O42602 (CRFR1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Corticotropin-releasing factor receptor 1
Short name=CRF-R-1
Short name=CRF-R1
Short name=CRFR-1

Alternative name(s):
Corticotropin-releasing hormone receptor 1
Short name=CRH-R-1
Short name=CRH-R1

Gene names

Name:	crhr1
Synonyms:	crf1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for corticotropin releasing factor (CRH). Shows high-affinity binding for urotensin I. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase By similarity.
Subunit structure	Interacts (via N-terminal extracellular domain) with CRF and UCN By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 415	391	Corticotropin-releasing factor receptor 1		PRO_0000012819
Regions
	Topological domain	25 – 121	97	Extracellular Potential
	Transmembrane	122 – 142	21	Helical; Name=1; Potential
	Topological domain	143 – 151	9	Cytoplasmic Potential
	Transmembrane	152 – 171	20	Helical; Name=2; Potential
	Topological domain	172 – 189	18	Extracellular Potential
	Transmembrane	190 – 213	24	Helical; Name=3; Potential
	Topological domain	214 – 227	14	Cytoplasmic Potential
	Transmembrane	228 – 249	22	Helical; Name=4; Potential
	Topological domain	250 – 268	19	Extracellular Potential
	Transmembrane	269 – 291	23	Helical; Name=5; Potential
	Topological domain	292 – 314	23	Cytoplasmic Potential
	Transmembrane	315 – 334	20	Helical; Name=6; Potential
	Topological domain	335 – 349	15	Extracellular Potential
	Transmembrane	350 – 369	20	Helical; Name=7; Potential
	Topological domain	370 – 415	46	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Glycosylation	45	1	N-linked (GlcNAc...) Potential
	Glycosylation	78	1	N-linked (GlcNAc...) Potential
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Disulfide bond	30 ↔ 54		By similarity
	Disulfide bond	44 ↔ 87		By similarity
	Disulfide bond	68 ↔ 102		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O42602 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 74ED24C17907B74D	FASTA	415	47,786
	10 20 30 40 50 60 MLLAKTPCLL LVQVIAAGIS FALTSLQDQC ETLQHNSNFT GLACNASIDM IGTCWPSTAA 70 80 90 100 110 120 GQMVARPCPE YFHGVQYNTT GNVYRECHLN GSWAGRGDYA QCQEILKQEK KTKVHYHIAI 130 140 150 160 170 180 VINFLGHSIS LCALLVAFIL FLRLRSIRCL RNIIHWNLIT AFILRNVTWF VMQLTLSHEA 190 200 210 220 230 240 HDSNVVWCRL VTIAHNYFYV TNFFWMFGEG CYLHTAIVLT YSTDKLRKWM FICIGWCIPF 250 260 270 280 290 300 PIIVAWAIGK LYYDNEKCWF GKKAGVYTDF IYQGPVILVL LINFIFLFNI VRILMTKLRA 310 320 330 340 350 360 STTSETIQYR KAVKATLVLL PLLGITYMLF FVTPGEDEIS RIVFIYFNSF LQSFQGFFVS 370 380 390 400 410 VFYCFLNSEV RSAVRKRWHR WQDKHSIRAR VARAMSIPTS PTRISFHSIK QSSAI

References

[1]

"Identification of two corticotropin-releasing factor receptors from Xenopus laevis with high ligand selectivity: unusual pharmacology of the type 1 receptor." Dautzenberg F.M., Dietrich K., Palchaudhuri M.R., Spiess J. J. Neurochem. 69:1640-1649(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y14036 mRNA. Translation: CAA74363.1.
RefSeq	NP_001079049.1. NM_001085580.1.
UniGene	Xl.52.
3D structure databases
ProteinModelPortal	O42602.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	373580.
KEGG	xla:373580.
Organism-specific databases
CTD	373580.
Xenbase	XB-GENE-968270. crhr1.2.
Phylogenomic databases
HOVERGEN	HBG106921.
KO	K04578.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR003052. GPCR_2_CRF1_rcpt. IPR003051. GPCR_2_CRF_rcpt. IPR001879. GPCR_2_extracellular_dom. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF02793. HRM. 1 hit. [Graphical view]
PRINTS	PR01279. CRFRECEPTOR. PR01280. CRFRECEPTOR1. PR00249. GPCRSECRETIN.
SMART	SM00008. HormR. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. 1 hit. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CRFR1_XENLA

Accession

Primary (citable) accession number: O42602

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program