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Protein

Homeobox protein Hox-C9a

Gene

hoxc9a

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi193 – 25260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C9a
Alternative name(s):
FrHOXC-9
Gene namesi
Name:hoxc9a
Synonyms:hoxc9
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Homeobox protein Hox-C9aPRO_0000200188Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO42502.
SMRiO42502. Positions 181-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00760000118945.
InParanoidiO42502.
KOiK09294.
OMAiRRAECGP.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
IPR017112. HXA9/HXB9/HXC9.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTGPITNY YVDSLINHEN EDVLAAARFS AQGSHPAGPR TTSLVPECAD
60 70 80 90 100
FPSCSFAPKA PVFSTSWAPM HTQPSVGYHP YSHQPHLATD SRYMRSWLEP
110 120 130 140 150
ISGAVPFHGY PGNGRHYGLK PDAFQEHRAG DCLGSTGRTY ADYLYCTADI
160 170 180 190 200
RDKTHQNIPS PEPELVASGK HKDEKPELDP NNPVANWIHA RSTRKKRCPY
210 220 230 240 250
TKYQTLELEK EFLFNMYLTR DRRFEVARVL NLTERQVKIW FQNRRMKMKK
260
MNKEKNDSKE Q
Length:261
Mass (Da):29,920
Last modified:August 14, 2001 - v2
Checksum:i4710CCF7C55F346D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92572 Genomic DNA. Translation: AAB68680.2.
DQ481667 Genomic DNA. Translation: ABF22444.1.
RefSeqiXP_003963115.1. XM_003963066.2.

Genome annotation databases

EnsembliENSTRUT00000008809; ENSTRUP00000008758; ENSTRUG00000003727.
GeneIDi101078902.
KEGGitru:101078902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92572 Genomic DNA. Translation: AAB68680.2.
DQ481667 Genomic DNA. Translation: ABF22444.1.
RefSeqiXP_003963115.1. XM_003963066.2.

3D structure databases

ProteinModelPortaliO42502.
SMRiO42502. Positions 181-255.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTRUT00000008809; ENSTRUP00000008758; ENSTRUG00000003727.
GeneIDi101078902.
KEGGitru:101078902.

Organism-specific databases

CTDi3225.

Phylogenomic databases

GeneTreeiENSGT00760000118945.
InParanoidiO42502.
KOiK09294.
OMAiRRAECGP.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
IPR017112. HXA9/HXB9/HXC9.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Organization of the Fugu rubripes Hox clusters: evidence for continuing evolution of vertebrate Hox complexes."
    Aparicio S.J., Hawker K., Cottage A., Mikawa Y., Zuo L., Venkatesh B., Chen E., Krumlauf R., Brenner S.
    Nat. Genet. 16:79-83(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Aparicio S.J.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters."
    Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.
    Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHXC9A_TAKRU
AccessioniPrimary (citable) accession number: O42502
Secondary accession number(s): Q1KKV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 14, 2001
Last modified: May 11, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.