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O42503

- HXC8A_TAKRU

UniProt

O42503 - HXC8A_TAKRU

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Protein

Homeobox protein Hox-C8a

Gene

hoxc8a

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi225 – 28460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C8a
Alternative name(s):
FrHOXC-8
Gene namesi
Name:hoxc8a
Synonyms:hoxc8
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Homeobox protein Hox-C8aPRO_0000265989Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000008754.

Structurei

3D structure databases

ProteinModelPortaliO42503.
SMRiO42503. Positions 225-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi138 – 1436Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

InParanoidiO42503.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42503-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSYFVNPLF SKYKGGESLE PTYYDCRFPQ SVARSHTLVY GPGGAAPGFQ
60 70 80 90 100
HPSHHVQDFF HHGTTGISNP GYQQNPCALA CHGDATKFYG YEALPRQTLY
110 120 130 140 150
GTQQDASLAQ YPDCKSSSSS NPGEGQGHLN QNSSPSLMFP WMRPHGQNNT
160 170 180 190 200
VISYIFSPMF LCVRAYVRVC VCMSVFVCVL KCCLSARVSL TYKMKLVREH
210 220 230 240 250
DGAHRTCTAG CCCSAAHVHT GLDGRRNGRQ TYSRYQTLEL EKEFLFNPYL
260 270 280 290 300
TRKRRIEVSH ALSLTERQVK IWFQNRRMKW KKENNKTSFR VRGERLKPRK
310 320 330 340 350
RATRTVKGKR RKRKKRKRKR RPRSDFMVLF MVIWLKGRKK EWPHKQMKSH
360 370 380 390
KESESVNFMT ILSFFFCREE NRNPTNVAVI NRQKKSSTFI LT
Length:392
Mass (Da):45,427
Last modified:January 1, 1998 - v1
Checksum:iA45B1D64485D93E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92572 Genomic DNA. Translation: AAB68681.1.
DQ481667 Genomic DNA. Translation: ABF22445.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92572 Genomic DNA. Translation: AAB68681.1 .
DQ481667 Genomic DNA. Translation: ABF22445.1 .

3D structure databases

ProteinModelPortali O42503.
SMRi O42503. Positions 225-284.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 31033.ENSTRUP00000008754.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

InParanoidi O42503.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Organization of the Fugu rubripes Hox clusters: evidence for continuing evolution of vertebrate Hox complexes."
    Aparicio S.J., Hawker K., Cottage A., Mikawa Y., Zuo L., Venkatesh B., Chen E., Krumlauf R., Brenner S.
    Nat. Genet. 16:79-83(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
    Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
    Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHXC8A_TAKRU
AccessioniPrimary (citable) accession number: O42503
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3