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O42503 (HXC8A_TAKRU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-C8a
Alternative name(s):
FrHOXC-8
Gene names
Name:hoxc8a
Synonyms:hoxc8
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes) [Reference proteome]
Taxonomic identifier31033 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Homeobox protein Hox-C8a
PRO_0000265989

Regions

DNA binding225 – 28460Homeobox
Motif138 – 1436Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
O42503 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: A45B1D64485D93E4

FASTA39245,427
        10         20         30         40         50         60 
MSSYFVNPLF SKYKGGESLE PTYYDCRFPQ SVARSHTLVY GPGGAAPGFQ HPSHHVQDFF 

        70         80         90        100        110        120 
HHGTTGISNP GYQQNPCALA CHGDATKFYG YEALPRQTLY GTQQDASLAQ YPDCKSSSSS 

       130        140        150        160        170        180 
NPGEGQGHLN QNSSPSLMFP WMRPHGQNNT VISYIFSPMF LCVRAYVRVC VCMSVFVCVL 

       190        200        210        220        230        240 
KCCLSARVSL TYKMKLVREH DGAHRTCTAG CCCSAAHVHT GLDGRRNGRQ TYSRYQTLEL 

       250        260        270        280        290        300 
EKEFLFNPYL TRKRRIEVSH ALSLTERQVK IWFQNRRMKW KKENNKTSFR VRGERLKPRK 

       310        320        330        340        350        360 
RATRTVKGKR RKRKKRKRKR RPRSDFMVLF MVIWLKGRKK EWPHKQMKSH KESESVNFMT 

       370        380        390 
ILSFFFCREE NRNPTNVAVI NRQKKSSTFI LT 

« Hide

References

[1]"Organization of the Fugu rubripes Hox clusters: evidence for continuing evolution of vertebrate Hox complexes."
Aparicio S.J., Hawker K., Cottage A., Mikawa Y., Zuo L., Venkatesh B., Chen E., Krumlauf R., Brenner S.
Nat. Genet. 16:79-83(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U92572 Genomic DNA. Translation: AAB68681.1.
DQ481667 Genomic DNA. Translation: ABF22445.1.

3D structure databases

ProteinModelPortalO42503.
SMRO42503. Positions 225-284.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING31033.ENSTRUP00000008754.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXC8A_TAKRU
AccessionPrimary (citable) accession number: O42503
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries