Reviewed, UniProtKB/Swiss-Prot O42632 (KPC1_COCHE)

Names and origin

Protein names

Recommended name:
    Protein kinase C-like
    EC=2.7.11.13

Gene names

Name:

PKC1

Organism

Cochliobolus heterostrophus (Drechslera maydis)

Taxonomic identifier

5016 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporaceae › Cochliobolus

Protein attributes

Sequence length	1174 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 phorbol-ester/DAG-type zinc fingers. Contains 1 protein kinase domain. Contains 2 REM (Hr1) repeats.

Ontologies

Keywords
Domain	Phorbol-ester binding Repeat Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW diacylglycerol binding Inferred from electronic annotation. Source: UniProtKB-KW protein kinase C activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1174	1174	Protein kinase C-like		PRO_0000055743
Regions
	Repeat	6 – 78	73	REM 1
	Repeat	161 – 236	76	REM 2
	Domain	849 – 1108	260	Protein kinase
	Domain	1109 – 1174	66	AGC-kinase C-terminal
	Zinc finger	458 – 506	49	Phorbol-ester/DAG-type 1
	Zinc finger	526 – 576	51	Phorbol-ester/DAG-type 2
	Nucleotide binding	855 – 863	9	ATP By similarity
	Compositional bias	704 – 709	6	Poly-Ala
	Compositional bias	785 – 792	8	Poly-Pro
Sites
	Active site	974	1	Proton acceptor By similarity
	Binding site	878	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	O42632-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 26A4ADD42849F37C	FASTA	1,174	130,506
	10 20 30 40 50 60 MANVEETVAN VQRKIDREKA LINAANAMRQ STNNPAVLSR LDGQIKDGRR NIDYFESKLR 70 80 90 100 110 120 DLDLQRTTSG VDNMSLQPGR SPTNPLTPPP KDNWDGYAQQ DQGGYGGPQS QYSQLSGGEA 130 140 150 160 170 180 LQPPRAPFAA PPPATANKRP NYSKLDLIKY DTPHLGPRIQ LMLTQLEFKL SVEKQYKDGI 190 200 210 220 230 240 EKMVRLYQME GDRKSKQDAE AKRIESNQKI QLLKHSLKRY EDLHVDIDGD GDDNDSLDIP 250 260 270 280 290 300 SQRKPLSGQL SLRIHAVADV DHAATGRFSR GPETFVNIKV EDTIKGRTKP TRNDRWTDEV 310 320 330 340 350 360 HDFSIDKANE IEITVYDKTG DHLLPIGMLW VRISDIAEEM RRKKLETELA NSGWVAADKM 370 380 390 400 410 420 GGHTGIQPDM QFQPPPGQSP AGGPGGGPTP AGVRPPGAPQ PQTGPIMIDD WFSLEPVGRI 430 440 450 460 470 480 HLTMSFIKNT GNKQPFDLGL GRKGAVRQRK EDVVEQYGHK FVQQQFYNVM RCALCAEFLK 490 500 510 520 530 540 YAAGMQCSDC NYTCHKKCYP KVVTKCITQS NAETDPDEAK LNHRIPHRFE NFSNMGANWC 550 560 570 580 590 600 CHCGYVLPLG RKQTKKCNEC GLTCHAHCVH FVPDFCGMSM EVANQILMEI KRTRRGQSSS 610 620 630 640 650 660 GPGMSQRTLR PQSAAKPLPP TQPQSPGQPG QESPTQSDRY SYGKEQMSPP PGPPRQPSYP 670 680 690 700 710 720 SSATSVDAAR ASYSTTGTAS TGAPTSPTSG SRPPSGPRTQ SSVAAAAAAM NKATQPGYGR 730 740 750 760 770 780 SNTDYSPQSG RSSGSGYPTE QRMSQQQAPQ PAAYDPSVYA NIPSYPPSHQ QPAPVPSYPT 790 800 810 820 830 840 KSSYPLPQPP PPQSPPQHPQ QPTPSQQKMP EQQALTQQPP SAVGEVPGKK VTPAANTQGT 850 860 870 880 890 900 GKRIGLDHFN FLAVLGKGNF GKVMLAETKT TKQLYAIKVL KKEFIIENDE VESTRSEKRV 910 920 930 940 950 960 FLIANKERHP FLLNLHACFQ TETRVYFVME YISGGDLMLH IQRGQFGTKR AQFYAAEVCL 970 980 990 1000 1010 1020 ALKYFHENGV IYRDLKLDNI MLTLDGHIKV ADYGLCKEEM WYGSTTSTFC GTPEFMAPEI 1030 1040 1050 1060 1070 1080 LLDKKYGRAV DWWAFGVLIY QMLLQQSPFR GEDEDEIYDA ILADEPLYPI HMPRDSVSIL 1090 1100 1110 1120 1130 1140 QKLLTREPEM RLGSGPTDAQ EIMSHAFFRN INWDDIYHKR VQPPFIPQIT SPTDTSNFDT 1150 1160 1170 EFTSVTPVLT PVQSVLSQAM QEEFRGFSYS ADFA

References

[1]	"PKC1, encoding a protein kinase C, and FAT1, encoding a fatty acid transporter protein, are neighbors in Cochliobolus heterostrophus." Oeser B. FEMS Microbiol. Lett. 165:273-280(1998) [PubMed: 9742699] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 48329 / C2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y15839 Genomic DNA. Translation: CAA75801.1.
PIR	T43051.
3D structure databases
HSSP	HSSP built from PDB template 1GZK based on UniProtKB P31751.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.13. 2898.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR000008. C2_Ca-dep. IPR000861. HR1-like_rho-bd. IPR011072. HR1_rho-bd. IPR015745. PKC. IPR017892. Pkinase_C. IPR002219. Prot_Kinase_C-like_PE/DAG_bd. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Gene3D	G3DSA:1.10.287.160. HR1_rho-bd. 1 hit.
PANTHER	PTHR22985:SF86. PKC. 1 hit.
Pfam	PF00130. C1_1. 2 hits. PF02185. HR1. 2 hits. PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00109. C1. 2 hits. SM00239. C2. 1 hit. SM00742. Hr1. 2 hits. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS00479. ZF_DAG_PE_1. 2 hits. PS50081. ZF_DAG_PE_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPC1_COCHE

Accession

Primary (citable) accession number: O42632

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	June 1, 1998
Last modified:	July 28, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)