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O42563

- CP3AR_ONCMY

UniProt

O42563 - CP3AR_ONCMY

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Protein

Cytochrome P450 3A27

Gene

cyp3a27

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A27 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA27
Gene namesi
Name:cyp3a27
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Cytochrome P450 3A27PRO_0000051806Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliO42563.
SMRiO42563. Positions 31-504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG108567.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42563 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMSFLPYFSA ETWTLLALLI TLIVVYGYWP YGVFTKMGIP GPKPLPYFGT
60 70 80 90 100
MLEYKKGFTN FDTECFQKYG RIWGIYDGRQ PVLCIMDKSM IKTVLIKECY
110 120 130 140 150
NIFTNRRNFH LNGELFDALS VAEDDTWRRI RSVLSPSFTS GRLKEMFGIM
160 170 180 190 200
KQHSSTLLSG MKKQADKDQT IEVKEFFGPY SMDVVTSTAF SVDIDSLNNP
210 220 230 240 250
SDPFVSNVKK MLKFDLFNPL FLLVALFPFT GPILEKMKFS FFPTAVTDFF
260 270 280 290 300
YASLAKIKSG RDTGNSTNRV DFLQLMIDSQ KGSDTKTGEE QTKGLTDHEI
310 320 330 340 350
LSQAMIFIFA GYETSSSTMS FLAYNLATNH HVMTKLQEEI DTVFPNKAPI
360 370 380 390 400
QYEALMQMDY LDCVLNESLR LYPIAPRLER VAKKTVEING IVIPKDCIVL
410 420 430 440 450
VPTWTLHRDP EIWSDPEEFK PERFSKENKE SIDPYTYMPF GAGPRNCIGM
460 470 480 490 500
RFALIMIKLA MVEILQSFTF SVCDETEIPL EMDNQGLLMP KRPIKLRLEA
510
RRNTPSNTTA TTLKSPTT
Length:518
Mass (Da):59,211
Last modified:January 1, 1998 - v1
Checksum:i9B93AA12E617D0DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96077 mRNA. Translation: AAB82422.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96077 mRNA. Translation: AAB82422.1 .

3D structure databases

ProteinModelPortali O42563.
SMRi O42563. Positions 31-504.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG108567.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, sequencing, and tissue expression of CYP3A27, a new member of the CYP3A subfamily from embryonic and adult rainbow trout livers."
    Lee S.-J., Wang-Buhler J.-L., Cok I., Yu T.S., Yang Y.H., Miranda C.L., Lech J., Buhler D.R.
    Arch. Biochem. Biophys. 360:53-61(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Shasta.
    Tissue: Liver.

Entry informationi

Entry nameiCP3AR_ONCMY
AccessioniPrimary (citable) accession number: O42563
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3