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Protein
Submitted name:

Integrin alphaV subunit

Gene

itgav

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotationImported, ReceptorUniRule annotationSAAS annotation

Keywords - Biological processi

Cell adhesionUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin alphaV subunitImported
Gene namesi
Name:itgavImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865825. itgav.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei979 – 100123HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919UniRule annotationAdd
BLAST
Chaini20 – 10331014UniRule annotationPRO_5001425684Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO42598.
SMRiO42598. Positions 20-968, 973-1011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini456 – 899444Integrin_alpha2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation
Contains FG-GAP repeats.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG006186.
KOiK06487.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALVLLLHF LCIRQLCYCF NLDVDNPFVK SGAEGSYFGF AVDFLSTGSS
60 70 80 90 100
GSYLLVGAPK ANTSQPGIIE GGDVIKCDWK KSDCQSVVFD PNGNRNYAVN
110 120 130 140 150
ESIEFKSHQW FGASVRAKHN KIMACAPLYH WRTEVKQERE PVGTCYLNDG
160 170 180 190 200
TTVVEYAPCR SSAKTDAQEH GFCQGGFSIE FTEADRVLLG GPGSFYWQGQ
210 220 230 240 250
LISDQVDEIV KKYTPGKYSI TYENQLATRP ASPSHDDSYL GYSVTVGDFN
260 270 280 290 300
GDNIEDFVSG VPRAAKTLGM VSIYDGKSMV SLYNFTGEQM AAYFGYSVAT
310 320 330 340 350
SDINGDGLVD LFIGTPLFMD RGSDGKLQEL GQVSVYLQHS TNGPQPLLKL
360 370 380 390 400
TGFEVFARFG SCIGPLGDVD GDGFNDLAIA APYGGVNKKG LVYIYNGRPT
410 420 430 440 450
GLSVVPSQIL EGQWASQHMP SSFGYSLKGA TDVDENGYPD LLVGAFGADK
460 470 480 490 500
AILYRARPVI TVTSLLEVNP TILNPESKTC ILPSGTKVSC FHVKFCLKAV
510 520 530 540 550
GKGRVPQDLP FRVDLLLDKH KQKGAIRRAL FLHTRLSSHS KNMTIQNGGS
560 570 580 590 600
MRCEELQAFL RDDSEFRDKL TPITIFMEFQ MDYKSTADSS GLLPILNQFT
610 620 630 640 650
PANITKQAHI LLDCGEDNIC KPSLKLSVES EQKKIFIGDD SPLTLIVNAQ
660 670 680 690 700
NQGEGAYEAE LVVQMPPEAD FIGVIRNNET FSRLSCAFKT ENQTNLVVCD
710 720 730 740 750
LGNPMKAGTQ IKAALLFSVH QLTEMDNSVK FDLQIRSSNQ YENSSTVESI
760 770 780 790 800
EIALAVLAAV EVRGVSTPNE VFLPIANWEP KVNPVTEEDI GPLVQHIFEL
810 820 830 840 850
RNNGPSGFSK AILNLQWPYR YNNDTLLYIV KYETDGPMDC TSDVEINPLN
860 870 880 890 900
VKISTSQSDE KNESRVPDNR QRNRRDLTAM DGPLQTLGCG QAECLKIECH
910 920 930 940 950
VGRLDKGKSA ILYVRSRLWT QTFLQNGNQN HSYSLKSSAS FSVLEFPYKN
960 970 980 990 1000
IHIPDIQNST VVTTNILWVN QAASLPVPIW VIILAVLSGL LLLSLMVFIM
1010 1020 1030
YKLGFFKRVR PPQEETEREQ LQPQENGEGI TDT
Length:1,033
Mass (Da):114,025
Last modified:January 1, 1998 - v1
Checksum:i35F73B0765C06BD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92006 mRNA. Translation: AAB62090.1.
RefSeqiNP_001081685.1. NM_001088216.1.
UniGeneiXl.185.

Genome annotation databases

GeneIDi397997.
KEGGixla:397997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92006 mRNA. Translation: AAB62090.1.
RefSeqiNP_001081685.1. NM_001088216.1.
UniGeneiXl.185.

3D structure databases

ProteinModelPortaliO42598.
SMRiO42598. Positions 20-968, 973-1011.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397997.
KEGGixla:397997.

Organism-specific databases

CTDi397997.
XenbaseiXB-GENE-865825. itgav.

Phylogenomic databases

HOVERGENiHBG006186.
KOiK06487.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO42598_XENLA
AccessioniPrimary (citable) accession number: O42598
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.