 1-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279378. 2 interactions.
MINTiMINT-4673109.

Proteomic databases

MaxQBiO42644.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC10F6.03c.1; SPAC10F6.03c.1:pep; SPAC10F6.03c.
GeneIDi2542937.
KEGGispo:SPAC10F6.03c.

Organism-specific databases

EuPathDBiFungiDB:SPAC10F6.03c.
PomBaseiSPAC10F6.03c.

Phylogenomic databases

HOGENOMiHOG000077514.
InParanoidiO42644.
KOiK01937.
OMAiDERTTHP.
OrthoDBiEOG7HMS8X.
PhylomeDBiO42644.

Enzyme and pathway databases

UniPathwayiUPA00159; UER00277.
ReactomeiR-SPO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

PROiO42644.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 1 hit.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPYRG_SCHPO
AccessioniPrimary (citable) accession number: O42644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.