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O42563 (CP3AR_ONCMY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A27

EC=1.14.14.1
Alternative name(s):
CYPIIIA27
Gene names
Name:cyp3a27
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Cytochrome P450 3A27
PRO_0000051806

Sites

Metal binding4471Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O42563 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9B93AA12E617D0DF

FASTA51859,211
        10         20         30         40         50         60 
MMSFLPYFSA ETWTLLALLI TLIVVYGYWP YGVFTKMGIP GPKPLPYFGT MLEYKKGFTN 

        70         80         90        100        110        120 
FDTECFQKYG RIWGIYDGRQ PVLCIMDKSM IKTVLIKECY NIFTNRRNFH LNGELFDALS 

       130        140        150        160        170        180 
VAEDDTWRRI RSVLSPSFTS GRLKEMFGIM KQHSSTLLSG MKKQADKDQT IEVKEFFGPY 

       190        200        210        220        230        240 
SMDVVTSTAF SVDIDSLNNP SDPFVSNVKK MLKFDLFNPL FLLVALFPFT GPILEKMKFS 

       250        260        270        280        290        300 
FFPTAVTDFF YASLAKIKSG RDTGNSTNRV DFLQLMIDSQ KGSDTKTGEE QTKGLTDHEI 

       310        320        330        340        350        360 
LSQAMIFIFA GYETSSSTMS FLAYNLATNH HVMTKLQEEI DTVFPNKAPI QYEALMQMDY 

       370        380        390        400        410        420 
LDCVLNESLR LYPIAPRLER VAKKTVEING IVIPKDCIVL VPTWTLHRDP EIWSDPEEFK 

       430        440        450        460        470        480 
PERFSKENKE SIDPYTYMPF GAGPRNCIGM RFALIMIKLA MVEILQSFTF SVCDETEIPL 

       490        500        510 
EMDNQGLLMP KRPIKLRLEA RRNTPSNTTA TTLKSPTT 

« Hide

References

[1]"Cloning, sequencing, and tissue expression of CYP3A27, a new member of the CYP3A subfamily from embryonic and adult rainbow trout livers."
Lee S.-J., Wang-Buhler J.-L., Cok I., Yu T.S., Yang Y.H., Miranda C.L., Lech J., Buhler D.R.
Arch. Biochem. Biophys. 360:53-61(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Shasta.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U96077 mRNA. Translation: AAB82422.1.

3D structure databases

ProteinModelPortalO42563.
SMRO42563. Positions 31-504.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG108567.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3AR_ONCMY
AccessionPrimary (citable) accession number: O42563
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families