Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O42563

- CP3AR_ONCMY

UniProt

O42563 - CP3AR_ONCMY

Protein

Cytochrome P450 3A27

Gene

cyp3a27

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A27 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA27
    Gene namesi
    Name:cyp3a27
    OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
    Taxonomic identifieri8022 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518Cytochrome P450 3A27PRO_0000051806Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Structurei

    3D structure databases

    ProteinModelPortaliO42563.
    SMRiO42563. Positions 31-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG108567.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42563-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMSFLPYFSA ETWTLLALLI TLIVVYGYWP YGVFTKMGIP GPKPLPYFGT    50
    MLEYKKGFTN FDTECFQKYG RIWGIYDGRQ PVLCIMDKSM IKTVLIKECY 100
    NIFTNRRNFH LNGELFDALS VAEDDTWRRI RSVLSPSFTS GRLKEMFGIM 150
    KQHSSTLLSG MKKQADKDQT IEVKEFFGPY SMDVVTSTAF SVDIDSLNNP 200
    SDPFVSNVKK MLKFDLFNPL FLLVALFPFT GPILEKMKFS FFPTAVTDFF 250
    YASLAKIKSG RDTGNSTNRV DFLQLMIDSQ KGSDTKTGEE QTKGLTDHEI 300
    LSQAMIFIFA GYETSSSTMS FLAYNLATNH HVMTKLQEEI DTVFPNKAPI 350
    QYEALMQMDY LDCVLNESLR LYPIAPRLER VAKKTVEING IVIPKDCIVL 400
    VPTWTLHRDP EIWSDPEEFK PERFSKENKE SIDPYTYMPF GAGPRNCIGM 450
    RFALIMIKLA MVEILQSFTF SVCDETEIPL EMDNQGLLMP KRPIKLRLEA 500
    RRNTPSNTTA TTLKSPTT 518
    Length:518
    Mass (Da):59,211
    Last modified:January 1, 1998 - v1
    Checksum:i9B93AA12E617D0DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U96077 mRNA. Translation: AAB82422.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U96077 mRNA. Translation: AAB82422.1 .

    3D structure databases

    ProteinModelPortali O42563.
    SMRi O42563. Positions 31-504.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG108567.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing, and tissue expression of CYP3A27, a new member of the CYP3A subfamily from embryonic and adult rainbow trout livers."
      Lee S.-J., Wang-Buhler J.-L., Cok I., Yu T.S., Yang Y.H., Miranda C.L., Lech J., Buhler D.R.
      Arch. Biochem. Biophys. 360:53-61(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Shasta.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP3AR_ONCMY
    AccessioniPrimary (citable) accession number: O42563
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3