O42503 (HXC8A_TAKRU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-C8a

Alternative name(s):
FrHOXC-8

Gene names

Name:	hoxc8a
Synonyms:	hoxc8

Organism

Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) [Reference proteome]

Taxonomic identifier

31033 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Acanthopterygii › Euacanthopterygii › Percomorpha › Tetraodontiformes › Tetraodontoidei › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Homeobox protein Hox-C8a		PRO_0000265989
Regions
	DNA binding	225 – 284	60	Homeobox
	Motif	138 – 143	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	O42503 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: A45B1D64485D93E4	FASTA	392	45,427
	10 20 30 40 50 60 MSSYFVNPLF SKYKGGESLE PTYYDCRFPQ SVARSHTLVY GPGGAAPGFQ HPSHHVQDFF 70 80 90 100 110 120 HHGTTGISNP GYQQNPCALA CHGDATKFYG YEALPRQTLY GTQQDASLAQ YPDCKSSSSS 130 140 150 160 170 180 NPGEGQGHLN QNSSPSLMFP WMRPHGQNNT VISYIFSPMF LCVRAYVRVC VCMSVFVCVL 190 200 210 220 230 240 KCCLSARVSL TYKMKLVREH DGAHRTCTAG CCCSAAHVHT GLDGRRNGRQ TYSRYQTLEL 250 260 270 280 290 300 EKEFLFNPYL TRKRRIEVSH ALSLTERQVK IWFQNRRMKW KKENNKTSFR VRGERLKPRK 310 320 330 340 350 360 RATRTVKGKR RKRKKRKRKR RPRSDFMVLF MVIWLKGRKK EWPHKQMKSH KESESVNFMT 370 380 390 ILSFFFCREE NRNPTNVAVI NRQKKSSTFI LT

References

[1]	"Organization of the Fugu rubripes Hox clusters: evidence for continuing evolution of vertebrate Hox complexes." Aparicio S.J., Hawker K., Cottage A., Mikawa Y., Zuo L., Venkatesh B., Chen E., Krumlauf R., Brenner S. Nat. Genet. 16:79-83(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters." Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B. Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U92572 Genomic DNA. Translation: AAB68681.1. DQ481667 Genomic DNA. Translation: ABF22445.1.
3D structure databases
HSSP	HSSP built from PDB template 9ANT based on UniProtKB P02833.
ProteinModelPortal	O42503.
SMR	O42503. Positions 225-284.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXC8A_TAKRU

Accession

Primary (citable) accession number: O42503

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program