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Protein

Neurogenin-1

Gene

neurog1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specification of dopaminergic progenitor cells. May be involved in maintaining rhombomere boundaries in the hindbrain.By similarity7 Publications

GO - Molecular functioni

GO - Biological processi

  • anterior lateral line nerve development Source: ZFIN
  • axonal fasciculation Source: ZFIN
  • axon regeneration Source: ZFIN
  • dorsal spinal cord development Source: ZFIN
  • forebrain neuron development Source: ZFIN
  • generation of neurons Source: UniProtKB
  • hindbrain morphogenesis Source: UniProtKB
  • negative regulation of neurogenesis Source: ZFIN
  • nervous system development Source: ZFIN
  • neuromast development Source: ZFIN
  • olfactory bulb development Source: ZFIN
  • olfactory placode development Source: ZFIN
  • peripheral nervous system development Source: UniProtKB
  • peripheral nervous system neuron development Source: ZFIN
  • positive regulation of neuron differentiation Source: UniProtKB
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • posterior lateral line nerve development Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-1
Short name:
NGN-1
Alternative name(s):
Neurogenic differentiation factor 3
Short name:
NeuroD3
Neurogenin-related protein 1
Gene namesi
Name:neurog1
Synonyms:neurod3, ngn1, ngr1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-990415-174. neurog1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273991 – 208Neurogenin-1Add BLAST208

Proteomic databases

PaxDbiO42606.

Expressioni

Tissue specificityi

Embryonic nervous system. Expressed transiently in neurogenic placodes prior to delamination and formation of cranial ganglia. Expressed early (6-somite stage) in Rohon-Beard spinal sensory neurons and later in neural crest-derived dorsal root ganglion neurons. At 24 hours post-fertilization (hpf), expressed in specific regions of the brain and spinal cord. In hindbrain, expressed in presumptive neuroblasts adjacent to the rhombomere boundaries. In basal forebrain, expressed in dopaminergic progenitor cells.7 Publications

Developmental stagei

First detected at the late gastrulation stage (9 hpf). Strongly expressed in distinct domains in the neural plate at the 3-somite stage. First expressed in the epiphysis at around 14 hpf.4 Publications

Gene expression databases

BgeeiENSDARG00000056130.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073024.

Structurei

3D structure databases

ProteinModelPortaliO42606.
SMRiO42606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 122bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG3898. Eukaryota.
ENOG4111U26. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiO42606.
KOiK09081.
OMAiYIWALAE.
OrthoDBiEOG091G0PNH.
PhylomeDBiO42606.
TreeFamiTF315153.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR036638. HLH_DNA-bd_sf.
IPR032653. Ngn1.
PANTHERiPTHR19290:SF130. PTHR19290:SF130. 2 hits.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

O42606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIVYSDMET SSCDYSFSHT DDEDSRSSLH PASPASSCGK PPASPAGLQQ
60 70 80 90 100
KKRRRGRARN ETTVHVVKKN RRLKANDRER NRMHNLNDAL DALRSVLPAF
110 120 130 140 150
PDDTKLTKIE TLRFAHNYIW ALSETIRIAD QKQGKSRDGP LLLPGLSCMA
160 170 180 190 200
DAPSPGSDSC SWPSGASSSS SSPSYCNSDP GSPAAMDDFG YLQTDVVYSY

RNFVPSIY
Length:208
Mass (Da):22,911
Last modified:January 1, 1998 - v1
Checksum:iCDE333AE483DC51A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017301 Genomic DNA. Translation: AAB70528.1.
AF024535 mRNA. Translation: AAB82271.1.
AF036149 mRNA. Translation: AAB88821.1.
U94588 mRNA. Translation: AAD09254.1.
BC056575 mRNA. Translation: AAH56575.1.
BC066427 mRNA. Translation: AAH66427.1.
RefSeqiNP_571116.1. NM_131041.1.
UniGeneiDr.75780.

Genome annotation databases

EnsembliENSDART00000078563; ENSDARP00000073024; ENSDARG00000056130.
GeneIDi30239.
KEGGidre:30239.

Similar proteinsi

Entry informationi

Entry nameiNGN1_DANRE
AccessioniPrimary (citable) accession number: O42606
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome