ID   HXC6A_TAKRU             Reviewed;         236 AA.
AC   O42504;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   24-JAN-2024, entry version 124.
DE   RecName: Full=Homeobox protein Hox-C6a;
DE   AltName: Full=FrHOXC-6;
GN   Name=hoxc6a; Synonyms=hoxc6;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9140399; DOI=10.1038/ng0597-79;
RA   Aparicio S.J., Hawker K., Cottage A., Mikawa Y., Zuo L., Venkatesh B.,
RA   Chen E., Krumlauf R., Brenner S.;
RT   "Organization of the Fugu rubripes Hox clusters: evidence for continuing
RT   evolution of vertebrate Hox complexes.";
RL   Nat. Genet. 16:79-83(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; U92572; AAB68682.1; -; Genomic_DNA.
DR   EMBL; DQ481667; ABF22446.1; -; Genomic_DNA.
DR   RefSeq; XP_003963113.1; XM_003963064.2.
DR   AlphaFoldDB; O42504; -.
DR   SMR; O42504; -.
DR   STRING; 31033.ENSTRUP00000008754; -.
DR   Ensembl; ENSTRUT00000008805.3; ENSTRUP00000008754.3; ENSTRUG00000022036.2.
DR   GeneID; 101078451; -.
DR   KEGG; tru:101078451; -.
DR   CTD; 30346; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000159254; -.
DR   InParanoid; O42504; -.
DR   OMA; RIYTPFY; -.
DR   OrthoDB; 728401at2759; -.
DR   Proteomes; UP000005226; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR   PANTHER; PTHR45659:SF1; HOMEOBOX PROTEIN HOX-C6; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..236
FT                   /note="Homeobox protein Hox-C6a"
FT                   /id="PRO_0000265988"
FT   DNA_BIND        140..199
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          198..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           121..126
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        213..236
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   236 AA;  27181 MW;  AC203E8AF4F09619 CRC64;
     MNSYFANPSL SCHLSGGQDV LPNVPLNSTT YDTVRHFSSY GAAVTQNRIY APFYSPQDNV
     VFGSGRAQYD YGSNVFLQDK DVLPSCRQTN MGLSTQSHIA QEYSLDQGRT GTQEQKSNIP
     IYPWMQRMNS HSGVGYGTDR RRGRQIYSRY QTLELEKEFH FNRYLTRRRR IEIANALCLT
     ERQIKIWFQN RRMKWKKESN LTSTVTGSEQ TGGSQEERED RGGATEEGKD EDKKKE
//